hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03884
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha (G(i) alpha-3) | UniProt NCBI |
| GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04730 | 7.04475484079e-07 | 1.0 | GNAI2 GNAO1 GNAI3 | Long-term depression |
| REAC:R-HSA-202040 | 1.16895196861e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | G-protein activation |
| KEGG:04727 | 2.37809343488e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | GABAergic synapse |
| KEGG:05032 | 2.56577513453e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Morphine addiction |
| WP:WP2032 | 2.81344354659e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| KEGG:04713 | 3.30002227102e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Circadian entrainment |
| KEGG:05142 | 3.30002227102e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Chagas disease (American trypanosomiasis) |
| KEGG:04916 | 3.41513932698e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Melanogenesis |
| KEGG:05145 | 4.03102159088e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Toxoplasmosis |
| REAC:R-HSA-6814122 | 4.10886616968e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| KEGG:04726 | 4.1624679471e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Serotonergic synapse |
| KEGG:04725 | 4.29674110668e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Cholinergic synapse |
| KEGG:04724 | 4.86270322614e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Glutamatergic synapse |
| WP:WP35 | 6.82717373445e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | G Protein Signaling Pathways |
| KEGG:04926 | 8.44552612263e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Relaxin signaling pathway |
| KEGG:04728 | 8.66024288846e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Dopaminergic synapse |
| KEGG:04915 | 8.87856833943e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | Estrogen signaling pathway |
| REAC:R-HSA-112043 | 9.36285567169e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | PLC beta mediated events |
| REAC:R-HSA-112040 | 9.93609173322e-06 | 1.0 | GNAI2 GNAO1 GNAI3 | G-protein mediated events |
| KEGG:04723 | 1.12669164546e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Retrograde endocannabinoid signaling |
| KEGG:04921 | 1.20588724809e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Oxytocin signaling pathway |
| WP:WP536 | 1.8088999213e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Calcium Regulation in the Cardiac Cell |
| KEGG:05034 | 2.25139851409e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Alcoholism |
| KEGG:04015 | 2.55027583186e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Rap1 signaling pathway |
| KEGG:05170 | 3.89046029743e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 4.06999539039e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Human cytomegalovirus infection |
| REAC:R-HSA-111885 | 4.60117478723e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Opioid Signalling |
| GO:0031683 | 5.08584025729e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | G-protein beta/gamma-subunit complex binding |
| REAC:R-HSA-390466 | 5.28186451049e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 6.42384066445e-05 | 1.0 | GNAI2 GNAO1 GNAI3 | Protein folding |
| GO:0005834 | 0.00023612829766 | 1.0 | GNAI2 GNAO1 GNAI3 | heterotrimeric G-protein complex |
| GO:1905360 | 0.00023612829766 | 1.0 | GNAI2 GNAO1 GNAI3 | GTPase complex |
| WP:WP26 | 0.000287463336731 | 0.666666666667 | GNAI2 GNAI3 | Signal Transduction of S1P Receptor |
| KEGG:04923 | 0.000422858026176 | 0.666666666667 | GNAI2 GNAI3 | Regulation of lipolysis in adipocytes |
| KEGG:05030 | 0.000462599152438 | 0.666666666667 | GNAI2 GNAI3 | Cocaine addiction |
| REAC:R-HSA-170670 | 0.00060895383853 | 0.666666666667 | GNAI2 GNAI3 | Adenylate cyclase inhibitory pathway |
| KEGG:04924 | 0.000615711573085 | 0.666666666667 | GNAI2 GNAI3 | Renin secretion |
| KEGG:05133 | 0.00079061479837 | 0.666666666667 | GNAI2 GNAI3 | Pertussis |
| KEGG:04971 | 0.000817378611711 | 0.666666666667 | GNAI2 GNAI3 | Gastric acid secretion |
| REAC:R-HSA-392170 | 0.00127110038679 | 0.666666666667 | GNAI2 GNAI3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-418594 | 0.00131699973544 | 1.0 | GNAI2 GNAO1 GNAI3 | G alpha (i) signalling events |
| KEGG:04914 | 0.00144586300556 | 0.666666666667 | GNAI2 GNAI3 | Progesterone-mediated oocyte maturation |
| KEGG:04540 | 0.00155543182841 | 0.666666666667 | GNAI2 GNAI3 | Gap junction |
| KEGG:04670 | 0.0017077231529 | 0.666666666667 | GNAI2 GNAI3 | Leukocyte transendothelial migration |
| KEGG:04928 | 0.00207626517498 | 0.666666666667 | GNAI2 GNAI3 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04071 | 0.00262334701465 | 0.666666666667 | GNAI2 GNAI3 | Sphingolipid signaling pathway |
| REAC:R-HSA-392518 | 0.00271504560844 | 0.666666666667 | GNAI2 GNAI3 | Signal amplification |
| KEGG:04611 | 0.00272070891872 | 0.666666666667 | GNAI2 GNAI3 | Platelet activation |
| WP:WP2806 | 0.00302048413579 | 0.666666666667 | GNAI2 GNAI3 | Human Complement System |
| REAC:R-HSA-977444 | 0.0033164570092 | 0.666666666667 | GNAI2 GNAI3 | GABA B receptor activation |
| REAC:R-HSA-991365 | 0.0033164570092 | 0.666666666667 | GNAI2 GNAI3 | Activation of GABAB receptors |
| WP:WP2355 | 0.00333149228497 | 0.666666666667 | GNAI2 GNAO1 | Corticotropin-releasing hormone signaling pathway |
| KEGG:04371 | 0.00339655892893 | 0.666666666667 | GNAI2 GNAI3 | Apelin signaling pathway |
| KEGG:05012 | 0.00350714576187 | 0.666666666667 | GNAI2 GNAI3 | Parkinson disease |
| WP:WP4540 | 0.00357470816736 | 0.666666666667 | GNAI2 GNAI3 | Pathways Regulating Hippo Signaling |
| KEGG:04261 | 0.00367632825889 | 0.666666666667 | GNAI2 GNAI3 | Adrenergic signaling in cardiomyocytes |
| KEGG:04062 | 0.00373360278335 | 0.666666666667 | GNAI2 GNAI3 | Chemokine signaling pathway |
| KEGG:04934 | 0.00439265454468 | 0.666666666667 | GNAI2 GNAI3 | Cushing syndrome |
| KEGG:04022 | 0.00439265454468 | 0.666666666667 | GNAI2 GNAI3 | cGMP-PKG signaling pathway |
| KEGG:04360 | 0.00601503157228 | 0.666666666667 | GNAI2 GNAI3 | Axon guidance |
| REAC:R-HSA-418597 | 0.00632193682699 | 0.666666666667 | GNAI2 GNAI3 | G alpha (z) signalling events |
| KEGG:04024 | 0.0063848075241 | 0.666666666667 | GNAI2 GNAI3 | cAMP signaling pathway |
| GO:0031234 | 0.00664337883609 | 1.0 | GNAI2 GNAO1 GNAI3 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-977443 | 0.00691608633843 | 0.666666666667 | GNAI2 GNAI3 | GABA receptor activation |
| WP:WP3929 | 0.00727489926623 | 0.666666666667 | GNAI2 GNAI3 | Chemokine signaling pathway |
| REAC:R-HSA-388396 | 0.0116036179019 | 1.0 | GNAI2 GNAO1 GNAI3 | GPCR downstream signalling |
| REAC:R-HSA-9009391 | 0.0143204798819 | 0.666666666667 | GNAI2 GNAI3 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-372790 | 0.0148482904699 | 1.0 | GNAI2 GNAO1 GNAI3 | Signaling by GPCR |
| GO:0007188 | 0.0206993698472 | 1.0 | GNAI2 GNAO1 GNAI3 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| GO:0019897 | 0.0281650200706 | 1.0 | GNAI2 GNAO1 GNAI3 | extrinsic component of plasma membrane |
| GO:0007187 | 0.0302766427817 | 1.0 | GNAI2 GNAO1 GNAI3 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO:0009898 | 0.0310032822085 | 1.0 | GNAI2 GNAO1 GNAI3 | cytoplasmic side of plasma membrane |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | GNAI2 GNAI3 | Pathways in cancer |
| GO:0098562 | 0.0480789908723 | 1.0 | GNAI2 GNAO1 GNAI3 | cytoplasmic side of membrane |
| GO:0001664 | 0.0490669153423 | 1.0 | GNAI2 GNAO1 GNAI3 | G protein-coupled receptor binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAI2 | GNAI3 | 1.0 | 0.949 | hein_WMM bioplex (GNAI3) bioplex_WMM youn_WMM |
| GNAI3 | GNAO1 | 0.978 | 0.894 | bioplex (GNAI3) bioplex_WMM |
| GNAI2 | GNAO1 | 0.602 | 0.671 | bioplex (GNAI2) bioplex_WMM |
Images
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Complex HuMAP2_03884 has an average edge precision of 0.838 which is ranked 821 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNAI2 | HuMAP2_01804 HuMAP2_03884 HuMAP2_04804 HuMAP2_05902 |
| GNAI3 | HuMAP2_01804 HuMAP2_02804 HuMAP2_03884 HuMAP2_04026 HuMAP2_04804 HuMAP2_05902 |
| GNAO1 | HuMAP2_01804 HuMAP2_03884 HuMAP2_05902 |