hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03895
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CLTC | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | UniProt NCBI |
| FLNA | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | UniProt NCBI |
| ACTG1 | Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | UniProt NCBI |
| CLTB | Clathrin light chain B (Lcb) | UniProt NCBI |
| CLTA | Clathrin light chain A (Lca) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-196025 | 1.20471669305e-10 | 0.8 | CLTB ACTG1 CLTC CLTA | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 1.80697791373e-10 | 0.8 | CLTB ACTG1 CLTC CLTA | Gap junction degradation |
| WP:WP4217 | 1.06169472081e-09 | 1.0 | CLTB FLNA ACTG1 CLTC CLTA | Ebola Virus Pathway on Host |
| REAC:R-HSA-190828 | 1.69093561494e-08 | 0.8 | CLTB ACTG1 CLTC CLTA | Gap junction trafficking |
| REAC:R-HSA-157858 | 1.90901811802e-08 | 0.8 | CLTB ACTG1 CLTC CLTA | Gap junction trafficking and regulation |
| REAC:R-HSA-3928665 | 5.94611734259e-08 | 0.8 | CLTB ACTG1 CLTC CLTA | EPH-ephrin mediated repulsion of cells |
| KEGG:05100 | 1.2597344975e-07 | 0.8 | CLTB ACTG1 CLTC CLTA | Bacterial invasion of epithelial cells |
| REAC:R-HSA-2682334 | 7.72111985662e-07 | 0.8 | CLTB ACTG1 CLTC CLTA | EPH-Ephrin signaling |
| REAC:R-HSA-5140745 | 7.76884875116e-07 | 0.6 | CLTB CLTC CLTA | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-5099900 | 9.88662921473e-07 | 0.6 | CLTB CLTC CLTA | WNT5A-dependent internalization of FZD4 |
| REAC:R-HSA-8856828 | 3.99365490063e-06 | 0.8 | CLTB ACTG1 CLTC CLTA | Clathrin-mediated endocytosis |
| REAC:R-HSA-168275 | 1.34977069275e-05 | 0.4 | CLTC CLTA | Entry of Influenza Virion into Host Cell via Endocytosis |
| KEGG:04961 | 1.68726386421e-05 | 0.6 | CLTB CLTC CLTA | Endocrine and other factor-regulated calcium reabsorption |
| REAC:R-HSA-432720 | 1.77393158174e-05 | 0.6 | CLTB CLTC CLTA | Lysosome Vesicle Biogenesis |
| REAC:R-HSA-437239 | 3.84212387398e-05 | 0.6 | ACTG1 CLTC CLTA | Recycling pathway of L1 |
| KEGG:04721 | 4.11682217947e-05 | 0.6 | CLTB CLTC CLTA | Synaptic vesicle cycle |
| CORUM:2837 | 0.000100576175246 | 0.4 | ACTG1 CLTC | Profilin 1 complex |
| REAC:R-HSA-199992 | 0.000161043167075 | 0.6 | CLTB CLTC CLTA | trans-Golgi Network Vesicle Budding |
| WP:WP4549 | 0.000164232093757 | 0.6 | CLTB CLTC CLTA | Fragile X Syndrome |
| GO:0048268 | 0.000199619769136 | 0.6 | CLTB CLTC CLTA | clathrin coat assembly |
| KEGG:04142 | 0.000228199807064 | 0.6 | CLTB CLTC CLTA | Lysosome |
| REAC:R-HSA-8856825 | 0.000306125075711 | 0.6 | CLTB CLTC CLTA | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-4086400 | 0.000327410819085 | 0.6 | CLTB CLTC CLTA | PCP/CE pathway |
| REAC:R-HSA-373760 | 0.000596598643168 | 0.6 | ACTG1 CLTC CLTA | L1CAM interactions |
| KEGG:05016 | 0.000759162382225 | 0.6 | CLTB CLTC CLTA | Huntington disease |
| REAC:R-HSA-8866427 | 0.000889652787086 | 0.4 | CLTC CLTA | VLDLR internalisation and degradation |
| REAC:R-HSA-422475 | 0.00101311640921 | 0.8 | CLTB ACTG1 CLTC CLTA | Axon guidance |
| REAC:R-HSA-177504 | 0.00105126658749 | 0.4 | CLTC CLTA | Retrograde neurotrophin signalling |
| REAC:R-HSA-3858494 | 0.00112457746833 | 0.6 | CLTB CLTC CLTA | Beta-catenin independent WNT signaling |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | CLTB ACTG1 CLTC CLTA | Membrane Trafficking |
| KEGG:04144 | 0.00171388219445 | 0.6 | CLTB CLTC CLTA | Endocytosis |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | CLTB ACTG1 CLTC CLTA | Vesicle-mediated transport |
| REAC:R-HSA-446353 | 0.00206071490935 | 0.4 | FLNA ACTG1 | Cell-extracellular matrix interactions |
| GO:0030118 | 0.00208420080219 | 0.6 | CLTB CLTC CLTA | clathrin coat |
| REAC:R-HSA-8964038 | 0.00230284247734 | 0.4 | CLTC CLTA | LDL clearance |
| WP:WP2267 | 0.00343593293187 | 0.4 | CLTC CLTA | Synaptic Vesicle Pathway |
| GO:0072583 | 0.00407078924856 | 0.6 | CLTB CLTC CLTA | clathrin-dependent endocytosis |
| GO:0099631 | 0.00450823411379 | 0.4 | CLTB CLTA | postsynaptic endocytic zone cytoplasmic component |
| REAC:R-HSA-8964043 | 0.00546022370076 | 0.4 | CLTC CLTA | Plasma lipoprotein clearance |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | CLTB FLNA ACTG1 CLTC CLTA | Signal Transduction |
| KEGG:05132 | 0.00941045001151 | 0.4 | FLNA ACTG1 | Salmonella infection |
| GO:0030276 | 0.00964423896068 | 0.6 | CLTB CLTC CLTA | clathrin binding |
| REAC:R-HSA-1266738 | 0.0103415798479 | 0.8 | CLTB ACTG1 CLTC CLTA | Developmental Biology |
| GO:0045334 | 0.0103850554114 | 0.6 | CLTB CLTC CLTA | clathrin-coated endocytic vesicle |
| REAC:R-HSA-195721 | 0.0129604262881 | 0.6 | CLTB CLTC CLTA | Signaling by WNT |
| REAC:R-HSA-174824 | 0.0206361227401 | 0.4 | CLTC CLTA | Plasma lipoprotein assembly, remodeling, and clearance |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | ACTG1 CLTC CLTA | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-446728 | 0.0332320424718 | 0.4 | FLNA ACTG1 | Cell junction organization |
| REAC:R-HSA-187037 | 0.0351349281697 | 0.4 | CLTC CLTA | Signaling by NTRK1 (TRKA) |
| CORUM:6691 | 0.0499494897235 | 0.2 | CLTC | CLTC-PI4K2A complex |
| CORUM:6720 | 0.0499494897235 | 0.2 | FLNA | FILIP1-FLNA complex |
| CORUM:7269 | 0.0499494897235 | 0.2 | CLTC | p532-Clathrin-HSP70 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CLTC | CLTA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CLTC) Malo gupta_WMM fraction boldt_WMM |
| CLTC | CLTB | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (CLTB,CLTC) fraction boldt_WMM |
| CLTB | CLTA | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (CLTB) fraction boldt_WMM |
| CLTC | FLNA | 0.981 | 0.897 | hein_WMM bioplex_WMM Guru boldt hein (FLNA) fraction boldt_WMM treiber_WMM |
| CLTC | ACTG1 | 0.932 | 0.847 | hein_WMM boldt gupta_WMM fraction boldt_WMM |
| FLNA | CLTA | 0.779 | 0.753 | hein_WMM bioplex_WMM hein (FLNA) fraction |
| CLTB | FLNA | 0.107 | 0.372 | hein_WMM bioplex_WMM hein (FLNA) fraction |
| ACTG1 | FLNA | 0.036 | 0.265 | hein_WMM hein (FLNA) fraction boldt_WMM |
| ACTG1 | CLTB | 0.003 | 0.012 | hein_WMM WMM_only |
| ACTG1 | CLTA | 0.0 | 0.011 | hein_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_03895 has an average edge precision of 0.6 which is ranked 1946 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CLTC | HuMAP2_01298 HuMAP2_01713 HuMAP2_02813 HuMAP2_03895 HuMAP2_06916 |
| FLNA | HuMAP2_02813 HuMAP2_03895 HuMAP2_05328 HuMAP2_05368 |
| ACTG1 | HuMAP2_02160 HuMAP2_03895 HuMAP2_06706 HuMAP2_06976 |
| CLTB | HuMAP2_02565 HuMAP2_03676 HuMAP2_03895 HuMAP2_06848 |
| CLTA | HuMAP2_02813 HuMAP2_03895 HuMAP2_06916 |