hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03841

Confidence: Extremely High

Genename	Protein Name	Links
NCOR2	Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)	UniProt NCBI
GPS2	G protein pathway suppressor 2 (GPS-2)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:58	1.67592346237e-05	1.0	GPS2 NCOR2	SMRT complex
REAC:R-HSA-9022537	2.51388519356e-05	1.0	GPS2 NCOR2	Loss of MECP2 binding ability to the NCoR/SMRT complex
REAC:R-HSA-9005891	7.54165558069e-05	1.0	GPS2 NCOR2	Loss of function of MECP2 in Rett syndrome
REAC:R-HSA-9005895	7.54165558069e-05	1.0	GPS2 NCOR2	Pervasive developmental disorders
WP:WP4312	0.000352461939805	1.0	GPS2 NCOR2	Rett syndrome causing genes
REAC:R-HSA-9022692	0.000680424925724	1.0	GPS2 NCOR2	Regulation of MECP2 expression and activity
REAC:R-HSA-8986944	0.00230942253115	1.0	GPS2 NCOR2	Transcriptional Regulation by MECP2
REAC:R-HSA-3214815	0.00716960057204	1.0	GPS2 NCOR2	HDACs deacetylate histones
REAC:R-HSA-1989781	0.00932651406811	1.0	GPS2 NCOR2	PPARA activates gene expression
REAC:R-HSA-400206	0.00950416195513	1.0	GPS2 NCOR2	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Protein 1	Protein 2	Score	Precision	Evidence
NCOR2	GPS2	1.0	0.949	bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM

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ComplexPrecisionDistribution

Complex HuMAP2_03841 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NCOR2	HuMAP2_00648 HuMAP2_03841 HuMAP2_05428 HuMAP2_05452
GPS2	HuMAP2_02514 HuMAP2_03841 HuMAP2_05428 HuMAP2_05452