hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03789
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WASHC3 | WASH complex subunit 3 (Coiled-coil domain-containing protein 53) | UniProt NCBI |
| ULK1 | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | UniProt NCBI |
| ATG13 | Autophagy-related protein 13 | UniProt NCBI |
| MGAT4A | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form] | UniProt NCBI |
| WASH3P | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6229 | 1.50819606993e-05 | 0.5 | ATG13 ULK1 | ULK1-ATG13-RB1CC1 complex |
| CORUM:6232 | 3.01612206104e-05 | 0.5 | ATG13 ULK1 | ULK1-ATG13-RB1CC1-ATG101 complex |
| CORUM:6816 | 3.01612206104e-05 | 0.5 | ATG13 ULK1 | ULK1-ATG13-ATG14-PIK3C3 complex |
| CORUM:7091 | 3.01612206104e-05 | 0.5 | ATG13 ULK1 | FIP200-ULK1-ATG13-ATG101 complex |
| CORUM:7065 | 0.000105535916717 | 0.5 | ATG13 ULK1 | WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex |
| WP:WP3844 | 0.000729007032317 | 0.5 | ATG13 ULK1 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| WP:WP4577 | 0.00151155524127 | 0.5 | ATG13 ULK1 | Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway |
| WP:WP615 | 0.00652808434915 | 0.5 | ATG13 ULK1 | Senescence and Autophagy in Cancer |
| KEGG:04211 | 0.00660658678392 | 0.5 | ATG13 ULK1 | Longevity regulating pathway |
| KEGG:04140 | 0.0173825101547 | 0.5 | ATG13 ULK1 | Autophagy - animal |
| REAC:R-HSA-1632852 | 0.0373320991746 | 0.5 | ATG13 ULK1 | Macroautophagy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WASHC3 | WASH3P | 0.993 | 0.918 | bioplex (WASHC3) bioplex_WMM boldt_WMM |
| WASHC3 | MGAT4A | 0.606 | 0.672 | bioplex (WASHC3) bioplex_WMM |
| WASHC3 | ATG13 | 0.092 | 0.356 | bioplex (WASHC3) bioplex_WMM |
| ULK1 | WASHC3 | 0.05 | 0.297 | bioplex (WASHC3) bioplex_WMM |
| ULK1 | ATG13 | 0.01 | 0.128 | bioplex_WMM WMM_only |
| ULK1 | MGAT4A | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MGAT4A | WASH3P | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MGAT4A | ATG13 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ULK1 | WASH3P | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ATG13 | WASH3P | 0.008 | 0.067 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03789 has an average edge precision of 0.279 which is ranked 4893 out of all 6965 complexes.
Related Complexes