hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03774
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DCLRE1C | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | UniProt NCBI |
| TRIM26 | Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173) | UniProt NCBI |
| PYHIN1 | Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X) | UniProt NCBI |
| ZSWIM8 | Zinc finger SWIM domain-containing protein 8 | UniProt NCBI |
| SPINK5 | Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001019 | 0.0275312401623 | 0.4 | DCLRE1C SPINK5 | Erythroderma |
| HP:0001880 | 0.0325153883173 | 0.4 | DCLRE1C SPINK5 | Eosinophilia |
| HP:0020064 | 0.0325153883173 | 0.4 | DCLRE1C SPINK5 | Abnormal eosinophil count |
| HP:0001879 | 0.0360671162807 | 0.4 | DCLRE1C SPINK5 | Abnormal eosinophil morphology |
| CORUM:360 | 0.0499494897235 | 0.2 | DCLRE1C | Artemis-DNA-PK complex |
| CORUM:361 | 0.0499494897235 | 0.2 | DCLRE1C | Artemis-DNA-PK complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DCLRE1C | ZSWIM8 | 0.335 | 0.527 | bioplex (DCLRE1C) bioplex_WMM |
| DCLRE1C | TRIM26 | 0.211 | 0.459 | bioplex (DCLRE1C) bioplex_WMM |
| PYHIN1 | TRIM26 | 0.135 | 0.407 | bioplex (PYHIN1) bioplex_WMM |
| PYHIN1 | SPINK5 | 0.032 | 0.242 | bioplex (PYHIN1) bioplex_WMM |
| TRIM26 | SPINK5 | 0.008 | 0.038 | bioplex_WMM WMM_only |
| ZSWIM8 | TRIM26 | 0.007 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_03774 has an average edge precision of 0.28 which is ranked 4879 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DCLRE1C | HuMAP2_03622 HuMAP2_03774 HuMAP2_03872 |
| TRIM26 | HuMAP2_03622 HuMAP2_03774 HuMAP2_06273 |
| PYHIN1 | HuMAP2_03622 HuMAP2_03774 HuMAP2_06273 |
| ZSWIM8 | HuMAP2_03622 HuMAP2_03774 HuMAP2_04762 |
| SPINK5 | HuMAP2_03774 HuMAP2_05627 |