hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03738
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FBXW4 | F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4) | UniProt NCBI |
| CCT4 | T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding) | UniProt NCBI |
| CYP27A1 | Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) | UniProt NCBI |
| CCT6B | T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-390471 | 1.13724154433e-05 | 0.75 | CCT4 FBXW4 CCT6B | Association of TriC/CCT with target proteins during biosynthesis |
| REAC:R-HSA-390466 | 0.000157957097998 | 0.75 | CCT4 FBXW4 CCT6B | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 0.000192050220564 | 0.75 | CCT4 FBXW4 CCT6B | Protein folding |
| REAC:R-HSA-390450 | 0.000452175281072 | 0.5 | CCT4 CCT6B | Folding of actin by CCT/TriC |
| REAC:R-HSA-389960 | 0.00276986547413 | 0.5 | CCT4 CCT6B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-389957 | 0.00352159938331 | 0.5 | CCT4 CCT6B | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-389958 | 0.00466369436644 | 0.5 | CCT4 CCT6B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-6814122 | 0.00742649434549 | 0.5 | CCT4 CCT6B | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-5578996 | 0.0499190562503 | 0.25 | CYP27A1 | Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCT6B | CCT4 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM |
| CCT4 | FBXW4 | 0.117 | 0.389 | bioplex (FBXW4) bioplex_WMM |
| CCT6B | CYP27A1 | 0.05 | 0.298 | Guru fraction |
| CCT6B | FBXW4 | 0.013 | 0.151 | bioplex (FBXW4) bioplex_WMM |
| CYP27A1 | CCT4 | 0.007 | 0.005 | WMM_only treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_03738 has an average edge precision of 0.358 which is ranked 3783 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FBXW4 | HuMAP2_03738 HuMAP2_04444 HuMAP2_05380 HuMAP2_06732 |
| CCT4 | HuMAP2_02480 HuMAP2_03738 HuMAP2_04444 HuMAP2_05380 HuMAP2_06101 HuMAP2_06732 |
| CYP27A1 | HuMAP2_02430 HuMAP2_03738 HuMAP2_04444 HuMAP2_05380 |
| CCT6B | HuMAP2_02430 HuMAP2_02480 HuMAP2_03738 HuMAP2_04444 HuMAP2_05380 HuMAP2_06101 |