hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03839
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WNK1 | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | UniProt NCBI |
| DENND4A | C-myc promoter-binding protein (DENN domain-containing protein 4A) | UniProt NCBI |
| LCP1 | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | UniProt NCBI |
| PLS1 | Plastin-1 (Intestine-specific plastin) (I-plastin) | UniProt NCBI |
| METTL6 | Methyltransferase-like protein 6 (EC 2.1.1.-) | UniProt NCBI |
| PLS3 | Plastin-3 (T-plastin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051639 | 6.35345863999e-05 | 0.5 | LCP1 PLS1 PLS3 | actin filament network formation |
| GO:0032432 | 0.0447070305646 | 0.5 | LCP1 PLS1 PLS3 | actin filament bundle |
| CORUM:1121 | 0.0499726005494 | 0.166666666667 | WNK1 | WNK1-OSR1 complex |
| CORUM:1123 | 0.0499726005494 | 0.166666666667 | WNK1 | WNK1-SPAK complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLS1 | PLS3 | 0.682 | 0.71 | bioplex (PLS3) bioplex_WMM youn_WMM gupta_WMM |
| METTL6 | PLS1 | 0.328 | 0.517 | bioplex (METTL6) bioplex_WMM |
| PLS1 | LCP1 | 0.201 | 0.451 | bioplex (LCP1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| WNK1 | METTL6 | 0.042 | 0.27 | bioplex (METTL6) bioplex_WMM |
| LCP1 | PLS3 | 0.039 | 0.266 | bioplex (LCP1,PLS3) bioplex_WMM youn_WMM gupta_WMM |
| DENND4A | METTL6 | 0.02 | 0.185 | bioplex (METTL6) bioplex_WMM |
| DENND4A | WNK1 | 0.008 | 0.032 | bioplex_WMM youn_WMM WMM_only |
| DENND4A | PLS1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| DENND4A | PLS3 | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| METTL6 | PLS3 | 0.007 | 0.004 | bioplex (METTL6) bioplex_WMM |
| WNK1 | LCP1 | 0.007 | 0.002 | youn_WMM gupta_WMM WMM_only |
| DENND4A | LCP1 | 0.007 | 0.001 | youn_WMM WMM_only |
| WNK1 | PLS1 | 0.007 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| WNK1 | PLS3 | 0.0 | 0.013 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_03839 has an average edge precision of 0.176 which is ranked 6468 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WNK1 | HuMAP2_00127 HuMAP2_02179 HuMAP2_02967 HuMAP2_03839 |
| DENND4A | HuMAP2_00127 HuMAP2_01947 HuMAP2_03839 HuMAP2_06465 |
| LCP1 | HuMAP2_02179 HuMAP2_02898 HuMAP2_03839 HuMAP2_04759 HuMAP2_05084 |
| PLS1 | HuMAP2_01947 HuMAP2_02179 HuMAP2_02589 HuMAP2_02898 HuMAP2_03839 HuMAP2_05084 |
| METTL6 | HuMAP2_00127 HuMAP2_01947 HuMAP2_02179 HuMAP2_02898 HuMAP2_03839 |
| PLS3 | HuMAP2_02589 HuMAP2_03839 |