hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03750
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDCL | Phosducin-like protein (PHLP) | UniProt NCBI |
| GNB5 | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | UniProt NCBI |
| RGS6 | Regulator of G-protein signaling 6 (RGS6) (S914) | UniProt NCBI |
| RGS9 | Regulator of G-protein signaling 9 (RGS9) | UniProt NCBI |
| GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6814122 | 1.41214366606e-11 | 1.0 | GNB5 GNB2 PDCL RGS9 RGS6 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-390466 | 1.07793184337e-09 | 1.0 | GNB5 GNB2 PDCL RGS9 RGS6 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 1.49917343291e-09 | 1.0 | GNB5 GNB2 PDCL RGS9 RGS6 | Protein folding |
| WP:WP536 | 7.37592908394e-07 | 0.8 | GNB5 GNB2 RGS6 RGS9 | Calcium Regulation in the Cardiac Cell |
| WP:WP289 | 1.05142095686e-06 | 0.8 | GNB5 GNB2 RGS6 RGS9 | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-418594 | 6.804840425e-05 | 0.8 | GNB5 GNB2 RGS6 RGS9 | G alpha (i) signalling events |
| REAC:R-HSA-388396 | 0.00122449193088 | 0.8 | GNB5 GNB2 RGS6 RGS9 | GPCR downstream signalling |
| REAC:R-HSA-8964315 | 0.00161668141155 | 0.4 | GNB5 GNB2 | G beta:gamma signalling through BTK |
| REAC:R-HSA-372790 | 0.0016972853423 | 0.8 | GNB5 GNB2 RGS6 RGS9 | Signaling by GPCR |
| REAC:R-HSA-392851 | 0.00183199274719 | 0.4 | GNB5 GNB2 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-418217 | 0.00206071490935 | 0.4 | GNB5 GNB2 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-8964616 | 0.00206071490935 | 0.4 | GNB5 GNB2 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-500657 | 0.00230284247734 | 0.4 | GNB5 GNB2 | Presynaptic function of Kainate receptors |
| REAC:R-HSA-392170 | 0.00255837003151 | 0.4 | GNB5 GNB2 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-392451 | 0.00282729215335 | 0.4 | GNB5 GNB2 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-420092 | 0.00282729215335 | 0.4 | GNB5 GNB2 | Glucagon-type ligand receptors |
| REAC:R-HSA-428930 | 0.00282729215335 | 0.4 | GNB5 GNB2 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-418592 | 0.0031096034254 | 0.4 | GNB5 GNB2 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | GNB5 GNB2 PDCL RGS9 RGS6 | Metabolism of proteins |
| REAC:R-HSA-400042 | 0.00437263170532 | 0.4 | GNB5 GNB2 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-202040 | 0.00437263170532 | 0.4 | GNB5 GNB2 | G-protein activation |
| REAC:R-HSA-451326 | 0.00472180750517 | 0.4 | GNB5 GNB2 | Activation of kainate receptors upon glutamate binding |
| GO:0006457 | 0.00477625207691 | 0.8 | GNB5 GNB2 PDCL RGS9 | protein folding |
| REAC:R-HSA-397795 | 0.00508433997358 | 0.4 | GNB5 GNB2 | G-protein beta:gamma signalling |
| REAC:R-HSA-456926 | 0.00508433997358 | 0.4 | GNB5 GNB2 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-392518 | 0.00546022370076 | 0.4 | GNB5 GNB2 | Signal amplification |
| REAC:R-HSA-381676 | 0.00799559968784 | 0.4 | GNB5 GNB2 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-432040 | 0.00894729002053 | 0.4 | GNB5 GNB2 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 0.00995219083388 | 0.4 | GNB5 GNB2 | Aquaporin-mediated transport |
| WP:WP2355 | 0.0115135837289 | 0.4 | GNB5 GNB2 | Corticotropin-releasing hormone signaling pathway |
| WP:WP35 | 0.0123508080289 | 0.4 | GNB5 GNB2 | G Protein Signaling Pathways |
| REAC:R-HSA-418597 | 0.0126969553517 | 0.4 | GNB5 GNB2 | G alpha (z) signalling events |
| KEGG:04727 | 0.0130921728933 | 0.4 | GNB5 GNB2 | GABAergic synapse |
| KEGG:05032 | 0.0137641082753 | 0.4 | GNB5 GNB2 | Morphine addiction |
| KEGG:04713 | 0.0162467151192 | 0.4 | GNB5 GNB2 | Circadian entrainment |
| GO:0003924 | 0.0179259894308 | 0.8 | GNB5 GNB2 RGS6 RGS9 | GTPase activity |
| REAC:R-HSA-4086398 | 0.0184727645209 | 0.4 | GNB5 GNB2 | Ca2+ pathway |
| KEGG:04726 | 0.0189323955438 | 0.4 | GNB5 GNB2 | Serotonergic synapse |
| KEGG:04725 | 0.0193326076279 | 0.4 | GNB5 GNB2 | Cholinergic synapse |
| KEGG:04724 | 0.020974746694 | 0.4 | GNB5 GNB2 | Glutamatergic synapse |
| WP:WP3929 | 0.0250517914711 | 0.4 | GNB5 GNB2 | Chemokine signaling pathway |
| REAC:R-HSA-373080 | 0.0253191001807 | 0.4 | GNB5 GNB2 | Class B/2 (Secretin family receptors) |
| REAC:R-HSA-9009391 | 0.0287045163353 | 0.4 | GNB5 GNB2 | Extra-nuclear estrogen signaling |
| KEGG:04926 | 0.0301730300338 | 0.4 | GNB5 GNB2 | Relaxin signaling pathway |
| KEGG:04728 | 0.030676003082 | 0.4 | GNB5 GNB2 | Dopaminergic synapse |
| REAC:R-HSA-422356 | 0.0313816354582 | 0.4 | GNB5 GNB2 | Regulation of insulin secretion |
| KEGG:04371 | 0.0322094461771 | 0.4 | GNB5 GNB2 | Apelin signaling pathway |
| REAC:R-HSA-416482 | 0.0351349281697 | 0.4 | GNB5 GNB2 | G alpha (12/13) signalling events |
| KEGG:04062 | 0.0353865382697 | 0.4 | GNB5 GNB2 | Chemokine signaling pathway |
| KEGG:04723 | 0.0364781730982 | 0.4 | GNB5 GNB2 | Retrograde endocannabinoid signaling |
| WP:WP4223 | 0.0390434201563 | 0.4 | GNB5 GNB2 | Ras Signaling |
| REAC:R-HSA-418346 | 0.0390979640759 | 0.4 | GNB5 GNB2 | Platelet homeostasis |
| REAC:R-HSA-111885 | 0.0487798927038 | 0.4 | GNB5 GNB2 | Opioid Signalling |
| CORUM:7146 | 0.0499494897235 | 0.2 | GNB5 | GNAS-L-GNB1-GNG1 complex |
| CORUM:7018 | 0.0499494897235 | 0.2 | GNB5 | GNAI1-GNB5-GNGT1 complex |
| CORUM:7015 | 0.0499494897235 | 0.2 | GNB2 | GNAI1-GNB2-GNGT1 complex |
| CORUM:3828 | 0.0499494897235 | 0.2 | PDCL | DRIP78-PHLP complex |
| CORUM:7143 | 0.0499494897235 | 0.2 | GNB2 | GNAS-L-GNB2-GNG1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNB5 | RGS6 | 0.383 | 0.551 | bioplex (RGS6) bioplex_WMM |
| PDCL | GNB5 | 0.374 | 0.546 | bioplex (GNB5) bioplex_WMM |
| RGS9 | GNB5 | 0.053 | 0.3 | bioplex (RGS9) bioplex_WMM |
| PDCL | GNB2 | 0.047 | 0.293 | hein_WMM bioplex (GNB2) bioplex_WMM |
Images
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Complex HuMAP2_03750 has an average edge precision of 0.423 which is ranked 3087 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDCL | HuMAP2_02735 HuMAP2_03750 HuMAP2_04444 HuMAP2_05976 |
| GNB5 | HuMAP2_02735 HuMAP2_03750 HuMAP2_04463 HuMAP2_05976 |
| RGS6 | HuMAP2_02735 HuMAP2_03750 HuMAP2_04463 |
| RGS9 | HuMAP2_01424 HuMAP2_02133 HuMAP2_03750 |
| GNB2 | HuMAP2_02735 HuMAP2_02804 HuMAP2_03216 HuMAP2_03750 HuMAP2_05976 |