hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03857
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WIPF2 | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | UniProt NCBI |
| WIPF1 | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | UniProt NCBI |
| WIPF3 | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | UniProt NCBI |
| WASL | Neural Wiskott-Aldrich syndrome protein (N-WASP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044396 | 3.6593342028e-10 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin cortical patch organization |
| GO:0000147 | 3.6593342028e-10 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin cortical patch assembly |
| GO:0051666 | 8.5384464732e-10 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin cortical patch localization |
| REAC:R-HSA-5663213 | 4.74851893082e-09 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-2029482 | 4.12752946315e-08 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Regulation of actin dynamics for phagocytic cup formation |
| GO:0030479 | 4.43999216606e-08 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin cortical patch |
| GO:0061645 | 4.43999216606e-08 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | endocytic patch |
| KEGG:05135 | 1.12234400264e-07 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Yersinia infection |
| REAC:R-HSA-2029480 | 1.43433204175e-07 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0030866 | 5.79418977671e-07 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cortical actin cytoskeleton organization |
| KEGG:05130 | 7.1423156032e-07 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Pathogenic Escherichia coli infection |
| GO:0030865 | 9.98266370523e-07 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cortical cytoskeleton organization |
| KEGG:04144 | 2.0886994429e-06 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Endocytosis |
| GO:0030864 | 2.10899871844e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cortical actin cytoskeleton |
| GO:0038094 | 2.96515850453e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Fc-gamma receptor signaling pathway |
| GO:0038096 | 2.96515850453e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0002433 | 2.96515850453e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0002431 | 3.30139032886e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Fc receptor mediated stimulatory signaling pathway |
| REAC:R-HSA-195258 | 3.37844063501e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | RHO GTPase Effectors |
| GO:0030863 | 4.70712600242e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cortical cytoskeleton |
| GO:0005884 | 8.45267167948e-05 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin filament |
| GO:0030048 | 0.000116616394242 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin filament-based movement |
| REAC:R-HSA-194315 | 0.000127392742142 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Signaling by Rho GTPases |
| GO:0044448 | 0.000342608092204 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cell cortex part |
| GO:0051015 | 0.000396049862747 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin filament binding |
| GO:0038093 | 0.000674462133054 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Fc receptor signaling pathway |
| GO:0006909 | 0.00131070874123 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | phagocytosis |
| GO:0005938 | 0.00151538042626 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cell cortex |
| REAC:R-HSA-168249 | 0.00243001134371 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Innate Immune System |
| GO:0003779 | 0.00482615258054 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin binding |
| GO:0002429 | 0.00629241325149 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | immune response-activating cell surface receptor signaling pathway |
| MIRNA:hsa-miR-99a-3p | 0.00771516028001 | 0.5 | WIPF1 WIPF2 | hsa-miR-99a-3p |
| GO:0099568 | 0.00785572034373 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | cytoplasmic region |
| GO:0002768 | 0.008399180142 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | immune response-regulating cell surface receptor signaling pathway |
| GO:0006897 | 0.0135035907885 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | endocytosis |
| MIRNA:hsa-miR-99b-3p | 0.0196380022518 | 0.5 | WIPF1 WIPF2 | hsa-miR-99b-3p |
| GO:0099513 | 0.0217579468269 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | polymeric cytoskeletal fiber |
| GO:0015629 | 0.0224486277146 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | actin cytoskeleton |
| CORUM:2513 | 0.0249595281251 | 0.25 | WASL | N-WASp homomer complex |
| GO:0002757 | 0.0285830601899 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | immune response-activating signal transduction |
| GO:0002764 | 0.0352384618295 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | immune response-regulating signaling pathway |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | Immune System |
| GO:0098657 | 0.0403998712414 | 1.0 | WASL WIPF3 WIPF1 WIPF2 | import into cell |
| CORUM:2297 | 0.0499140284799 | 0.25 | WASL | ABI1-WASL complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WIPF1 | WASL | 0.995 | 0.924 | hein_WMM bioplex (WASL) bioplex_WMM |
| WIPF3 | WASL | 0.968 | 0.88 | bioplex (WASL) bioplex_WMM |
| WIPF2 | WASL | 0.833 | 0.78 | hein_WMM bioplex (WASL) bioplex_WMM |
| WIPF1 | WIPF2 | 0.017 | 0.166 | hein_WMM bioplex_WMM WMM_only |
| WIPF1 | WIPF3 | 0.014 | 0.141 | bioplex_WMM WMM_only |
| WIPF2 | WIPF3 | 0.014 | 0.141 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03857 has an average edge precision of 0.505 which is ranked 2470 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WIPF2 | HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_04864 HuMAP2_05979 |
| WIPF1 | HuMAP2_00621 HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_05979 |
| WIPF3 | HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_04864 HuMAP2_05979 |
| WASL | HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_04864 HuMAP2_05979 |