hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03840
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TCEA1 | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | UniProt NCBI |
| NFATC2IP | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | UniProt NCBI |
| DLG3 | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | UniProt NCBI |
| DLG1 | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-447038 | 0.000211071833435 | 0.5 | DLG1 DLG3 | NrCAM interactions |
| REAC:R-HSA-451308 | 0.000361772624521 | 0.5 | DLG1 DLG3 | Activation of Ca-permeable Kainate Receptor |
| REAC:R-HSA-451306 | 0.000361772624521 | 0.5 | DLG1 DLG3 | Ionotropic activity of kainate receptors |
| REAC:R-HSA-442982 | 0.00153629461685 | 0.5 | DLG1 DLG3 | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 0.00171688133139 | 0.5 | DLG1 DLG3 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.00171688133139 | 0.5 | DLG1 DLG3 | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 0.0019074750117 | 0.5 | DLG1 DLG3 | Long-term potentiation |
| REAC:R-HSA-8849932 | 0.0019074750117 | 0.5 | DLG1 DLG3 | Synaptic adhesion-like molecules |
| REAC:R-HSA-442742 | 0.00326103241616 | 0.5 | DLG1 DLG3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-451326 | 0.00352159938331 | 0.5 | DLG1 DLG3 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-9609736 | 0.0070462802506 | 0.5 | DLG1 DLG3 | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04390 | 0.0198080875546 | 0.5 | DLG1 DLG3 | Hippo signaling pathway |
| KEGG:04530 | 0.0206513420529 | 0.5 | DLG1 DLG3 | Tight junction |
| REAC:R-HSA-438064 | 0.0262582706021 | 0.5 | DLG1 DLG3 | Post NMDA receptor activation events |
| REAC:R-HSA-6794362 | 0.0323499619092 | 0.5 | DLG1 DLG3 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.0347967852364 | 0.5 | DLG1 DLG3 | Activation of NMDA receptors and postsynaptic events |
| CORUM:3209 | 0.0499140284799 | 0.25 | DLG1 | LIN2-SAP97 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFATC2IP | TCEA1 | 0.927 | 0.844 | fraction |
| DLG1 | DLG3 | 0.082 | 0.351 | hein_WMM hein (DLG3) gupta_WMM |
| NFATC2IP | DLG3 | 0.0 | 0.009 | fraction |
| TCEA1 | DLG1 | 0.0 | 0.01 | fraction bioplex_WMM |
| TCEA1 | DLG3 | 0.0 | 0.002 | fraction |
Images
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Complex HuMAP2_03840 has an average edge precision of 0.243 which is ranked 5481 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TCEA1 | HuMAP2_02225 HuMAP2_03840 HuMAP2_06051 |
| NFATC2IP | HuMAP2_02225 HuMAP2_03785 HuMAP2_03840 HuMAP2_06051 |
| DLG3 | HuMAP2_03840 HuMAP2_06051 HuMAP2_06395 |
| DLG1 | HuMAP2_03001 HuMAP2_03840 HuMAP2_06395 |