hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03755
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAMA5 | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) | UniProt NCBI |
| LAMB2 | Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) | UniProt NCBI |
| AGA | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | UniProt NCBI |
| LAMB4 | Laminin subunit beta-4 (Laminin beta-1-related protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0043256 | 2.03382379613e-05 | 0.75 | LAMA5 LAMB2 LAMB4 | laminin complex |
| KEGG:04512 | 2.03941189943e-05 | 0.75 | LAMA5 LAMB2 LAMB4 | ECM-receptor interaction |
| KEGG:05146 | 2.64684560853e-05 | 0.75 | LAMA5 LAMB2 LAMB4 | Amoebiasis |
| WP:WP4658 | 3.10867203099e-05 | 0.75 | LAMA5 LAMB2 LAMB4 | Small cell lung cancer |
| KEGG:05222 | 3.36411053102e-05 | 0.75 | LAMA5 LAMB2 LAMB4 | Small cell lung cancer |
| KEGG:05145 | 3.59048577419e-05 | 0.75 | LAMA5 LAMB2 LAMB4 | Toxoplasmosis |
| CORUM:2319 | 5.02641999304e-05 | 0.5 | LAMA5 LAMB2 | ITGA6-ITGB4-Laminin10/12 complex |
| KEGG:04510 | 0.000295204681571 | 0.75 | LAMA5 LAMB2 LAMB4 | Focal adhesion |
| WP:WP453 | 0.000352218401684 | 0.5 | LAMA5 LAMB2 | Inflammatory Response Pathway |
| WP:WP4172 | 0.000867148271367 | 0.75 | LAMA5 LAMB2 LAMB4 | PI3K-Akt Signaling Pathway |
| WP:WP244 | 0.000884625784373 | 0.5 | LAMA5 LAMB2 | Alpha 6 Beta 4 signaling pathway |
| KEGG:04151 | 0.00118089914293 | 0.75 | LAMA5 LAMB2 LAMB4 | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.00132804938561 | 0.75 | LAMA5 LAMB2 LAMB4 | Human papillomavirus infection |
| GO:0044420 | 0.00281780772825 | 0.75 | LAMA5 LAMB2 LAMB4 | extracellular matrix component |
| WP:WP2572 | 0.00326331699224 | 0.5 | LAMA5 LAMB2 | Primary Focal Segmental Glomerulosclerosis FSGS |
| REAC:R-HSA-8874081 | 0.00379215175563 | 0.5 | LAMA5 LAMB2 | MET activates PTK2 signaling |
| REAC:R-HSA-3000157 | 0.00436320194063 | 0.5 | LAMA5 LAMB2 | Laminin interactions |
| KEGG:05200 | 0.00437599198048 | 0.75 | LAMA5 LAMB2 LAMB4 | Pathways in cancer |
| GO:0005604 | 0.00587743889796 | 0.75 | LAMA5 LAMB2 LAMB4 | basement membrane |
| REAC:R-HSA-8875878 | 0.00667602194349 | 0.5 | LAMA5 LAMB2 | MET promotes cell motility |
| GO:0043260 | 0.00811409485621 | 0.5 | LAMA5 LAMB2 | laminin-11 complex |
| REAC:R-HSA-3000171 | 0.0159697215039 | 0.5 | LAMA5 LAMB2 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 0.0214457367555 | 0.5 | LAMA5 LAMB2 | ECM proteoglycans |
| REAC:R-HSA-6806834 | 0.0262582706021 | 0.5 | LAMA5 LAMB2 | Signaling by MET |
| WP:WP306 | 0.0290430519819 | 0.5 | LAMA5 LAMB2 | Focal Adhesion |
| GO:0034446 | 0.0297308662285 | 0.75 | LAMA5 LAMB2 LAMB4 | substrate adhesion-dependent cell spreading |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAMB2 | LAMA5 | 0.09 | 0.355 | bioplex_WMM fraction |
| LAMB4 | LAMA5 | 0.027 | 0.229 | fraction |
| LAMA5 | AGA | 0.022 | 0.205 | fraction |
| LAMB2 | AGA | 0.0 | 0.014 | bioplex (AGA) fraction |
Images
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Complex HuMAP2_03755 has an average edge precision of 0.201 which is ranked 6166 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LAMA5 | HuMAP2_01440 HuMAP2_01618 HuMAP2_01839 HuMAP2_03755 HuMAP2_04169 |
| LAMB2 | HuMAP2_01440 HuMAP2_01618 HuMAP2_01839 HuMAP2_03755 HuMAP2_04169 |
| AGA | HuMAP2_01440 HuMAP2_01618 HuMAP2_01839 HuMAP2_03755 |
| LAMB4 | HuMAP2_01440 HuMAP2_01618 HuMAP2_01839 HuMAP2_03755 |