hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03771
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GET4 | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | UniProt NCBI |
| UBL4A | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | UniProt NCBI |
| TRMT5 | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) | UniProt NCBI |
| ASNA1 | ATPase ASNA1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I) | UniProt NCBI |
| BAG6 | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | UniProt NCBI |
| PTBP1 | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | UniProt NCBI |
| ARPP19 | cAMP-regulated phosphoprotein 19 (ARPP-19) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6862 | 3.38154272427e-09 | 0.428571428571 | UBL4A GET4 BAG6 | Bag6-Ubl4A-Trc35 Complex |
| REAC:R-HSA-9609523 | 6.78225759637e-09 | 0.571428571429 | ASNA1 GET4 BAG6 UBL4A | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| GO:0071816 | 1.28035412092e-08 | 0.571428571429 | ASNA1 GET4 BAG6 UBL4A | tail-anchored membrane protein insertion into ER membrane |
| GO:0045048 | 2.98701137129e-08 | 0.571428571429 | ASNA1 GET4 BAG6 UBL4A | protein insertion into ER membrane |
| GO:0071818 | 3.17865016081e-06 | 0.428571428571 | UBL4A GET4 BAG6 | BAT3 complex |
| GO:0072379 | 3.17736949706e-05 | 0.428571428571 | UBL4A GET4 BAG6 | ER membrane insertion complex |
| REAC:R-HSA-9609507 | 5.0692101136e-05 | 0.571428571429 | ASNA1 GET4 BAG6 UBL4A | Protein localization |
| GO:0007029 | 0.000138393555724 | 0.571428571429 | ASNA1 GET4 BAG6 UBL4A | endoplasmic reticulum organization |
| GO:0051205 | 0.000248057665948 | 0.571428571429 | ASNA1 GET4 BAG6 UBL4A | protein insertion into membrane |
| MIRNA:hsa-miR-4786-3p | 0.00262187705264 | 0.428571428571 | PTBP1 UBL4A ARPP19 | hsa-miR-4786-3p |
| GO:0036506 | 0.0283955176165 | 0.285714285714 | BAG6 GET4 | maintenance of unfolded protein |
| GO:1904378 | 0.0283955176165 | 0.285714285714 | BAG6 GET4 | maintenance of unfolded protein involved in ERAD pathway |
| MIRNA:hsa-miR-4799-3p | 0.0498283786114 | 0.285714285714 | UBL4A TRMT5 | hsa-miR-4799-3p |
| CORUM:6079 | 0.0499886427319 | 0.142857142857 | BAG6 | BAG6-HSPA2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBL4A | BAG6 | 1.0 | 0.949 | hein_WMM bioplex (UBL4A) bioplex_WMM boldt hein (BAG6) Malo fraction boldt_WMM |
| GET4 | UBL4A | 1.0 | 0.949 | hein_WMM bioplex (GET4,UBL4A) bioplex_WMM boldt hein (GET4) boldt_WMM |
| GET4 | BAG6 | 1.0 | 0.949 | hein_WMM bioplex (GET4) bioplex_WMM boldt hein (BAG6,GET4) boldt_WMM |
| GET4 | ASNA1 | 0.864 | 0.801 | hein_WMM bioplex (ASNA1,GET4) bioplex_WMM boldt hein (ASNA1,GET4) boldt_WMM |
| UBL4A | ASNA1 | 0.552 | 0.644 | hein_WMM bioplex (ASNA1,UBL4A) bioplex_WMM boldt hein (ASNA1) boldt_WMM |
| BAG6 | ASNA1 | 0.337 | 0.526 | hein_WMM bioplex (ASNA1) bioplex_WMM boldt hein (ASNA1) boldt_WMM |
| PTBP1 | UBL4A | 0.135 | 0.407 | bioplex_WMM youn_WMM fraction |
| ARPP19 | PTBP1 | 0.044 | 0.279 | fraction |
| TRMT5 | PTBP1 | 0.041 | 0.268 | youn_WMM fraction |
| PTBP1 | GET4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PTBP1 | ASNA1 | 0.007 | 0.003 | bioplex_WMM WMM_only treiber_WMM |
| ARPP19 | BAG6 | 0.003 | 0.014 | fraction |
| PTBP1 | BAG6 | 0.0 | 0.002 | bioplex_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_03771 has an average edge precision of 0.446 which is ranked 2905 out of all 6965 complexes.
Related Complexes