hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03879
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HLA-DRA | HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA) | UniProt NCBI |
| HLA-DRB1 | HLA class II histocompatibility antigen, DRB1-3 chain (Clone P2-beta-3) (MHC class II antigen DRB1*3) | UniProt NCBI |
| HLA-DRB5 | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05310 | 8.60069958365e-09 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Asthma |
| KEGG:05330 | 3.99962603016e-08 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Allograft rejection |
| KEGG:05332 | 6.91664651832e-08 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Graft-versus-host disease |
| KEGG:04672 | 7.81881780332e-08 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Intestinal immune network for IgA production |
| REAC:R-HSA-202430 | 9.89113204212e-08 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Translocation of ZAP-70 to Immunological synapse |
| KEGG:04940 | 1.09884462513e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Type I diabetes mellitus |
| KEGG:05320 | 1.9682370201e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Autoimmune thyroid disease |
| REAC:R-HSA-202427 | 2.04566594508e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Phosphorylation of CD3 and TCR zeta chains |
| REAC:R-HSA-389948 | 3.05725899484e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | PD-1 signaling |
| KEGG:05321 | 3.9827854995e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Inflammatory bowel disease (IBD) |
| KEGG:05416 | 4.56498670209e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Viral myocarditis |
| KEGG:04640 | 7.04475484079e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Hematopoietic cell lineage |
| KEGG:04612 | 7.45915218436e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Antigen processing and presentation |
| KEGG:05323 | 8.33606267338e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Rheumatoid arthritis |
| KEGG:05140 | 8.79917726635e-07 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Leishmaniasis |
| REAC:R-HSA-202433 | 1.03407289531e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Generation of second messenger molecules |
| KEGG:05150 | 1.37611193338e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Staphylococcus aureus infection |
| KEGG:04658 | 1.7187866598e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Th1 and Th2 cell differentiation |
| WP:WP2328 | 1.98744537714e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Allograft Rejection |
| KEGG:04659 | 3.07760697689e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Th17 cell differentiation |
| KEGG:05145 | 4.03102159088e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Toxoplasmosis |
| KEGG:04514 | 5.01156148816e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Cell adhesion molecules (CAMs) |
| KEGG:05322 | 7.04102586614e-06 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Systemic lupus erythematosus |
| GO:0042613 | 1.08982291228e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | MHC class II protein complex |
| REAC:R-HSA-388841 | 1.11518017806e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Costimulation by the CD28 family |
| KEGG:04145 | 1.20588724809e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Phagosome |
| KEGG:05164 | 1.59201956531e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Influenza A |
| KEGG:05152 | 1.65789009806e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Tuberculosis |
| WP:WP4217 | 1.71921496722e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Ebola Virus Pathway on Host |
| KEGG:05169 | 3.02146485782e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Epstein-Barr virus infection |
| REAC:R-HSA-877300 | 3.03590314156e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Interferon gamma signaling |
| KEGG:05166 | 3.77375241277e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Human T-cell leukemia virus 1 infection |
| WP:WP530 | 4.31484851616e-05 | 0.666666666667 | HLA-DRA HLA-DRB1 | Cytokines and Inflammatory Response |
| GO:0042611 | 5.08584025729e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | MHC protein complex |
| REAC:R-HSA-202424 | 5.10580236014e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Downstream TCR signaling |
| GO:0042605 | 8.80032001664e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | peptide antigen binding |
| REAC:R-HSA-202403 | 8.92382428809e-05 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | TCR signaling |
| REAC:R-HSA-2132295 | 0.000113954833063 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | MHC class II antigen presentation |
| GO:0098553 | 0.000160839698137 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | lumenal side of endoplasmic reticulum membrane |
| GO:0071556 | 0.000160839698137 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | integral component of lumenal side of endoplasmic reticulum membrane |
| GO:0098576 | 0.000265644334868 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | lumenal side of membrane |
| KEGG:05168 | 0.0002707003734 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Herpes simplex virus 1 infection |
| GO:0030669 | 0.000331851076788 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | clathrin-coated endocytic vesicle membrane |
| REAC:R-HSA-913531 | 0.000387967964833 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Interferon Signaling |
| GO:0003823 | 0.000543458358922 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | antigen binding |
| GO:0045334 | 0.00104259725275 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | clathrin-coated endocytic vesicle |
| GO:0012507 | 0.00128871559377 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | ER to Golgi transport vesicle membrane |
| GO:0031902 | 0.00238262534197 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | late endosome membrane |
| GO:0060333 | 0.00541641987402 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | interferon-gamma-mediated signaling pathway |
| GO:0030134 | 0.00564855215433 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | COPII-coated ER to Golgi transport vesicle |
| GO:0030665 | 0.00638454589443 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | clathrin-coated vesicle membrane |
| GO:0032588 | 0.00804289309261 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | trans-Golgi network membrane |
| GO:0030660 | 0.00929437307021 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Golgi-associated vesicle membrane |
| GO:0019886 | 0.0103137207675 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 0.0106693663112 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 0.0110330947082 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| GO:0071346 | 0.0170248502613 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | cellular response to interferon-gamma |
| GO:0030658 | 0.0175207196864 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | transport vesicle membrane |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Adaptive Immune System |
| GO:0030666 | 0.0212638981157 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | endocytic vesicle membrane |
| GO:0034341 | 0.0230188762788 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | response to interferon-gamma |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Cytokine Signaling in Immune system |
| GO:0032395 | 0.0283955176165 | 0.666666666667 | HLA-DRA HLA-DRB1 | MHC class II receptor activity |
| GO:0030176 | 0.0310032822085 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | integral component of endoplasmic reticulum membrane |
| GO:0030136 | 0.0310032822085 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | clathrin-coated vesicle |
| GO:0030662 | 0.033252767518 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | coated vesicle membrane |
| GO:0031227 | 0.0356085105614 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | intrinsic component of endoplasmic reticulum membrane |
| GO:0005798 | 0.0372392489125 | 1.0 | HLA-DRB5 HLA-DRA HLA-DRB1 | Golgi-associated vesicle |
| GO:0030247 | 0.0378589948753 | 0.666666666667 | HLA-DRA HLA-DRB1 | polysaccharide binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HLA-DRB1 | 100294276 | 0.97 | 0.881 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRB1 | HLA-DRB5 | 0.954 | 0.861 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRA | HLA-DRB5 | 0.058 | 0.325 | bioplex (HLA-DRA) bioplex_WMM |
| HLA-DRB5 | 100294276 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| HLA-DRA | HLA-DRB1 | 0.006 | 0.007 | bioplex (HLA-DRA) bioplex_WMM |
| HLA-DRA | 100294276 | 0.003 | 0.012 | bioplex (HLA-DRA) bioplex_WMM |
Images
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Complex HuMAP2_03879 has an average edge precision of 0.364 which is ranked 3709 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HLA-DRA | HuMAP2_00757 HuMAP2_03879 HuMAP2_06394 |
| HLA-DRB1 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |
| HLA-DRB5 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |