hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03723
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | UniProt NCBI |
| ENO3 | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | UniProt NCBI |
| IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01230 | 0.00110943942397 | 0.666666666667 | ENO3 IDH2 | Biosynthesis of amino acids |
| KEGG:01200 | 0.00287006078872 | 0.666666666667 | ENO3 IDH2 | Carbon metabolism |
| KEGG:01100 | 0.0105851300972 | 1.0 | ENO3 IDH2 MTHFD1 | Metabolic pathways |
| CORUM:6948 | 0.0249904952816 | 0.333333333333 | IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial |
| HP:0025142 | 0.0417364037536 | 1.0 | ENO3 IDH2 MTHFD1 | Constitutional symptom |
| WP:WP4519 | 0.0499785733994 | 0.333333333333 | IDH2 | Cerebral Organic Acidurias, including diseases |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MTHFD1 | IDH2 | 0.991 | 0.91 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IDH2 | ENO3 | 0.572 | 0.655 | fraction treiber_WMM |
| MTHFD1 | ENO3 | 0.096 | 0.358 | youn_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_03723 has an average edge precision of 0.641 which is ranked 1714 out of all 6965 complexes.
Related Complexes