hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03854
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WDR45B | WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) | UniProt NCBI |
| CCND1 | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | UniProt NCBI |
| CDKN2C | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | UniProt NCBI |
| UBE2A | Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) | UniProt NCBI |
| FAM114A1 | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | UniProt NCBI |
| PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | UniProt NCBI |
| GAS2L1 | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | UniProt NCBI |
| MAPRE3 | Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2261 | 0.000446878785088 | 0.375 | CDKN2C PLCG1 CCND1 | Signaling Pathways in Glioblastoma |
| WP:WP3998 | 0.0119507998541 | 0.25 | CDKN2C CCND1 | Prader-Willi and Angelman Syndrome |
| KEGG:05223 | 0.0240649309102 | 0.25 | CCND1 PLCG1 | Non-small cell lung cancer |
| WP:WP45 | 0.0245464965472 | 0.25 | CDKN2C CCND1 | G1 to S cell cycle control |
| KEGG:05214 | 0.0271631823103 | 0.25 | CCND1 PLCG1 | Glioma |
| WP:WP4255 | 0.0302961097702 | 0.25 | CCND1 PLCG1 | Non-small cell lung cancer |
| WP:WP2034 | 0.0338475396753 | 0.25 | CCND1 PLCG1 | Leptin signaling pathway |
| REAC:R-HSA-69231 | 0.0381285523959 | 0.25 | CDKN2C CCND1 | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 0.0381285523959 | 0.25 | CDKN2C CCND1 | G1 Phase |
| WP:WP673 | 0.0446052271652 | 0.25 | CCND1 PLCG1 | ErbB Signaling Pathway |
| KEGG:01522 | 0.0474744022862 | 0.25 | CDKN2C CCND1 | Endocrine resistance |
| KEGG:04933 | 0.0485281855609 | 0.25 | CCND1 PLCG1 | AGE-RAGE signaling pathway in diabetic complications |
| CORUM:3087 | 0.0497224828424 | 0.125 | CCND1 | CCND1-CDK6 complex |
| CORUM:2956 | 0.0497224828424 | 0.125 | PLCG1 | PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated |
| CORUM:2635 | 0.0497224828424 | 0.125 | CCND1 | BETA2-Cyclin D1 complex |
| CORUM:5287 | 0.0497224828424 | 0.125 | CCND1 | CCND1-CDK4 complex |
| CORUM:3084 | 0.0497224828424 | 0.125 | CCND1 | CCND1-CDK4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPRE3 | GAS2L1 | 1.0 | 0.949 | bioplex (GAS2L1) bioplex_WMM |
| WDR45B | GAS2L1 | 0.047 | 0.293 | bioplex (GAS2L1) bioplex_WMM |
| PLCG1 | GAS2L1 | 0.041 | 0.27 | bioplex (GAS2L1) bioplex_WMM |
| CDKN2C | CCND1 | 0.035 | 0.261 | bioplex (CCND1) bioplex_WMM |
| CDKN2C | GAS2L1 | 0.031 | 0.24 | bioplex (GAS2L1) bioplex_WMM |
| UBE2A | PLCG1 | 0.029 | 0.233 | fraction |
| FAM114A1 | MAPRE3 | 0.029 | 0.233 | fraction |
| CDKN2C | MAPRE3 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| PLCG1 | MAPRE3 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CDKN2C | PLCG1 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| UBE2A | WDR45B | 0.007 | 0.004 | bioplex_WMM WMM_only |
| WDR45B | MAPRE3 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PLCG1 | WDR45B | 0.007 | 0.007 | bioplex_WMM WMM_only |
| CDKN2C | WDR45B | 0.006 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03854 has an average edge precision of 0.179 which is ranked 6432 out of all 6965 complexes.
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