hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03792
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SEC13 | Protein SEC13 homolog (GATOR complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | UniProt NCBI |
| WDR59 | GATOR complex protein WDR59 (WD repeat-containing protein 59) | UniProt NCBI |
| WDR24 | GATOR complex protein WDR24 (WD repeat-containing protein 24) | UniProt NCBI |
| NUP107 | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | UniProt NCBI |
| MIOS | GATOR complex protein MIOS (Missing oocyte meiosis regulator homolog) | UniProt NCBI |
| NUP37 | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6216 | 2.26981451009e-12 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | GATOR2 complex |
| CORUM:6753 | 3.17671592963e-11 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | SOG complex |
| CORUM:6217 | 3.17671592963e-11 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | GATOR complex |
| GO:0061700 | 1.80981361376e-07 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | GATOR2 complex |
| CORUM:87 | 1.89127694841e-07 | 0.5 | NUP37 NUP107 SEC13 | Nup 107-160 subcomplex |
| GO:0035859 | 8.69705349223e-07 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | Seh1-associated complex |
| KEGG:04150 | 5.73344761426e-06 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | mTOR signaling pathway |
| GO:0032008 | 1.69158658226e-05 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | positive regulation of TOR signaling |
| REAC:R-HSA-168274 | 1.94360151212e-05 | 0.5 | NUP37 NUP107 SEC13 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 1.94360151212e-05 | 0.5 | NUP37 NUP107 SEC13 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-170822 | 1.94360151212e-05 | 0.5 | NUP37 NUP107 SEC13 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 1.94360151212e-05 | 0.5 | NUP37 NUP107 SEC13 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168333 | 1.94360151212e-05 | 0.5 | NUP37 NUP107 SEC13 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-180746 | 2.40800825039e-05 | 0.5 | NUP37 NUP107 SEC13 | Nuclear import of Rev protein |
| REAC:R-HSA-159227 | 2.40800825039e-05 | 0.5 | NUP37 NUP107 SEC13 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 2.40800825039e-05 | 0.5 | NUP37 NUP107 SEC13 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-4085377 | 2.6656058306e-05 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 2.6656058306e-05 | 0.5 | NUP37 NUP107 SEC13 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-159230 | 2.6656058306e-05 | 0.5 | NUP37 NUP107 SEC13 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 2.94091318094e-05 | 0.5 | NUP37 NUP107 SEC13 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 3.23451507706e-05 | 0.5 | NUP37 NUP107 SEC13 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 3.23451507706e-05 | 0.5 | NUP37 NUP107 SEC13 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 3.54699593753e-05 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-159231 | 4.60355113742e-05 | 0.5 | NUP37 NUP107 SEC13 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-168276 | 4.60355113742e-05 | 0.5 | NUP37 NUP107 SEC13 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159234 | 4.99738490382e-05 | 0.5 | NUP37 NUP107 SEC13 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168253 | 4.99738490382e-05 | 0.5 | NUP37 NUP107 SEC13 | Host Interactions with Influenza Factors |
| REAC:R-HSA-168325 | 5.85102183028e-05 | 0.5 | NUP37 NUP107 SEC13 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4570464 | 6.79649802247e-05 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 6.79649802247e-05 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-2980766 | 8.3970836606e-05 | 0.5 | NUP37 NUP107 SEC13 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.000115897320389 | 0.5 | NUP37 NUP107 SEC13 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.000115897320389 | 0.5 | NUP37 NUP107 SEC13 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 0.000146580428081 | 0.5 | NUP37 NUP107 SEC13 | tRNA processing in the nucleus |
| GO:0031080 | 0.000217734118711 | 0.5 | NUP37 NUP107 SEC13 | nuclear pore outer ring |
| REAC:R-HSA-3371453 | 0.000257699300056 | 0.5 | NUP37 NUP107 SEC13 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-4551638 | 0.000257699300056 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-70171 | 0.000269929792646 | 0.5 | NUP37 NUP107 SEC13 | Glycolysis |
| REAC:R-HSA-1169408 | 0.00028253993633 | 0.5 | NUP37 NUP107 SEC13 | ISG15 antiviral mechanism |
| REAC:R-HSA-159236 | 0.000295535454473 | 0.5 | NUP37 NUP107 SEC13 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 0.000336891436266 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.000381921489935 | 0.5 | NUP37 NUP107 SEC13 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 0.000430779573811 | 0.5 | NUP37 NUP107 SEC13 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-5619102 | 0.0004836193603 | 0.5 | NUP37 NUP107 SEC13 | SLC transporter disorders |
| REAC:R-HSA-70326 | 0.000521133699904 | 0.5 | NUP37 NUP107 SEC13 | Glucose metabolism |
| GO:0032006 | 0.000574036481079 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | regulation of TOR signaling |
| REAC:R-HSA-3371556 | 0.00058095037578 | 0.5 | NUP37 NUP107 SEC13 | Cellular response to heat stress |
| REAC:R-HSA-141424 | 0.000737858985933 | 0.5 | NUP37 NUP107 SEC13 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.000737858985933 | 0.5 | NUP37 NUP107 SEC13 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| KEGG:03013 | 0.0009622006058 | 0.5 | NUP37 NUP107 SEC13 | RNA transport |
| REAC:R-HSA-5578749 | 0.00100731253956 | 0.5 | NUP37 NUP107 SEC13 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 0.00100731253956 | 0.5 | NUP37 NUP107 SEC13 | tRNA processing |
| GO:0031929 | 0.001058235898 | 0.666666666667 | SEC13 WDR24 WDR59 MIOS | TOR signaling |
| REAC:R-HSA-69618 | 0.00116356876711 | 0.5 | NUP37 NUP107 SEC13 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 0.00164310787995 | 0.5 | NUP37 NUP107 SEC13 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-162909 | 0.0017268331725 | 0.5 | NUP37 NUP107 SEC13 | Host Interactions of HIV factors |
| REAC:R-HSA-168273 | 0.00208996561591 | 0.5 | NUP37 NUP107 SEC13 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-211000 | 0.00218802712906 | 0.5 | NUP37 NUP107 SEC13 | Gene Silencing by RNA |
| REAC:R-HSA-68875 | 0.00218802712906 | 0.5 | NUP37 NUP107 SEC13 | Mitotic Prophase |
| REAC:R-HSA-5663220 | 0.0022381799141 | 0.5 | NUP37 NUP107 SEC13 | RHO GTPases Activate Formins |
| REAC:R-HSA-162599 | 0.0022381799141 | 0.5 | NUP37 NUP107 SEC13 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168255 | 0.00250038369951 | 0.5 | NUP37 NUP107 SEC13 | Influenza Life Cycle |
| REAC:R-HSA-162587 | 0.00296089666153 | 0.5 | NUP37 NUP107 SEC13 | HIV Life Cycle |
| REAC:R-HSA-168254 | 0.00308418008109 | 0.5 | NUP37 NUP107 SEC13 | Influenza Infection |
| REAC:R-HSA-5619115 | 0.00361124048975 | 0.5 | NUP37 NUP107 SEC13 | Disorders of transmembrane transporters |
| REAC:R-HSA-3108232 | 0.00434965166143 | 0.5 | NUP37 NUP107 SEC13 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0048372157697 | 0.5 | NUP37 NUP107 SEC13 | SUMOylation |
| REAC:R-HSA-913531 | 0.0050074145968 | 0.5 | NUP37 NUP107 SEC13 | Interferon Signaling |
| REAC:R-HSA-2467813 | 0.00582231412374 | 0.5 | NUP37 NUP107 SEC13 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.00661628360681 | 0.5 | NUP37 NUP107 SEC13 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.00661628360681 | 0.5 | NUP37 NUP107 SEC13 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00672028001895 | 0.5 | NUP37 NUP107 SEC13 | Mitotic Metaphase and Anaphase |
| CORUM:0000000 | 0.0090785708022 | 1.0 | MIOS WDR59 NUP37 WDR24 SEC13 NUP107 | CORUM root |
| GO:0006409 | 0.00986527098502 | 0.5 | NUP37 NUP107 SEC13 | tRNA export from nucleus |
| GO:0071431 | 0.00986527098502 | 0.5 | NUP37 NUP107 SEC13 | tRNA-containing ribonucleoprotein complex export from nucleus |
| REAC:R-HSA-162906 | 0.0105025954201 | 0.5 | NUP37 NUP107 SEC13 | HIV Infection |
| GO:0051031 | 0.0118307664632 | 0.5 | NUP37 NUP107 SEC13 | tRNA transport |
| REAC:R-HSA-72203 | 0.0122769600403 | 0.5 | NUP37 NUP107 SEC13 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0034198 | 0.0129043378459 | 0.5 | WDR24 WDR59 MIOS | cellular response to amino acid starvation |
| GO:0097064 | 0.0140408309691 | 0.5 | NUP37 NUP107 SEC13 | ncRNA export from nucleus |
| GO:1990928 | 0.0140408309691 | 0.5 | WDR24 WDR59 MIOS | response to amino acid starvation |
| REAC:R-HSA-71387 | 0.0169658388819 | 0.5 | NUP37 NUP107 SEC13 | Metabolism of carbohydrates |
| REAC:R-HSA-69620 | 0.0222378473272 | 0.5 | NUP37 NUP107 SEC13 | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.0276812059997 | 0.5 | NUP37 NUP107 SEC13 | RHO GTPase Effectors |
| GO:0031503 | 0.0398596812877 | 0.666666666667 | SEC13 NUP37 NUP107 MIOS | protein-containing complex localization |
| REAC:R-HSA-5663205 | 0.0427834850779 | 0.5 | NUP37 NUP107 SEC13 | Infectious disease |
| GO:0075733 | 0.0447070305646 | 0.5 | NUP37 NUP107 SEC13 | intracellular transport of virus |
| REAC:R-HSA-68886 | 0.0498388977209 | 0.5 | NUP37 NUP107 SEC13 | M Phase |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP107 | NUP37 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (NUP107) Malo fraction |
| SEC13 | NUP107 | 0.995 | 0.923 | hein_WMM bioplex (SEC13) bioplex_WMM boldt youn_WMM hein (NUP107) gupta_WMM boldt_WMM |
| SEC13 | WDR24 | 0.925 | 0.843 | hein_WMM bioplex (SEC13) bioplex_WMM boldt boldt_WMM |
| SEC13 | NUP37 | 0.831 | 0.778 | hein_WMM bioplex (SEC13) bioplex_WMM Guru fraction |
| MIOS | SEC13 | 0.816 | 0.773 | hein_WMM bioplex (SEC13) bioplex_WMM boldt boldt_WMM |
| SEC13 | WDR59 | 0.754 | 0.748 | hein_WMM bioplex (SEC13,WDR59) bioplex_WMM youn_WMM boldt_WMM |
| MIOS | WDR24 | 0.014 | 0.141 | hein_WMM bioplex_WMM boldt boldt_WMM |
| WDR24 | WDR59 | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
| MIOS | WDR59 | 0.01 | 0.098 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
| WDR24 | NUP37 | 0.007 | 0.01 | hein_WMM bioplex_WMM WMM_only |
| NUP107 | WDR24 | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| MIOS | NUP37 | 0.007 | 0.005 | hein_WMM bioplex_WMM WMM_only |
| MIOS | NUP107 | 0.007 | 0.0 | hein_WMM bioplex_WMM WMM_only |
| NUP37 | WDR59 | 0.006 | 0.006 | hein_WMM bioplex_WMM WMM_only |
| NUP107 | WDR59 | 0.006 | 0.008 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_03792 has an average edge precision of 0.362 which is ranked 3728 out of all 6965 complexes.
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