hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03784
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BLOC1S1 | Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (GCN5-like protein 1) (Protein RT14) | UniProt NCBI |
| LAMTOR2 | Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3) | UniProt NCBI |
| LAMTOR3 | Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1) | UniProt NCBI |
| LAMTOR1 | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | UniProt NCBI |
| ODF2L | Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like) | UniProt NCBI |
| LAMTOR5 | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | UniProt NCBI |
| BORCS8 | BLOC-1-related complex subunit 8 (MEF2B neighbor) | UniProt NCBI |
| KXD1 | KxDL motif-containing protein 1 | UniProt NCBI |
| BORCS6 | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | UniProt NCBI |
| CCDC57 | Coiled-coil domain-containing protein 57 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7545 | 5.3296507144e-10 | 0.4 | BLOC1S1 BORCS8 BORCS6 KXD1 | BORC complex |
| CORUM:6888 | 7.60666713655e-09 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| GO:0071986 | 7.67964804112e-08 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Ragulator complex |
| REAC:R-HSA-166208 | 1.55892494361e-07 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | mTORC1-mediated signalling |
| GO:0099078 | 3.58152528008e-07 | 0.4 | BLOC1S1 BORCS8 BORCS6 KXD1 | BORC complex |
| REAC:R-HSA-380972 | 4.3550576894e-07 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 1.74328755306e-06 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | mTOR signalling |
| REAC:R-HSA-8943724 | 8.32359312483e-06 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Regulation of PTEN gene transcription |
| REAC:R-HSA-5628897 | 3.30799313005e-05 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-1632852 | 4.64509548135e-05 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Macroautophagy |
| KEGG:04150 | 8.08779574958e-05 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | mTOR signaling pathway |
| CORUM:5226 | 9.0534767973e-05 | 0.2 | LAMTOR3 LAMTOR2 | p14-Mp1-ERK2 complex |
| CORUM:5222 | 9.0534767973e-05 | 0.2 | LAMTOR3 LAMTOR2 | p14-Mp1-MEK1 complex |
| REAC:R-HSA-9612973 | 9.17885449236e-05 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Autophagy |
| GO:0071230 | 0.000207683806831 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | cellular response to amino acid stimulus |
| GO:0032008 | 0.000235299011022 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | positive regulation of TOR signaling |
| REAC:R-HSA-6807070 | 0.000271888746308 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | PTEN Regulation |
| GO:0043200 | 0.000416645725181 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | response to amino acid |
| GO:0032418 | 0.000901183762621 | 0.4 | KXD1 LAMTOR1 BORCS6 BLOC1S1 | lysosome localization |
| GO:0031902 | 0.00171872239287 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | late endosome membrane |
| REAC:R-HSA-1257604 | 0.00207452637116 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.00383995503219 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Intracellular signaling by second messengers |
| GO:0032006 | 0.00790610358082 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | regulation of TOR signaling |
| HPA:011020_23 | 0.0102814277273 | 0.6 | CCDC57 LAMTOR1 BLOC1S1 BORCS8 LAMTOR2 LAMTOR5 | colon; glandular cells[Approved,High] |
| HPA:033010_23 | 0.0111502074149 | 0.5 | BLOC1S1 CCDC57 LAMTOR1 LAMTOR5 LAMTOR2 | parathyroid gland; glandular cells[Approved,High] |
| REAC:R-HSA-3700989 | 0.0115134084843 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Transcriptional Regulation by TP53 |
| GO:0031929 | 0.0145340987686 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | TOR signaling |
| CORUM:0000000 | 0.0163530596685 | 0.8 | BLOC1S1 LAMTOR5 LAMTOR3 LAMTOR1 KXD1 BORCS8 LAMTOR2 BORCS6 | CORUM root |
| GO:0071229 | 0.0179524301545 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | cellular response to acid chemical |
| HPA:014010_22 | 0.0179759331361 | 0.5 | BORCS8 CCDC57 LAMTOR1 LAMTOR5 LAMTOR2 | endometrium 2; cells in endometrial stroma[Approved,Medium] |
| GO:0005765 | 0.0197421800878 | 0.5 | BLOC1S1 LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | lysosomal membrane |
| GO:0098852 | 0.0197421800878 | 0.5 | BLOC1S1 LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | lytic vacuole membrane |
| HPA:055010_23 | 0.0264809619476 | 0.5 | BLOC1S1 CCDC57 LAMTOR1 LAMTOR5 LAMTOR2 | thyroid gland; glandular cells[Approved,High] |
| HPA:047010 | 0.0279034836599 | 1.0 | BLOC1S1 LAMTOR5 CCDC57 LAMTOR3 BORCS8 LAMTOR1 ODF2L KXD1 LAMTOR2 BORCS6 | soft tissue 1; adipocytes |
| HPA:011030 | 0.0280421457433 | 1.0 | BLOC1S1 LAMTOR5 CCDC57 LAMTOR3 BORCS8 LAMTOR1 ODF2L KXD1 LAMTOR2 BORCS6 | colon; peripheral nerve/ganglion |
| HPA:002020_22 | 0.0337098570494 | 0.6 | CCDC57 LAMTOR1 BLOC1S1 BORCS8 LAMTOR2 LAMTOR5 | appendix; lymphoid tissue[Approved,Medium] |
| GO:0005774 | 0.0371997977312 | 0.5 | BLOC1S1 LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | vacuolar membrane |
| HPA:009010_23 | 0.040163324649 | 0.4 | CCDC57 LAMTOR1 LAMTOR5 LAMTOR2 | cervix, uterine; glandular cells[Approved,High] |
| REAC:R-HSA-8953897 | 0.0427342471261 | 0.4 | LAMTOR3 LAMTOR1 LAMTOR5 LAMTOR2 | Cellular responses to external stimuli |
| HPA:028010_22 | 0.0465100604573 | 0.6 | CCDC57 LAMTOR1 BLOC1S1 KXD1 LAMTOR2 LAMTOR5 | lymph node; germinal center cells[Approved,Medium] |
| HPA:033010_22 | 0.0487921441617 | 0.7 | BLOC1S1 LAMTOR5 CCDC57 KXD1 BORCS8 LAMTOR2 LAMTOR1 | parathyroid gland; glandular cells[Approved,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BORCS6 | BORCS8 | 0.95 | 0.858 | bioplex (BORCS6) bioplex_WMM |
| ODF2L | BORCS6 | 0.949 | 0.858 | bioplex (BORCS6) bioplex_WMM |
| BORCS6 | KXD1 | 0.929 | 0.846 | bioplex (BORCS6) bioplex_WMM |
| BORCS6 | LAMTOR2 | 0.922 | 0.843 | bioplex (BORCS6) bioplex_WMM |
| LAMTOR3 | BORCS6 | 0.761 | 0.749 | bioplex (BORCS6) bioplex_WMM |
| LAMTOR1 | BORCS6 | 0.753 | 0.747 | bioplex (BORCS6) bioplex_WMM |
| BORCS6 | BLOC1S1 | 0.75 | 0.743 | bioplex (BORCS6) bioplex_WMM |
| LAMTOR1 | LAMTOR3 | 0.193 | 0.446 | bioplex_WMM fraction |
| LAMTOR5 | BORCS6 | 0.113 | 0.38 | bioplex (BORCS6) bioplex_WMM |
| CCDC57 | BORCS6 | 0.049 | 0.293 | bioplex (BORCS6) bioplex_WMM |
| LAMTOR5 | LAMTOR1 | 0.048 | 0.294 | hein_WMM bioplex_WMM fraction |
| BORCS8 | BLOC1S1 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| BORCS8 | KXD1 | 0.01 | 0.131 | bioplex_WMM WMM_only |
| CCDC57 | BORCS8 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| ODF2L | CCDC57 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| KXD1 | BLOC1S1 | 0.009 | 0.101 | bioplex_WMM gupta_WMM WMM_only |
| ODF2L | BORCS8 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CCDC57 | BLOC1S1 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| LAMTOR5 | CCDC57 | 0.008 | 0.094 | bioplex_WMM WMM_only |
| CCDC57 | KXD1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| LAMTOR5 | BORCS8 | 0.008 | 0.078 | bioplex_WMM WMM_only |
| ODF2L | BLOC1S1 | 0.008 | 0.074 | bioplex_WMM WMM_only |
| LAMTOR5 | ODF2L | 0.008 | 0.072 | bioplex_WMM WMM_only |
| ODF2L | KXD1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| LAMTOR3 | CCDC57 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| LAMTOR1 | BORCS8 | 0.008 | 0.033 | hein_WMM bioplex_WMM WMM_only |
| LAMTOR1 | CCDC57 | 0.008 | 0.022 | bioplex_WMM WMM_only |
| LAMTOR3 | BORCS8 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| LAMTOR3 | ODF2L | 0.008 | 0.012 | bioplex_WMM WMM_only |
| LAMTOR5 | BLOC1S1 | 0.008 | 0.008 | bioplex_WMM WMM_only |
| LAMTOR5 | KXD1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| LAMTOR1 | ODF2L | 0.007 | 0.008 | bioplex_WMM WMM_only |
| CCDC57 | LAMTOR2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| LAMTOR3 | BLOC1S1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| LAMTOR3 | KXD1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| LAMTOR2 | BORCS8 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| ODF2L | LAMTOR2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| LAMTOR1 | BLOC1S1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| LAMTOR1 | KXD1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| LAMTOR5 | LAMTOR3 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| LAMTOR5 | LAMTOR2 | 0.007 | 0.005 | hein_WMM bioplex_WMM WMM_only |
| LAMTOR2 | BLOC1S1 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| LAMTOR2 | KXD1 | 0.006 | 0.007 | bioplex_WMM WMM_only |
| LAMTOR1 | LAMTOR2 | 0.0 | 0.017 | hein_WMM bioplex_WMM WMM_only |
| LAMTOR3 | LAMTOR2 | 0.0 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03784 has an average edge precision of 0.19 which is ranked 6310 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BLOC1S1 | HuMAP2_03784 |
| LAMTOR2 | HuMAP2_02266 HuMAP2_02685 HuMAP2_03784 |
| LAMTOR3 | HuMAP2_01885 HuMAP2_02685 HuMAP2_03784 |
| LAMTOR1 | HuMAP2_01018 HuMAP2_01885 HuMAP2_02685 HuMAP2_03784 |
| ODF2L | HuMAP2_02266 HuMAP2_02685 HuMAP2_03784 |
| LAMTOR5 | HuMAP2_01018 HuMAP2_01885 HuMAP2_02685 HuMAP2_03784 |
| BORCS8 | HuMAP2_02685 HuMAP2_03784 |
| KXD1 | HuMAP2_03784 |
| BORCS6 | HuMAP2_02266 HuMAP2_02685 HuMAP2_03784 |
| CCDC57 | HuMAP2_02266 HuMAP2_02685 HuMAP2_03784 |