hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03813
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDT1 | DNA replication factor Cdt1 (Double parked homolog) (DUP) | UniProt NCBI |
| GMNN | Geminin | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6140 | 1.67592346237e-06 | 1.0 | CDT1 GMNN | Cdt1-Geminin complex |
| CORUM:6954 | 5.02777038712e-06 | 1.0 | CDT1 GMNN | Idas-Geminin-Cdt1 complex |
| HP:0011267 | 0.00015027447046 | 1.0 | CDT1 GMNN | Microtia, third degree |
| HP:0009892 | 0.00015027447046 | 1.0 | CDT1 GMNN | Anotia |
| HP:0009939 | 0.000183668797228 | 1.0 | CDT1 GMNN | Mandibular aplasia |
| WP:WP466 | 0.000320792526609 | 1.0 | CDT1 GMNN | DNA Replication |
| HP:0006443 | 0.000350640431072 | 1.0 | CDT1 GMNN | Patellar aplasia |
| HP:0100783 | 0.000350640431072 | 1.0 | CDT1 GMNN | Breast aplasia |
| HP:0006660 | 0.000454162844056 | 1.0 | CDT1 GMNN | Aplastic clavicle |
| HP:0000064 | 0.000771408948359 | 1.0 | CDT1 GMNN | Hypoplastic labia minora |
| HP:0000039 | 0.000844876467251 | 1.0 | CDT1 GMNN | Epispadias |
| HP:0040255 | 0.000844876467251 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia of the clitoris |
| HP:0000060 | 0.000844876467251 | 1.0 | CDT1 GMNN | Clitoral hypoplasia |
| REAC:R-HSA-68962 | 0.000884887588134 | 1.0 | CDT1 GMNN | Activation of the pre-replicative complex |
| HP:0012880 | 0.00126230555186 | 1.0 | CDT1 GMNN | Abnormality of the labia minora |
| GO:0071163 | 0.00135247023414 | 1.0 | CDT1 GMNN | DNA replication preinitiation complex assembly |
| HP:0006498 | 0.00135580966681 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia of the patella |
| HP:0000059 | 0.00155283619475 | 1.0 | CDT1 GMNN | Hypoplastic labia majora |
| HP:0003100 | 0.00165635860773 | 1.0 | CDT1 GMNN | Slender long bone |
| HP:0012881 | 0.00198696244274 | 1.0 | CDT1 GMNN | Abnormality of the labia majora |
| HP:0000413 | 0.00260475748797 | 1.0 | CDT1 GMNN | Atresia of the external auditory canal |
| HP:0002097 | 0.00273833479504 | 1.0 | CDT1 GMNN | Emphysema |
| REAC:R-HSA-68827 | 0.00286750504412 | 1.0 | CDT1 GMNN | CDT1 association with the CDC6:ORC:origin complex |
| HP:0006710 | 0.00301550770722 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia of the clavicles |
| HP:0000066 | 0.00315910331233 | 1.0 | CDT1 GMNN | Labial hypoplasia |
| HP:0012815 | 0.00345631282057 | 1.0 | CDT1 GMNN | Hypoplastic female external genitalia |
| REAC:R-HSA-68867 | 0.00381775364729 | 1.0 | CDT1 GMNN | Assembly of the pre-replicative complex |
| HP:0010311 | 0.00409080502918 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia of the breasts |
| HP:0000176 | 0.00442808772954 | 1.0 | CDT1 GMNN | Submucous cleft hard palate |
| HP:0410031 | 0.00442808772954 | 1.0 | CDT1 GMNN | Submucous cleft of soft and hard palate |
| HP:0008665 | 0.00460173822874 | 1.0 | CDT1 GMNN | Clitoral hypertrophy |
| HP:0040252 | 0.00460173822874 | 1.0 | CDT1 GMNN | Abnormal size of the clitoris |
| HP:0040253 | 0.00460173822874 | 1.0 | CDT1 GMNN | Increased size of the clitoris |
| HP:0000372 | 0.00571376931014 | 1.0 | CDT1 GMNN | Abnormality of the auditory canal |
| REAC:R-HSA-69002 | 0.00598304676068 | 1.0 | CDT1 GMNN | DNA Replication Pre-Initiation |
| HP:0000058 | 0.00611116179869 | 1.0 | CDT1 GMNN | Abnormality of the labia |
| HP:0003042 | 0.00783430905996 | 1.0 | CDT1 GMNN | Elbow dislocation |
| HP:0003045 | 0.00783430905996 | 1.0 | CDT1 GMNN | Abnormal patella morphology |
| HP:0000056 | 0.00829849020205 | 1.0 | CDT1 GMNN | Abnormality of the clitoris |
| HP:0003510 | 0.00977118001255 | 1.0 | CDT1 GMNN | Severe short stature |
| HP:0030310 | 0.00977118001255 | 1.0 | CDT1 GMNN | Upper extremity joint dislocation |
| HP:0000193 | 0.0124928176442 | 1.0 | CDT1 GMNN | Bifid uvula |
| GO:0035563 | 0.0126230555186 | 1.0 | CDT1 GMNN | positive regulation of chromatin binding |
| REAC:R-HSA-69306 | 0.0131978972662 | 1.0 | CDT1 GMNN | DNA Replication |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | CDT1 GMNN | G1/S Transition |
| HP:0000889 | 0.0149105669023 | 1.0 | CDT1 GMNN | Abnormality of the clavicle |
| HP:0008551 | 0.0149105669023 | 1.0 | CDT1 GMNN | Microtia |
| HP:0000327 | 0.0161995879155 | 1.0 | CDT1 GMNN | Hypoplasia of the maxilla |
| HP:0008772 | 0.0161995879155 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia of the external ear |
| HP:0003508 | 0.0168641350182 | 1.0 | CDT1 GMNN | Proportionate short stature |
| HP:0008771 | 0.0175420398516 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia of the ear |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | CDT1 GMNN | Mitotic G1-G1/S phases |
| HP:0000172 | 0.0200198988979 | 1.0 | CDT1 GMNN | Abnormality of the uvula |
| HP:0002705 | 0.0200198988979 | 1.0 | CDT1 GMNN | High, narrow palate |
| HP:0000326 | 0.0203872364924 | 1.0 | CDT1 GMNN | Abnormality of the maxilla |
| HP:0000055 | 0.0215092858718 | 1.0 | CDT1 GMNN | Abnormality of female external genitalia |
| HP:0001363 | 0.0242442812341 | 1.0 | CDT1 GMNN | Craniosynostosis |
| GO:0035561 | 0.0247952876258 | 1.0 | CDT1 GMNN | regulation of chromatin binding |
| HP:0006711 | 0.0280011429956 | 1.0 | CDT1 GMNN | Aplasia/Hypoplasia involving bones of the thorax |
| HP:0100736 | 0.0293135400377 | 1.0 | CDT1 GMNN | Abnormal soft palate morphology |
| HP:0000189 | 0.0311101548178 | 1.0 | CDT1 GMNN | Narrow palate |
| HP:0002878 | 0.032028498804 | 1.0 | CDT1 GMNN | Respiratory failure |
| HP:0000160 | 0.0378190750657 | 1.0 | CDT1 GMNN | Narrow mouth |
| HP:0002098 | 0.0403737410635 | 1.0 | CDT1 GMNN | Respiratory distress |
| HP:0100490 | 0.0408946925611 | 1.0 | CDT1 GMNN | Camptodactyly of finger |
| HP:0001220 | 0.0419466138543 | 1.0 | CDT1 GMNN | Interphalangeal joint contracture of finger |
| HP:0006261 | 0.0457335305099 | 1.0 | CDT1 GMNN | Abnormal phalangeal joint morphology of the hand |
| HP:0005692 | 0.0462878763342 | 1.0 | CDT1 GMNN | Joint hyperflexibility |
| HP:0001328 | 0.0462878763342 | 1.0 | CDT1 GMNN | Specific learning disability |
| HP:0012785 | 0.0491096969462 | 1.0 | CDT1 GMNN | Flexion contracture of finger |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GMNN | CDT1 | 1.0 | 0.949 | hein_WMM bioplex (GMNN) bioplex_WMM hein (CDT1,GMNN) |
Images
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Complex HuMAP2_03813 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDT1 | HuMAP2_01003 HuMAP2_02530 HuMAP2_03813 |
| GMNN | HuMAP2_01003 HuMAP2_02530 HuMAP2_02598 HuMAP2_03813 |