hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03776
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| P3H1 | Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) | UniProt NCBI |
| CRTAP | Cartilage-associated protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003783 | 2.00365960613e-05 | 1.0 | CRTAP P3H1 | Externally rotated/abducted legs |
| HP:0005855 | 0.000303888373596 | 1.0 | CRTAP P3H1 | Multiple prenatal fractures |
| GO:1901874 | 0.000450823411379 | 1.0 | CRTAP P3H1 | negative regulation of post-translational protein modification |
| HP:0002953 | 0.000921683418819 | 1.0 | CRTAP P3H1 | Vertebral compression fractures |
| GO:1901873 | 0.00135247023414 | 1.0 | CRTAP P3H1 | regulation of post-translational protein modification |
| HP:0004331 | 0.00135580966681 | 1.0 | CRTAP P3H1 | Decreased skull ossification |
| HP:0002703 | 0.00198696244274 | 1.0 | CRTAP P3H1 | Abnormality of skull ossification |
| HP:0002645 | 0.00287525153479 | 1.0 | CRTAP P3H1 | Wormian bones |
| REAC:R-HSA-1650814 | 0.00316917126735 | 1.0 | CRTAP P3H1 | Collagen biosynthesis and modifying enzymes |
| HP:0000270 | 0.00514272632239 | 1.0 | CRTAP P3H1 | Delayed cranial suture closure |
| REAC:R-HSA-1474290 | 0.00584226918984 | 1.0 | CRTAP P3H1 | Collagen formation |
| HP:0000260 | 0.00716308309191 | 1.0 | CRTAP P3H1 | Wide anterior fontanel |
| HP:0000311 | 0.00877602907484 | 1.0 | CRTAP P3H1 | Round face |
| HP:0008873 | 0.0113640893994 | 1.0 | CRTAP P3H1 | Disproportionate short-limb short stature |
| HP:0000236 | 0.0124928176442 | 1.0 | CRTAP P3H1 | Abnormality of the anterior fontanelle |
| HP:0003498 | 0.0172014177186 | 1.0 | CRTAP P3H1 | Disproportionate short stature |
| HP:0002757 | 0.0211319299793 | 1.0 | CRTAP P3H1 | Recurrent fractures |
| HP:0000239 | 0.0288727349243 | 1.0 | CRTAP P3H1 | Large fontanelles |
| HP:0002979 | 0.0358354520556 | 1.0 | CRTAP P3H1 | Bowing of the legs |
| HP:0011328 | 0.0388309231668 | 1.0 | CRTAP P3H1 | Abnormality of fontanelles |
| HP:0002659 | 0.0435495415392 | 1.0 | CRTAP P3H1 | Increased susceptibility to fractures |
| HP:0003784 | 0.0497341708567 | 0.5 | P3H1 | Type 1 collagen overmodification |
| HP:0004960 | 0.0497341708567 | 0.5 | CRTAP | Absent pulmonary artery |
| HP:0011862 | 0.0497341708567 | 0.5 | P3H1 | Abnormal bone collagen fibril morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRTAP | P3H1 | 1.0 | 0.949 | hein_WMM bioplex (P3H1) bioplex_WMM Malo fraction treiber_WMM |
Images
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Complex HuMAP2_03776 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| P3H1 | HuMAP2_01764 HuMAP2_02122 HuMAP2_03776 |
| CRTAP | HuMAP2_01409 HuMAP2_03776 |