hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03772

Confidence: Medium

Genename	Protein Name	Links
HSPB8	Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22)	UniProt NCBI
LZTS2	Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)	UniProt NCBI
TRIM27	Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27)	UniProt NCBI
SIPA1L3	Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)	UniProt NCBI
C2CD5	C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa)	UniProt NCBI
SIPA1L1	Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)	UniProt NCBI
CEP78	Centrosomal protein of 78 kDa (Cep78)	UniProt NCBI
PLEKHG1	Pleckstrin homology domain-containing family G member 1	UniProt NCBI
USP54	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54)	UniProt NCBI
SAMD4B	Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B)	UniProt NCBI
LZTS1	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)	UniProt NCBI
SIPA1L2	Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)	UniProt NCBI
TRAF5	TNF receptor-associated factor 5 (RING finger protein 84)	UniProt NCBI
MPHOSPH9	M-phase phosphoprotein 9	UniProt NCBI
ALMS1	Alstrom syndrome protein 1	UniProt NCBI
FAM83H	Protein FAM83H	UniProt NCBI
TROAP	Tastin (Trophinin-assisting protein) (Trophinin-associated protein)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HPA:005010_22	0.00787246107007	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	bronchus; respiratory epithelial cells[Approved,Medium]
HPA:043030_21	0.00862143823355	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	skin 1; keratinocytes[Approved,Low]
HPA:011030_21	0.0128759739657	0.647058823529	SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 C2CD5 TRIM27 HSPB8 USP54 SAMD4B PLEKHG1	colon; peripheral nerve/ganglion[Approved,Low]
HPA:011020_22	0.0163427554786	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	colon; glandular cells[Approved,Medium]
HPA:008050_21	0.018139703053	0.647058823529	C2CD5 SIPA1L1 LZTS1 SIPA1L2 MPHOSPH9 CEP78 TRIM27 HSPB8 USP54 SAMD4B PLEKHG1	cerebral cortex; neuropil[Approved,Low]
HPA:045010_22	0.0182037883838	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	small intestine; glandular cells[Approved,Medium]
HPA:014020_21	0.0223700729919	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	endometrium 2; glandular cells[Approved,Low]
HPA:016010_21	0.0227638136446	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	esophagus; squamous epithelial cells[Approved,Low]
HPA:015010_22	0.0275589106431	0.647058823529	C2CD5 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 TRIM27 HSPB8 SIPA1L1 SAMD4B PLEKHG1	epididymis; glandular cells[Approved,Medium]
HPA:026020_21	0.0361195981828	0.647058823529	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	liver; hepatocytes[Approved,Low]
HPA:044010_22	0.0376124529011	0.588235294118	SIPA1L1 LZTS1 SIPA1L2 LZTS2 CEP78 TRIM27 HSPB8 USP54 MPHOSPH9 PLEKHG1	skin 2; epidermal cells[Approved,Medium]
HPA:032010_21	0.0383624187641	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	pancreas; exocrine glandular cells[Approved,Low]
HPA:002010_22	0.0402935338442	0.647058823529	SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 C2CD5 TRIM27 HSPB8 USP54 SAMD4B PLEKHG1	appendix; glandular cells[Approved,Medium]
HPA:053010_22	0.0417757685272	0.647058823529	C2CD5 SIPA1L1 LZTS1 SIPA1L2 MPHOSPH9 CEP78 TRIM27 HSPB8 USP54 SAMD4B PLEKHG1	testis; Leydig cells[Approved,Medium]
HPA:014020_22	0.0426510513899	0.588235294118	SIPA1L1 LZTS1 LZTS2 MPHOSPH9 C2CD5 PLEKHG1 HSPB8 USP54 SAMD4B SIPA1L2	endometrium 2; glandular cells[Approved,Medium]
HPA:004030_21	0.0430472283236	0.647058823529	C2CD5 SIPA1L1 LZTS1 SIPA1L2 MPHOSPH9 CEP78 TRIM27 HSPB8 USP54 SAMD4B PLEKHG1	breast; myoepithelial cells[Approved,Low]
HPA:011030_20	0.0438294022532	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	colon; peripheral nerve/ganglion[Approved,Not detected]
HPA:057010_22	0.0484783551296	0.647058823529	C2CD5 SIPA1L1 LZTS1 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	urinary bladder; urothelial cells[Approved,Medium]
HPA:029010_21	0.0494465802764	0.705882352941	C2CD5 SIPA1L1 LZTS1 SIPA1L2 LZTS2 MPHOSPH9 CEP78 PLEKHG1 HSPB8 USP54 SAMD4B TRIM27	nasopharynx; respiratory epithelial cells[Approved,Low]

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SIPA1L2	LZTS2	0.999	0.948	youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM
LZTS2	LZTS1	0.989	0.902	youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM
LZTS2	SIPA1L3	0.972	0.885	hein_WMM youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM
LZTS2	SIPA1L1	0.609	0.674	hein_WMM youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM boldt_WMM
LZTS2	TRAF5	0.283	0.488	youn (LZTS2) youn_WMM bioplex () gupta_WMM bioplex_WMM
LZTS2	TROAP	0.069	0.349	youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM
TRIM27	LZTS2	0.059	0.33	hein_WMM youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM
LZTS2	HSPB8	0.053	0.301	bioplex () bioplex_WMM
LZTS2	FAM83H	0.051	0.3	hein_WMM youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM boldt_WMM
LZTS2	ALMS1	0.047	0.292	youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM
CEP78	LZTS2	0.044	0.274	hein_WMM youn (LZTS2) bioplex (LZTS2) bioplex_WMM hein (CEP78)
USP54	LZTS2	0.042	0.269	youn (LZTS2) bioplex_WMM youn_WMM gupta_WMM boldt_WMM
LZTS2	C2CD5	0.032	0.24	youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM
LZTS2	PLEKHG1	0.026	0.22	youn (LZTS2) youn_WMM gupta_WMM
LZTS2	MPHOSPH9	0.024	0.211	youn (LZTS2) youn_WMM gupta_WMM
SAMD4B	SIPA1L2	0.021	0.186	youn (SAMD4B) youn_WMM gupta_WMM boldt_WMM
SIPA1L3	SIPA1L1	0.016	0.162	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
SIPA1L2	SIPA1L1	0.012	0.147	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
SIPA1L2	FAM83H	0.011	0.141	bioplex_WMM youn_WMM gupta_WMM WMM_only
SIPA1L2	SIPA1L3	0.009	0.09	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
LZTS1	SIPA1L1	0.009	0.093	bioplex_WMM youn_WMM WMM_only
LZTS1	SIPA1L3	0.008	0.094	bioplex_WMM youn_WMM WMM_only
SAMD4B	PLEKHG1	0.008	0.088	youn (SAMD4B) youn_WMM gupta_WMM
SIPA1L2	LZTS1	0.008	0.089	bioplex_WMM youn_WMM WMM_only
LZTS1	C2CD5	0.008	0.066	bioplex_WMM youn_WMM WMM_only
USP54	TROAP	0.008	0.066	bioplex_WMM youn_WMM gupta_WMM WMM_only
SIPA1L3	C2CD5	0.008	0.067	bioplex_WMM youn_WMM WMM_only
SIPA1L2	PLEKHG1	0.008	0.068	youn_WMM gupta_WMM WMM_only
SIPA1L1	PLEKHG1	0.008	0.055	youn_WMM gupta_WMM WMM_only
LZTS1	TROAP	0.008	0.04	bioplex_WMM youn_WMM WMM_only
FAM83H	TROAP	0.008	0.044	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
ALMS1	MPHOSPH9	0.008	0.043	youn_WMM gupta_WMM WMM_only
SIPA1L3	TROAP	0.008	0.041	bioplex_WMM youn_WMM gupta_WMM WMM_only
SIPA1L2	TRAF5	0.008	0.036	youn_WMM gupta_WMM WMM_only bioplex_WMM
SIPA1L2	USP54	0.008	0.035	bioplex_WMM youn_WMM gupta_WMM WMM_only
PLEKHG1	MPHOSPH9	0.008	0.033	youn_WMM gupta_WMM WMM_only
SIPA1L1	C2CD5	0.008	0.033	bioplex_WMM youn_WMM WMM_only
SIPA1L2	TROAP	0.008	0.022	bioplex_WMM youn_WMM gupta_WMM WMM_only
SIPA1L3	PLEKHG1	0.008	0.023	youn_WMM gupta_WMM WMM_only
TRAF5	LZTS1	0.008	0.026	youn_WMM WMM_only bioplex_WMM
ALMS1	PLEKHG1	0.008	0.029	youn_WMM gupta_WMM WMM_only
SAMD4B	TRIM27	0.008	0.029	youn (SAMD4B) youn_WMM
SAMD4B	USP54	0.008	0.015	youn_WMM gupta_WMM WMM_only
USP54	MPHOSPH9	0.008	0.017	youn_WMM gupta_WMM WMM_only
USP54	PLEKHG1	0.008	0.019	youn_WMM gupta_WMM WMM_only
TROAP	SIPA1L1	0.008	0.014	bioplex_WMM youn_WMM gupta_WMM WMM_only
ALMS1	SIPA1L3	0.008	0.007	bioplex_WMM youn_WMM gupta_WMM WMM_only
FAM83H	HSPB8	0.008	0.007	bioplex (HSPB8) bioplex_WMM
TRAF5	SIPA1L1	0.008	0.011	youn_WMM gupta_WMM WMM_only bioplex_WMM
SIPA1L2	MPHOSPH9	0.008	0.015	youn_WMM gupta_WMM WMM_only
HSPB8	LZTS1	0.007	0.011	WMM_only bioplex_WMM
SIPA1L2	ALMS1	0.007	0.011	bioplex_WMM youn_WMM gupta_WMM WMM_only
SIPA1L1	MPHOSPH9	0.007	0.004	youn_WMM gupta_WMM WMM_only
FAM83H	MPHOSPH9	0.007	0.005	youn_WMM gupta_WMM WMM_only
SIPA1L2	C2CD5	0.007	0.012	bioplex_WMM youn_WMM WMM_only
SIPA1L3	MPHOSPH9	0.007	0.005	youn_WMM gupta_WMM WMM_only
TROAP	C2CD5	0.007	0.007	bioplex_WMM youn_WMM WMM_only
FAM83H	PLEKHG1	0.007	0.004	youn_WMM gupta_WMM WMM_only
SAMD4B	TROAP	0.007	0.012	youn_WMM gupta_WMM WMM_only
ALMS1	SIPA1L1	0.007	0.003	bioplex_WMM youn_WMM gupta_WMM WMM_only
TRAF5	PLEKHG1	0.007	0.003	youn_WMM gupta_WMM WMM_only
SIPA1L2	HSPB8	0.007	0.008	WMM_only bioplex_WMM
HSPB8	TRAF5	0.007	0.008	WMM_only bioplex_WMM
USP54	TRAF5	0.007	0.009	youn_WMM gupta_WMM WMM_only
CEP78	LZTS1	0.007	0.009	bioplex_WMM youn_WMM WMM_only
SAMD4B	FAM83H	0.007	0.008	youn_WMM gupta_WMM WMM_only
TRIM27	MPHOSPH9	0.007	0.011	youn_WMM gupta_WMM WMM_only
FAM83H	TRAF5	0.007	0.006	youn_WMM gupta_WMM WMM_only
HSPB8	SIPA1L1	0.007	0.015	WMM_only bioplex_WMM
TRIM27	PLEKHG1	0.007	0.008	youn_WMM WMM_only
USP54	ALMS1	0.007	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only
SAMD4B	SIPA1L1	0.007	0.005	youn (SAMD4B) youn_WMM gupta_WMM boldt_WMM
SAMD4B	TRAF5	0.007	0.005	youn_WMM WMM_only
C2CD5	MPHOSPH9	0.007	0.007	youn_WMM gupta_WMM WMM_only
ALMS1	C2CD5	0.007	0.004	bioplex_WMM youn_WMM gupta_WMM WMM_only
TRIM27	LZTS1	0.007	0.004	bioplex_WMM youn_WMM WMM_only
TRAF5	MPHOSPH9	0.007	0.005	youn_WMM gupta_WMM WMM_only
TROAP	PLEKHG1	0.007	0.006	youn_WMM gupta_WMM WMM_only
FAM83H	SIPA1L3	0.007	0.005	youn_WMM gupta_WMM WMM_only
C2CD5	PLEKHG1	0.007	0.004	youn_WMM WMM_only
TRAF5	TROAP	0.007	0.003	youn_WMM WMM_only
TRIM27	SIPA1L1	0.007	0.007	bioplex_WMM youn_WMM WMM_only boldt_WMM
ALMS1	TRAF5	0.007	0.001	youn_WMM gupta_WMM WMM_only
LZTS1	PLEKHG1	0.007	0.005	youn_WMM WMM_only
FAM83H	LZTS1	0.007	0.008	youn_WMM WMM_only
CEP78	SIPA1L1	0.007	0.004	bioplex_WMM youn_WMM gupta_WMM WMM_only
USP54	SIPA1L1	0.007	0.003	youn_WMM gupta_WMM WMM_only boldt_WMM
USP54	SIPA1L3	0.007	0.001	youn_WMM gupta_WMM WMM_only
TRIM27	TRAF5	0.007	0.004	youn_WMM WMM_only
SAMD4B	C2CD5	0.007	0.004	youn_WMM WMM_only
FAM83H	SIPA1L1	0.007	0.006	youn_WMM gupta_WMM WMM_only boldt_WMM
USP54	C2CD5	0.007	0.004	youn_WMM WMM_only
TRAF5	SIPA1L3	0.007	0.001	youn_WMM gupta_WMM WMM_only
LZTS1	MPHOSPH9	0.007	0.007	youn_WMM WMM_only
CEP78	PLEKHG1	0.007	0.005	youn_WMM gupta_WMM WMM_only
CEP78	TRAF5	0.007	0.002	youn_WMM WMM_only
USP54	LZTS1	0.007	0.007	youn_WMM WMM_only
CEP78	MPHOSPH9	0.007	0.003	youn_WMM gupta_WMM WMM_only
SAMD4B	LZTS1	0.007	0.0	youn_WMM WMM_only
TROAP	MPHOSPH9	0.007	0.0	youn_WMM gupta_WMM WMM_only
ALMS1	LZTS1	0.007	0.005	bioplex_WMM youn_WMM WMM_only
TRAF5	C2CD5	0.007	0.001	youn_WMM WMM_only
SAMD4B	CEP78	0.007	0.004	youn_WMM WMM_only
HSPB8	MPHOSPH9	0.007	0.002	gupta_WMM WMM_only
SIPA1L2	TRIM27	0.007	0.005	bioplex_WMM boldt youn_WMM boldt_WMM
ALMS1	TROAP	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
CEP78	C2CD5	0.007	0.005	bioplex_WMM youn_WMM WMM_only
SAMD4B	LZTS2	0.007	0.003	youn (LZTS2,SAMD4B) youn_WMM gupta_WMM
USP54	FAM83H	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
SIPA1L2	CEP78	0.007	0.005	bioplex_WMM youn_WMM WMM_only
CEP78	TROAP	0.007	0.002	bioplex_WMM youn_WMM WMM_only
CEP78	SIPA1L3	0.007	0.004	hein_WMM bioplex_WMM youn_WMM WMM_only
FAM83H	C2CD5	0.007	0.006	hein_WMM youn_WMM WMM_only
TRIM27	TROAP	0.006	0.002	bioplex_WMM youn_WMM WMM_only
TRIM27	SIPA1L3	0.006	0.004	hein_WMM bioplex_WMM youn_WMM WMM_only
ALMS1	FAM83H	0.006	0.003	bioplex_WMM youn_WMM gupta_WMM WMM_only
SAMD4B	MPHOSPH9	0.006	0.011	youn (SAMD4B) youn_WMM gupta_WMM
TRIM27	C2CD5	0.006	0.006	hein_WMM bioplex_WMM youn_WMM WMM_only
SAMD4B	ALMS1	0.006	0.007	youn (SAMD4B) youn_WMM gupta_WMM
CEP78	ALMS1	0.006	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
SAMD4B	SIPA1L3	0.006	0.008	youn (SAMD4B) youn_WMM gupta_WMM boldt_WMM
CEP78	USP54	0.006	0.009	bioplex_WMM youn_WMM WMM_only
TRIM27	USP54	0.006	0.009	bioplex_WMM youn_WMM WMM_only
TRIM27	ALMS1	0.005	0.013	bioplex_WMM youn_WMM gupta_WMM WMM_only
CEP78	FAM83H	0.005	0.007	bioplex_WMM youn_WMM WMM_only
ALMS1	HSPB8	0.004	0.014	bioplex (HSPB8) bioplex_WMM gupta_WMM
TRIM27	FAM83H	0.004	0.01	bioplex_WMM youn_WMM WMM_only
TRIM27	CEP78	0.004	0.014	hein_WMM bioplex_WMM youn_WMM WMM_only

Images

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Complex HuMAP2_03772 has an average edge precision of 0.071 which is ranked 6970 out of all 6965 complexes.

Related Complexes

Genename	Complexes
HSPB8	HuMAP2_00689 HuMAP2_03772 HuMAP2_06990
LZTS2	HuMAP2_00618 HuMAP2_02173 HuMAP2_03011 HuMAP2_03772
TRIM27	HuMAP2_00095 HuMAP2_03772 HuMAP2_06142
SIPA1L3	HuMAP2_02173 HuMAP2_03772 HuMAP2_04789 HuMAP2_05933
C2CD5	HuMAP2_03535 HuMAP2_03772 HuMAP2_04184
SIPA1L1	HuMAP2_02675 HuMAP2_03011 HuMAP2_03772
CEP78	HuMAP2_00618 HuMAP2_03772 HuMAP2_05261
PLEKHG1	HuMAP2_03772
USP54	HuMAP2_00618 HuMAP2_03772 HuMAP2_06786
SAMD4B	HuMAP2_00035 HuMAP2_00690 HuMAP2_02612 HuMAP2_03772
LZTS1	HuMAP2_02173 HuMAP2_02337 HuMAP2_03011 HuMAP2_03772
SIPA1L2	HuMAP2_00035 HuMAP2_00618 HuMAP2_02173 HuMAP2_02612 HuMAP2_03011 HuMAP2_03772
TRAF5	HuMAP2_01085 HuMAP2_01714 HuMAP2_01880 HuMAP2_03401 HuMAP2_03772 HuMAP2_06084 HuMAP2_06302
MPHOSPH9	HuMAP2_03772
ALMS1	HuMAP2_00618 HuMAP2_01481 HuMAP2_03324 HuMAP2_03772 HuMAP2_04653
FAM83H	HuMAP2_00673 HuMAP2_00796 HuMAP2_03772 HuMAP2_06349
TROAP	HuMAP2_02431 HuMAP2_03772

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03772