hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03796
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CHM | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | UniProt NCBI |
| RAB31 | Ras-related protein Rab-31 (Ras-related protein Rab-22B) | UniProt NCBI |
| RAB9A | Ras-related protein Rab-9A | UniProt NCBI |
| RAB22A | Ras-related protein Rab-22A (Rab-22) | UniProt NCBI |
| TRIM4 | E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4) | UniProt NCBI |
| CHML | Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) | UniProt NCBI |
| RAB6B | Ras-related protein Rab-6B | UniProt NCBI |
| RABGGTA | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 2.15850627664e-14 | 0.875 | RABGGTA RAB6B RAB22A RAB9A CHML CHM RAB31 | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 5.26468661015e-08 | 0.625 | RAB9A CHM CHML RAB31 RAB6B | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 2.56083935255e-07 | 0.625 | RAB9A CHM CHML RAB31 RAB6B | Rab regulation of trafficking |
| GO:0005968 | 2.03382379613e-05 | 0.375 | CHM RABGGTA CHML | Rab-protein geranylgeranyltransferase complex |
| CORUM:6956 | 3.50546248845e-05 | 0.25 | CHM RABGGTA | REP-RGGT-Rab complex |
| REAC:R-HSA-597592 | 3.99090878717e-05 | 0.875 | RABGGTA RAB6B RAB22A RAB9A CHML CHM RAB31 | Post-translational protein modification |
| GO:0018344 | 0.000177825159425 | 0.375 | CHM RABGGTA CHML | protein geranylgeranylation |
| GO:0018342 | 0.000426565421795 | 0.375 | CHM RABGGTA CHML | protein prenylation |
| GO:0097354 | 0.000426565421795 | 0.375 | CHM RABGGTA CHML | prenylation |
| REAC:R-HSA-392499 | 0.000489491604102 | 0.875 | RABGGTA RAB6B RAB22A RAB9A CHML CHM RAB31 | Metabolism of proteins |
| REAC:R-HSA-199991 | 0.000799602221976 | 0.625 | RAB9A CHM CHML RAB31 RAB6B | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0010405888662 | 0.625 | RAB9A CHM CHML RAB31 RAB6B | Vesicle-mediated transport |
| GO:0032482 | 0.00163549131335 | 0.5 | RAB9A RAB6B RAB31 RAB22A | Rab protein signal transduction |
| REAC:R-HSA-6803205 | 0.00348118046261 | 0.25 | CHM RABGGTA | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-5633008 | 0.0345601208955 | 0.25 | CHM RABGGTA | TP53 Regulates Transcription of Cell Death Genes |
| GO:0004663 | 0.0378589948753 | 0.25 | CHM RABGGTA | Rab geranylgeranyltransferase activity |
| MIRNA:hsa-miR-4497 | 0.0420413406417 | 0.25 | RAB9A RAB22A | hsa-miR-4497 |
| REAC:R-HSA-6811440 | 0.047806738235 | 0.25 | RAB9A RAB6B | Retrograde transport at the Trans-Golgi-Network |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB31 | RAB22A | 1.0 | 0.949 | bioplex (RAB31) bioplex_WMM |
| CHML | RAB31 | 0.52 | 0.633 | bioplex (RAB31) bioplex_WMM |
| CHM | RAB31 | 0.401 | 0.561 | bioplex (RAB31) bioplex_WMM |
| RABGGTA | RAB31 | 0.275 | 0.487 | bioplex (RAB31) bioplex_WMM |
| RAB31 | TRIM4 | 0.193 | 0.446 | bioplex (RAB31) bioplex_WMM gupta_WMM |
| CHM | CHML | 0.099 | 0.358 | bioplex_WMM WMM_only boldt_WMM |
| CHML | RAB9A | 0.085 | 0.348 | bioplex (RAB9A) bioplex_WMM youn_WMM |
| RAB6B | CHM | 0.058 | 0.325 | bioplex (RAB6B) bioplex_WMM |
| CHML | RABGGTA | 0.052 | 0.302 | bioplex (RABGGTA) bioplex_WMM |
| RAB6B | CHML | 0.049 | 0.295 | bioplex (RAB6B) bioplex_WMM |
| CHM | RAB9A | 0.043 | 0.268 | bioplex (RAB9A) bioplex_WMM |
| CHM | RABGGTA | 0.04 | 0.268 | bioplex (RABGGTA) bioplex_WMM |
| RAB6B | RABGGTA | 0.036 | 0.264 | bioplex (RAB6B) bioplex_WMM |
| RABGGTA | RAB9A | 0.014 | 0.138 | bioplex (RAB9A) bioplex_WMM |
| RAB31 | RAB9A | 0.009 | 0.106 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| TRIM4 | RAB22A | 0.008 | 0.086 | bioplex_WMM WMM_only |
| RAB9A | RAB22A | 0.008 | 0.042 | bioplex_WMM WMM_only |
| CHML | RAB22A | 0.008 | 0.035 | bioplex_WMM WMM_only |
| RABGGTA | RAB22A | 0.008 | 0.04 | bioplex_WMM WMM_only |
| CHM | RAB22A | 0.008 | 0.041 | bioplex_WMM WMM_only |
| RAB6B | RAB22A | 0.008 | 0.024 | bioplex_WMM WMM_only |
| RAB6B | RAB31 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| RAB6B | RAB9A | 0.007 | 0.008 | bioplex_WMM WMM_only |
| CHML | TRIM4 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| RABGGTA | TRIM4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| CHM | TRIM4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| RAB9A | TRIM4 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_03796 has an average edge precision of 0.224 which is ranked 5787 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CHM | HuMAP2_01067 HuMAP2_02250 HuMAP2_03796 HuMAP2_07002 |
| RAB31 | HuMAP2_01067 HuMAP2_03796 HuMAP2_04471 HuMAP2_04752 HuMAP2_07002 |
| RAB9A | HuMAP2_01067 HuMAP2_03796 HuMAP2_07002 |
| RAB22A | HuMAP2_03796 HuMAP2_04471 HuMAP2_04752 HuMAP2_07002 |
| TRIM4 | HuMAP2_02974 HuMAP2_03796 HuMAP2_07002 |
| CHML | HuMAP2_01067 HuMAP2_03796 HuMAP2_04752 HuMAP2_07002 |
| RAB6B | HuMAP2_00116 HuMAP2_01634 HuMAP2_03796 HuMAP2_04163 |
| RABGGTA | HuMAP2_01067 HuMAP2_02113 HuMAP2_03796 HuMAP2_07002 |