hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03901
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSD17B8 | Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) | UniProt NCBI |
| CBR4 | Carbonyl reductase family member 4 (EC 1.-.-.-) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Quinone reductase CBR4) (Short chain dehydrogenase/reductase family 45C member 1) | UniProt NCBI |
| PPAT | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) | UniProt NCBI |
| MOCOS | Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) | UniProt NCBI |
| IARS2 | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00061 | 0.000514258658532 | 0.4 | CBR4 HSD17B8 | Fatty acid biosynthesis |
| GO:0047025 | 0.00450823411379 | 0.4 | CBR4 HSD17B8 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity |
| KEGG:01212 | 0.00587609842855 | 0.4 | CBR4 HSD17B8 | Fatty acid metabolism |
| REAC:R-HSA-75105 | 0.00625202329777 | 0.4 | CBR4 HSD17B8 | Fatty acyl-CoA biosynthesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CBR4 | HSD17B8 | 0.899 | 0.823 | bioplex (HSD17B8) bioplex_WMM |
| HSD17B8 | MOCOS | 0.624 | 0.678 | bioplex (HSD17B8) bioplex_WMM |
| IARS2 | HSD17B8 | 0.094 | 0.356 | bioplex (HSD17B8) bioplex_WMM youn_WMM fraction |
| IARS2 | PPAT | 0.043 | 0.27 | bioplex (IARS2) bioplex_WMM youn_WMM fraction |
| PPAT | CBR4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| IARS2 | MOCOS | 0.007 | 0.0 | bioplex_WMM WMM_only |
| CBR4 | MOCOS | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PPAT | MOCOS | 0.006 | 0.004 | bioplex_WMM WMM_only |
| IARS2 | CBR4 | 0.003 | 0.018 | bioplex_WMM WMM_only |
| PPAT | HSD17B8 | 0.0 | 0.013 | fraction |
Images
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Complex HuMAP2_03901 has an average edge precision of 0.217 which is ranked 5904 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSD17B8 | HuMAP2_02684 HuMAP2_03791 HuMAP2_03901 HuMAP2_04402 |
| CBR4 | HuMAP2_02684 HuMAP2_03791 HuMAP2_03901 HuMAP2_04402 |
| PPAT | HuMAP2_01042 HuMAP2_01476 HuMAP2_02684 HuMAP2_03901 HuMAP2_05568 HuMAP2_05918 |
| MOCOS | HuMAP2_03791 HuMAP2_03901 HuMAP2_04295 HuMAP2_04985 |
| IARS2 | HuMAP2_01042 HuMAP2_02684 HuMAP2_03901 HuMAP2_05918 |