hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03890

Confidence: Medium

Genename	Protein Name	Links
KLHL42	Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)	UniProt NCBI
KCTD20	BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20)	UniProt NCBI
KLHL24	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	UniProt NCBI
KLHL8	Kelch-like protein 8	UniProt NCBI
BTBD10	BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1)	UniProt NCBI
ANKRD39	Ankyrin repeat domain-containing protein 39	UniProt NCBI
CUL3	Cullin-3 (CUL-3)	UniProt NCBI
ARMC5	Armadillo repeat-containing protein 5	UniProt NCBI
KLHL23	Kelch-like protein 23	UniProt NCBI
LRRC42	Leucine-rich repeat-containing protein 42	UniProt NCBI
KCTD6	BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)	UniProt NCBI
KBTBD6	Kelch repeat and BTB domain-containing protein 6	UniProt NCBI
KLHL11	Kelch-like protein 11	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7371	4.02797549685e-05	0.153846153846	CUL3 KCTD6	CUL3-KCTD6 complex
CORUM:7518	4.02797549685e-05	0.153846153846	KLHL8 CUL3	Ubiquitin E3 ligase (CUL3, KLHL8)
CORUM:7533	4.02797549685e-05	0.153846153846	KLHL42 CUL3	Ubiquitin E3 ligase (CUL3, KLHL42)
CORUM:7525	0.000120779759493	0.153846153846	KLHL24 CUL3	Ubiquitin E3 ligase (CUL3, KLHL24, RBX1)
REAC:R-HSA-8951664	0.000196468982105	0.384615384615	KCTD6 KLHL42 KLHL11 KBTBD6 CUL3	Neddylation
REAC:R-HSA-983168	0.000757565872969	0.384615384615	KCTD6 KLHL42 KLHL11 KBTBD6 CUL3	Antigen processing: Ubiquitination & Proteasome degradation
GO:0031463	0.00113375994827	0.307692307692	CUL3 KLHL24 KLHL42 KLHL8	Cul3-RING ubiquitin ligase complex
REAC:R-HSA-983169	0.00181067972611	0.384615384615	KCTD6 KLHL42 KLHL11 KBTBD6 CUL3	Class I MHC mediated antigen processing & presentation
REAC:R-HSA-1280218	0.0353116362159	0.384615384615	KCTD6 KLHL42 KLHL11 KBTBD6 CUL3	Adaptive Immune System
MIRNA:hsa-miR-340-5p	0.0433590570955	0.307692307692	KCTD6 BTBD10 KCTD20 KLHL42	hsa-miR-340-5p

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CUL3	KLHL42	0.979	0.896	hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3)
KBTBD6	CUL3	0.804	0.768	hein_WMM bioplex (CUL3) bioplex_WMM boldt youn_WMM hein (CUL3) boldt_WMM
CUL3	KLHL8	0.591	0.664	hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3)
CUL3	KCTD20	0.571	0.655	hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3)
CUL3	ANKRD39	0.387	0.551	bioplex (CUL3) bioplex_WMM
CUL3	KLHL24	0.265	0.481	hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3)
CUL3	BTBD10	0.227	0.468	hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3)
CUL3	KLHL23	0.112	0.38	bioplex (CUL3) bioplex_WMM
CUL3	ARMC5	0.088	0.355	bioplex (CUL3) bioplex_WMM
CUL3	LRRC42	0.038	0.262	bioplex (CUL3,LRRC42) bioplex_WMM
CUL3	KCTD6	0.037	0.267	bioplex (CUL3) bioplex_WMM
CUL3	KLHL11	0.022	0.198	bioplex (CUL3) bioplex_WMM
KCTD20	BTBD10	0.014	0.137	hein_WMM bioplex_WMM WMM_only
KCTD20	KLHL24	0.008	0.094	hein_WMM bioplex_WMM WMM_only
BTBD10	KLHL24	0.008	0.095	hein_WMM bioplex_WMM WMM_only
KLHL42	KLHL24	0.008	0.091	hein_WMM bioplex_WMM WMM_only
BTBD10	ANKRD39	0.008	0.091	bioplex_WMM WMM_only
ANKRD39	ARMC5	0.008	0.087	bioplex_WMM WMM_only
LRRC42	ANKRD39	0.008	0.087	bioplex_WMM WMM_only
KCTD20	ANKRD39	0.008	0.087	bioplex_WMM WMM_only
KCTD20	KLHL42	0.008	0.083	hein_WMM bioplex_WMM WMM_only
KLHL23	ARMC5	0.008	0.083	bioplex_WMM WMM_only
KLHL42	BTBD10	0.008	0.083	hein_WMM bioplex_WMM WMM_only
KCTD20	KLHL8	0.008	0.082	hein_WMM bioplex_WMM WMM_only
KLHL8	BTBD10	0.008	0.071	hein_WMM bioplex_WMM WMM_only
BTBD10	ARMC5	0.008	0.067	bioplex_WMM WMM_only
LRRC42	BTBD10	0.008	0.067	bioplex_WMM WMM_only
ANKRD39	KLHL11	0.008	0.066	bioplex_WMM WMM_only
KCTD6	ANKRD39	0.008	0.066	bioplex_WMM WMM_only
KCTD20	LRRC42	0.008	0.06	bioplex_WMM WMM_only
LRRC42	ARMC5	0.008	0.06	bioplex_WMM WMM_only
KCTD20	ARMC5	0.008	0.06	bioplex_WMM WMM_only
KLHL8	KLHL24	0.008	0.044	hein_WMM bioplex_WMM WMM_only
KLHL8	ANKRD39	0.008	0.042	bioplex_WMM WMM_only
KBTBD6	KCTD20	0.008	0.037	hein_WMM bioplex_WMM WMM_only
KLHL23	ANKRD39	0.008	0.037	bioplex_WMM WMM_only
KCTD6	BTBD10	0.008	0.034	bioplex_WMM WMM_only
BTBD10	KLHL11	0.008	0.034	bioplex_WMM WMM_only
KLHL24	ANKRD39	0.008	0.033	bioplex_WMM WMM_only
KBTBD6	BTBD10	0.008	0.029	hein_WMM bioplex_WMM WMM_only
KLHL42	KCTD6	0.008	0.028	bioplex_WMM WMM_only
KLHL42	KLHL8	0.008	0.027	hein_WMM bioplex_WMM WMM_only
KCTD6	LRRC42	0.008	0.012	bioplex_WMM WMM_only
KCTD6	ARMC5	0.008	0.012	bioplex_WMM WMM_only
ARMC5	KLHL11	0.008	0.012	bioplex_WMM WMM_only
KCTD20	KCTD6	0.008	0.012	bioplex_WMM WMM_only
KCTD20	KLHL11	0.008	0.012	bioplex_WMM WMM_only
LRRC42	KLHL11	0.008	0.012	bioplex_WMM WMM_only
KCTD6	KLHL24	0.008	0.011	bioplex_WMM WMM_only
KLHL42	ANKRD39	0.008	0.012	bioplex_WMM WMM_only
KLHL23	BTBD10	0.007	0.005	bioplex_WMM WMM_only
KLHL23	KLHL24	0.007	0.007	bioplex_WMM WMM_only
KLHL8	LRRC42	0.007	0.008	bioplex_WMM WMM_only
KLHL8	ARMC5	0.007	0.008	bioplex_WMM WMM_only
KBTBD6	ARMC5	0.007	0.009	bioplex_WMM WMM_only
KCTD20	KLHL23	0.007	0.004	bioplex_WMM WMM_only
KLHL23	LRRC42	0.007	0.004	bioplex_WMM WMM_only
KLHL24	ARMC5	0.007	0.003	bioplex_WMM WMM_only
LRRC42	KLHL24	0.007	0.003	bioplex_WMM WMM_only
KBTBD6	ANKRD39	0.007	0.009	bioplex_WMM WMM_only
KCTD6	KLHL11	0.007	0.008	bioplex_WMM WMM_only
KBTBD6	KLHL24	0.007	0.008	hein_WMM bioplex_WMM WMM_only
KLHL42	LRRC42	0.007	0.005	bioplex_WMM WMM_only
KLHL42	ARMC5	0.007	0.005	bioplex_WMM WMM_only
KLHL8	KLHL11	0.007	0.004	bioplex_WMM WMM_only
KLHL8	KCTD6	0.007	0.004	bioplex_WMM WMM_only
KBTBD6	KLHL8	0.007	0.009	hein_WMM bioplex_WMM WMM_only
KCTD6	KLHL23	0.007	0.004	bioplex_WMM WMM_only
KLHL23	KLHL11	0.007	0.004	bioplex_WMM WMM_only
KLHL24	KLHL11	0.007	0.003	bioplex_WMM WMM_only
KBTBD6	LRRC42	0.007	0.002	bioplex_WMM WMM_only
KLHL8	KLHL23	0.007	0.002	bioplex_WMM WMM_only
KLHL42	KLHL11	0.007	0.008	bioplex_WMM WMM_only
KBTBD6	KCTD6	0.007	0.004	bioplex_WMM WMM_only
KBTBD6	KLHL11	0.007	0.005	bioplex_WMM WMM_only
KLHL42	KLHL23	0.007	0.001	bioplex_WMM WMM_only
KBTBD6	KLHL42	0.006	0.004	hein_WMM bioplex_WMM WMM_only
KBTBD6	KLHL23	0.006	0.004	bioplex_WMM WMM_only

Images

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Complex HuMAP2_03890 has an average edge precision of 0.104 which is ranked 6923 out of all 6965 complexes.

Related Complexes

Genename	Complexes
KLHL42	HuMAP2_00866 HuMAP2_03890 HuMAP2_05391 HuMAP2_05454 HuMAP2_05548 HuMAP2_06858
KCTD20	HuMAP2_00866 HuMAP2_03465 HuMAP2_03890 HuMAP2_05859
KLHL24	HuMAP2_03890 HuMAP2_05647 HuMAP2_06858
KLHL8	HuMAP2_00866 HuMAP2_01368 HuMAP2_03890 HuMAP2_05647
BTBD10	HuMAP2_03465 HuMAP2_03762 HuMAP2_03890 HuMAP2_05859
ANKRD39	HuMAP2_03890 HuMAP2_05647
CUL3	HuMAP2_00866 HuMAP2_03890 HuMAP2_05391 HuMAP2_05647
ARMC5	HuMAP2_03890 HuMAP2_05647 HuMAP2_06931
KLHL23	HuMAP2_03191 HuMAP2_03890
LRRC42	HuMAP2_03259 HuMAP2_03890 HuMAP2_05576
KCTD6	HuMAP2_01352 HuMAP2_03890 HuMAP2_05548
KBTBD6	HuMAP2_00866 HuMAP2_01025 HuMAP2_01891 HuMAP2_03890 HuMAP2_05857 HuMAP2_06041
KLHL11	HuMAP2_03890 HuMAP2_05546 HuMAP2_06534

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_03890