hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03795
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSP90B1 | Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog) | UniProt NCBI |
| HSPA5 | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-381183 | 6.03332446455e-05 | 1.0 | HSP90B1 HSPA5 | ATF6 (ATF6-alpha) activates chaperone genes |
| REAC:R-HSA-381033 | 9.21757904306e-05 | 1.0 | HSP90B1 HSPA5 | ATF6 (ATF6-alpha) activates chaperones |
| WP:WP3613 | 0.000121088932808 | 1.0 | HSP90B1 HSPA5 | Photodynamic therapy-induced unfolded protein response |
| CORUM:6859 | 0.000130722030065 | 1.0 | HSP90B1 HSPA5 | HRD1 complex |
| WP:WP3995 | 0.000140835743389 | 1.0 | HSP90B1 HSPA5 | Prion disease pathway |
| KEGG:04918 | 0.000332354605541 | 1.0 | HSP90B1 HSPA5 | Thyroid hormone synthesis |
| KEGG:04141 | 0.00178666132548 | 1.0 | HSP90B1 HSPA5 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-381119 | 0.00570316754246 | 1.0 | HSP90B1 HSPA5 | Unfolded Protein Response (UPR) |
| GO:0034975 | 0.020287053512 | 1.0 | HSP90B1 HSPA5 | protein folding in endoplasmic reticulum |
| GO:0036500 | 0.020287053512 | 1.0 | HSP90B1 HSPA5 | ATF6-mediated unfolded protein response |
| KEGG:03060 | 0.049938686792 | 0.5 | HSPA5 | Protein export |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSPA5 | HSP90B1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt (HSPA5) hein (HSPA5) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03795 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSP90B1 | HuMAP2_00960 HuMAP2_01492 HuMAP2_01924 HuMAP2_03097 HuMAP2_03795 |
| HSPA5 | HuMAP2_00386 HuMAP2_01492 HuMAP2_03795 |