hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03783
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MEX3B | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | UniProt NCBI |
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 5.40157631853e-09 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 1.13404535396e-07 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | PI5P Regulates TP53 Acetylation |
| REAC:R-HSA-6804758 | 5.47542005033e-06 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Regulation of TP53 Activity through Acetylation |
| KEGG:00562 | 1.5327283042e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Inositol phosphate metabolism |
| GO:2000786 | 2.03382379613e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of autophagosome assembly |
| REAC:R-HSA-1660499 | 2.33046531546e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Synthesis of PIPs at the plasma membrane |
| KEGG:04070 | 3.36411053102e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Phosphatidylinositol signaling system |
| GO:0044090 | 5.99161085695e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of vacuole organization |
| REAC:R-HSA-6811558 | 7.05209067921e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| WP:WP51 | 8.39876098155e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Regulation of Actin Cytoskeleton |
| REAC:R-HSA-199418 | 9.45884271068e-05 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-1483255 | 0.000102349667815 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | PI Metabolism |
| KEGG:04810 | 0.000285912023079 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Regulation of actin cytoskeleton |
| REAC:R-HSA-5633007 | 0.000847823442334 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Regulation of TP53 Activity |
| GO:2000785 | 0.00132566605022 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | regulation of autophagosome assembly |
| REAC:R-HSA-1483257 | 0.00136676597405 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Phospholipid metabolism |
| REAC:R-HSA-1257604 | 0.00250140055192 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | PIP3 activates AKT signaling |
| GO:0044088 | 0.0025894674696 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | regulation of vacuole organization |
| REAC:R-HSA-9006925 | 0.00399488218563 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Intracellular signaling by second messengers |
| GO:0016239 | 0.0062689516986 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of macroautophagy |
| GO:1902117 | 0.00898751047669 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of organelle assembly |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | Transcriptional Regulation by TP53 |
| GO:0005776 | 0.0143823911437 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | autophagosome |
| GO:0000045 | 0.0286174056273 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | autophagosome assembly |
| GO:1905037 | 0.0297308662285 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | autophagosome organization |
| GO:0014066 | 0.037022076332 | 0.75 | PIP4K2B PIP4K2C PIP4K2A | regulation of phosphatidylinositol 3-kinase signaling |
| GO:0016308 | 0.0405595771497 | 0.5 | PIP4K2B PIP4K2A | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MIRNA:hsa-miR-6729-3p | 0.0497427802251 | 0.5 | PIP4K2B PIP4K2C | hsa-miR-6729-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIP4K2A | PIP4K2C | 1.0 | 0.949 | hein_WMM bioplex (PIP4K2A) bioplex_WMM boldt youn_WMM hein (PIP4K2C) gupta_WMM boldt_WMM |
| PIP4K2B | PIP4K2A | 0.999 | 0.949 | hein_WMM bioplex (PIP4K2A) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIP4K2A | MEX3B | 0.788 | 0.757 | youn (MEX3B) bioplex (PIP4K2A) bioplex_WMM |
| PIP4K2B | PIP4K2C | 0.392 | 0.554 | hein_WMM bioplex_WMM boldt youn_WMM hein (PIP4K2C) gupta_WMM boldt_WMM |
| PIP4K2B | MEX3B | 0.006 | 0.005 | youn (MEX3B) bioplex_WMM |
| PIP4K2C | MEX3B | 0.005 | 0.01 | youn (MEX3B) bioplex_WMM gupta_WMM |
Images
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Complex HuMAP2_03783 has an average edge precision of 0.537 which is ranked 2292 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MEX3B | HuMAP2_03783 HuMAP2_04286 HuMAP2_04916 HuMAP2_05952 |
| PIP4K2A | HuMAP2_02924 HuMAP2_03783 HuMAP2_06570 |
| PIP4K2B | HuMAP2_01753 HuMAP2_02385 HuMAP2_02924 HuMAP2_03783 HuMAP2_04594 HuMAP2_06570 |
| PIP4K2C | HuMAP2_02924 HuMAP2_03783 HuMAP2_04594 HuMAP2_06570 |