hu.MAP 2.0: Complex View

Genename	Protein Name	Links
ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)	UniProt NCBI
DBI	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)	UniProt NCBI
FH	Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2)	UniProt NCBI
ACO2	Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)	UniProt NCBI
PGM1	Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)	UniProt NCBI
ETFA	Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)	UniProt NCBI
MSRA	Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP78	0.00136514339455	0.285714285714	FH ACO2	TCA Cycle (aka Krebs or citric acid cycle)
WP:WP4595	0.00210605462929	0.285714285714	FH ALDH4A1	Urea cycle and associated pathways
KEGG:00020	0.00400477105594	0.285714285714	FH ACO2	Citrate cycle (TCA cycle)
REAC:R-HSA-1430728	0.00415508232387	0.857142857143	FH ETFA PGM1 DBI ALDH4A1 ACO2	Metabolism
GO:0044281	0.00456795183371	1.0	FH ETFA MSRA PGM1 DBI ALDH4A1 ACO2	small molecule metabolic process
REAC:R-HSA-71403	0.00662104130949	0.285714285714	FH ACO2	Citric acid cycle (TCA cycle)
REAC:R-HSA-1428517	0.0075633471129	0.428571428571	FH ACO2 ETFA	The citric acid (TCA) cycle and respiratory electron transport
WP:WP4290	0.00859430044807	0.285714285714	FH ACO2	Metabolic reprogramming in colon cancer
GO:0019752	0.00899876078428	0.857142857143	FH ETFA MSRA PGM1 ALDH4A1 ACO2	carboxylic acid metabolic process
HP:0003355	0.0103685612154	0.428571428571	FH ALDH4A1 ETFA	Aminoaciduria
GO:0043436	0.0147858371095	0.857142857143	FH ETFA MSRA PGM1 ALDH4A1 ACO2	oxoacid metabolic process
GO:0006082	0.016122709633	0.857142857143	FH ETFA MSRA PGM1 ALDH4A1 ACO2	organic acid metabolic process
HP:0012072	0.029622117541	0.428571428571	FH ALDH4A1 ETFA	Aciduria
WP:WP3925	0.0378182063894	0.285714285714	FH ACO2	Amino Acid metabolism
REAC:R-HSA-71406	0.0415178062253	0.285714285714	FH ACO2	Pyruvate metabolism and Citric Acid (TCA) cycle

Protein 1	Protein 2	Score	Precision	Evidence
ACO2	ALDH4A1	0.927	0.844	Guru fraction
MSRA	ALDH4A1	0.863	0.8	fraction
MSRA	ACO2	0.856	0.793	fraction
ALDH4A1	ETFA	0.827	0.774	fraction
PGM1	ACO2	0.823	0.774	bioplex_WMM fraction
ACO2	ETFA	0.81	0.771	bioplex (ETFA) bioplex_WMM Guru fraction
PGM1	ALDH4A1	0.762	0.749	fraction treiber_WMM
DBI	ALDH4A1	0.76	0.75	fraction
ALDH4A1	FH	0.738	0.738	Guru fraction
MSRA	DBI	0.701	0.723	fraction
ACO2	FH	0.163	0.42	bioplex_WMM Guru fraction
MSRA	PGM1	0.039	0.264	fraction
MSRA	FH	0.02	0.187	fraction
DBI	ACO2	0.014	0.137	bioplex_WMM Guru fraction
PGM1	ETFA	0.014	0.143	bioplex (ETFA) bioplex_WMM fraction treiber_WMM
FH	ETFA	0.0	0.011	bioplex (ETFA) bioplex_WMM fraction treiber_WMM
DBI	PGM1	0.0	0.008	bioplex_WMM fraction
MSRA	ETFA	0.0	0.0	fraction
PGM1	FH	0.0	0.001	bioplex_WMM fraction
DBI	ETFA	0.0	0.001	bioplex (ETFA) bioplex_WMM fraction
DBI	FH	0.0	0.001	bioplex_WMM Guru fraction

Click to enlarge

Complex HuMAP2_03864 has an average edge precision of 0.423 which is ranked 3084 out of all 6965 complexes.

Genename	Complexes
ALDH4A1	HuMAP2_01072 HuMAP2_01176 HuMAP2_01792 HuMAP2_02582 HuMAP2_03357 HuMAP2_03864 HuMAP2_04246 HuMAP2_06021 HuMAP2_06543
DBI	HuMAP2_00126 HuMAP2_01792 HuMAP2_03864 HuMAP2_04246 HuMAP2_06021
FH	HuMAP2_01290 HuMAP2_02379 HuMAP2_02582 HuMAP2_03864
ACO2	HuMAP2_00781 HuMAP2_00787 HuMAP2_03864 HuMAP2_04579
PGM1	HuMAP2_00781 HuMAP2_00787 HuMAP2_02582 HuMAP2_03864 HuMAP2_04246 HuMAP2_06788
ETFA	HuMAP2_01755 HuMAP2_02394 HuMAP2_02404 HuMAP2_02485 HuMAP2_03040 HuMAP2_03864 HuMAP2_05635
MSRA	HuMAP2_00027 HuMAP2_00781 HuMAP2_01072 HuMAP2_01792 HuMAP2_02082 HuMAP2_03357 HuMAP2_03864 HuMAP2_04246 HuMAP2_06261