hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03911

Confidence: Medium

Genename	Protein Name	Links
WASHC3	WASH complex subunit 3 (Coiled-coil domain-containing protein 53)	UniProt NCBI
PMEL	Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta]	UniProt NCBI
WASHC2A	WASH complex subunit 2A	UniProt NCBI
RB1CC1	RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)	UniProt NCBI
ATG101	Autophagy-related protein 101	UniProt NCBI
WASHC4	WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)	UniProt NCBI
BLOC1S4	Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog)	UniProt NCBI
FAM221B	Protein FAM221B	UniProt NCBI
ULK1	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)	UniProt NCBI
WASHC5	WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)	UniProt NCBI
TMEM167A	Protein kish-A (Transmembrane protein 167) (Transmembrane protein 167A)	UniProt NCBI
IER3IP1	Immediate early response 3-interacting protein 1	UniProt NCBI
ATG13	Autophagy-related protein 13	UniProt NCBI
WASH3P		NCBI
MGAT4A	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]	UniProt NCBI
WASH6P		NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7091	2.59786775674e-11	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	FIP200-ULK1-ATG13-ATG101 complex
CORUM:6232	2.59786775674e-11	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	ULK1-ATG13-RB1CC1-ATG101 complex
CORUM:7065	9.0778889965e-10	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex
CORUM:6229	3.51680443324e-08	0.214285714286	ULK1 RB1CC1 ATG13	ULK1-ATG13-RB1CC1 complex
CORUM:6481	3.51290867842e-07	0.214285714286	WASHC4 WASHC3 WASHC5	WASH complex
CORUM:6484	1.22815598808e-06	0.214285714286	WASHC4 WASHC3 WASHC5	WASH-CAPZalpa/beta complex
WP:WP4577	4.26462497496e-06	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway
GO:0071203	8.02832390368e-06	0.285714285714	WASHC5 WASHC4 WASHC3 WASHC2A	WASH complex
CORUM:6671	1.2723363426e-05	0.214285714286	WASHC4 WASHC5 WASHC2A	PI4K2A-WASH complex
KEGG:04211	4.35242688747e-05	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	Longevity regulating pathway
CORUM:6230	0.000130860292961	0.142857142857	RB1CC1 ATG13	ULK2-ATG13-RB1CC1 complex
WP:WP3844	0.000191071678795	0.214285714286	ULK1 RB1CC1 ATG13	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
CORUM:6816	0.00026157999168	0.142857142857	ULK1 ATG13	ULK1-ATG13-ATG14-PIK3C3 complex
REAC:R-HSA-1632852	0.000263866791067	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	Macroautophagy
KEGG:04140	0.000301586216266	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	Autophagy - animal
GO:0000407	0.000360785878699	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	phagophore assembly site
REAC:R-HSA-9612973	0.000519615291636	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	Autophagy
GO:1990316	0.00184612317041	0.214285714286	ULK1 RB1CC1 ATG13	Atg1/ULK1 kinase complex
KEGG:04144	0.00265383031773	0.285714285714	WASHC5 WASHC4 WASHC3 WASHC2A	Endocytosis
WP:WP615	0.00517246893741	0.214285714286	ULK1 RB1CC1 ATG13	Senescence and Autophagy in Cancer
KEGG:04136	0.0199592939309	0.142857142857	ATG13 ATG101	Autophagy - other
GO:0000045	0.0352397763742	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	autophagosome assembly
GO:1905037	0.0370745215367	0.285714285714	ULK1 RB1CC1 ATG101 ATG13	autophagosome organization

Edges

Protein 1	Protein 2	Score	Precision	Evidence
WASHC3	WASH3P	0.993	0.918	bioplex (WASHC3) bioplex_WMM boldt_WMM
WASHC3	WASHC4	0.984	0.899	bioplex (WASHC3) bioplex_WMM gupta_WMM boldt_WMM
WASHC3	WASHC5	0.984	0.899	bioplex (WASHC3) bioplex_WMM gupta_WMM boldt_WMM
WASHC3	WASHC2A	0.98	0.896	bioplex (WASHC3) bioplex_WMM gupta_WMM fraction boldt_WMM
WASHC3	WASH6P	0.969	0.88	bioplex (WASHC3) bioplex_WMM
WASHC3	MGAT4A	0.606	0.672	bioplex (WASHC3) bioplex_WMM
WASHC3	IER3IP1	0.591	0.664	bioplex (WASHC3) bioplex_WMM
WASHC4	WASHC5	0.372	0.547	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
WASHC3	RB1CC1	0.249	0.472	bioplex (WASHC3) bioplex_WMM
RB1CC1	FAM221B	0.234	0.47	bioplex (FAM221B) bioplex_WMM
ATG101	FAM221B	0.187	0.44	bioplex (FAM221B) bioplex_WMM
WASHC3	ATG101	0.179	0.438	bioplex (WASHC3) bioplex_WMM
IER3IP1	PMEL	0.099	0.358	bioplex (PMEL) bioplex_WMM
WASHC3	ATG13	0.092	0.356	bioplex (WASHC3) bioplex_WMM
IER3IP1	TMEM167A	0.088	0.353	bioplex (IER3IP1) bioplex_WMM
WASHC3	BLOC1S4	0.077	0.353	bioplex (WASHC3) bioplex_WMM
WASHC3	TMEM167A	0.062	0.345	bioplex (WASHC3) bioplex_WMM
ULK1	WASHC3	0.05	0.297	bioplex (WASHC3) bioplex_WMM
ATG13	FAM221B	0.039	0.264	bioplex (FAM221B) bioplex_WMM
WASHC5	WASHC2A	0.033	0.253	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
WASHC4	WASHC2A	0.017	0.167	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
WASHC5	WASH3P	0.012	0.145	bioplex_WMM WMM_only boldt_WMM
WASHC2A	WASH3P	0.012	0.145	bioplex_WMM WMM_only boldt_WMM
WASHC4	WASH3P	0.012	0.147	bioplex_WMM WMM_only boldt_WMM
WASH6P	WASHC5	0.012	0.149	bioplex_WMM WMM_only
WASH6P	WASH3P	0.012	0.149	bioplex_WMM WMM_only
WASH6P	WASHC2A	0.012	0.149	bioplex_WMM WMM_only
WASH6P	WASHC4	0.012	0.152	bioplex_WMM WMM_only
ATG13	RB1CC1	0.011	0.145	bioplex_WMM WMM_only
ULK1	ATG101	0.011	0.141	bioplex_WMM WMM_only
ULK1	FAM221B	0.01	0.131	bioplex (FAM221B) bioplex_WMM
ULK1	ATG13	0.01	0.128	bioplex_WMM WMM_only
ATG13	ATG101	0.01	0.128	bioplex_WMM WMM_only
ULK1	RB1CC1	0.009	0.107	bioplex_WMM WMM_only
RB1CC1	ATG101	0.009	0.107	bioplex_WMM WMM_only
MGAT4A	WASHC4	0.008	0.093	bioplex_WMM WMM_only
MGAT4A	WASH6P	0.008	0.091	bioplex_WMM WMM_only
MGAT4A	ATG101	0.008	0.091	bioplex_WMM WMM_only
MGAT4A	TMEM167A	0.008	0.091	bioplex_WMM WMM_only
MGAT4A	WASHC5	0.008	0.091	bioplex_WMM WMM_only
MGAT4A	WASH3P	0.008	0.091	bioplex_WMM WMM_only
ULK1	MGAT4A	0.008	0.091	bioplex_WMM WMM_only
MGAT4A	WASHC2A	0.008	0.091	bioplex_WMM WMM_only
MGAT4A	BLOC1S4	0.008	0.088	bioplex_WMM WMM_only
MGAT4A	ATG13	0.008	0.087	bioplex_WMM WMM_only
MGAT4A	IER3IP1	0.008	0.087	bioplex_WMM WMM_only
WASHC4	TMEM167A	0.008	0.086	bioplex_WMM WMM_only
ATG101	WASHC4	0.008	0.086	bioplex_WMM WMM_only
ULK1	WASHC4	0.008	0.086	bioplex_WMM WMM_only
ULK1	TMEM167A	0.008	0.085	bioplex_WMM WMM_only
ULK1	WASHC5	0.008	0.085	bioplex_WMM WMM_only
WASHC5	TMEM167A	0.008	0.085	bioplex_WMM WMM_only
ULK1	WASH3P	0.008	0.085	bioplex_WMM WMM_only
ATG101	WASH3P	0.008	0.085	bioplex_WMM WMM_only
WASH3P	TMEM167A	0.008	0.085	bioplex_WMM WMM_only
ATG101	WASHC5	0.008	0.085	bioplex_WMM WMM_only
ULK1	WASH6P	0.008	0.085	bioplex_WMM WMM_only
WASH6P	TMEM167A	0.008	0.085	bioplex_WMM WMM_only
ATG101	TMEM167A	0.008	0.085	bioplex_WMM WMM_only
ULK1	WASHC2A	0.008	0.085	bioplex_WMM WMM_only
WASH6P	ATG101	0.008	0.085	bioplex_WMM WMM_only
ATG101	WASHC2A	0.008	0.085	bioplex_WMM WMM_only
WASHC2A	TMEM167A	0.008	0.085	bioplex_WMM WMM_only
WASHC4	BLOC1S4	0.008	0.065	bioplex_WMM WMM_only
ATG13	WASHC4	0.008	0.066	bioplex_WMM WMM_only
WASHC4	IER3IP1	0.008	0.066	bioplex_WMM WMM_only
WASHC5	BLOC1S4	0.008	0.066	bioplex_WMM WMM_only
WASH6P	BLOC1S4	0.008	0.066	bioplex_WMM WMM_only
ULK1	BLOC1S4	0.008	0.066	bioplex_WMM WMM_only
BLOC1S4	TMEM167A	0.008	0.066	bioplex_WMM WMM_only
ATG101	BLOC1S4	0.008	0.066	bioplex_WMM WMM_only
WASHC2A	BLOC1S4	0.008	0.066	bioplex_WMM WMM_only
WASH3P	BLOC1S4	0.008	0.066	bioplex_WMM WMM_only
WASH6P	IER3IP1	0.008	0.067	bioplex_WMM WMM_only
ULK1	IER3IP1	0.008	0.067	bioplex_WMM WMM_only
WASHC2A	IER3IP1	0.008	0.067	bioplex_WMM WMM_only
ATG13	WASH3P	0.008	0.067	bioplex_WMM WMM_only
WASHC5	IER3IP1	0.008	0.067	bioplex_WMM WMM_only
ATG13	WASHC2A	0.008	0.067	bioplex_WMM WMM_only
ATG101	IER3IP1	0.008	0.067	bioplex_WMM WMM_only
ATG13	TMEM167A	0.008	0.067	bioplex_WMM WMM_only
ATG13	WASHC5	0.008	0.067	bioplex_WMM WMM_only
IER3IP1	WASH3P	0.008	0.067	bioplex_WMM WMM_only
ATG13	WASH6P	0.008	0.067	bioplex_WMM WMM_only
MGAT4A	RB1CC1	0.008	0.066	bioplex_WMM WMM_only
ATG13	BLOC1S4	0.008	0.06	bioplex_WMM WMM_only
IER3IP1	BLOC1S4	0.008	0.06	bioplex_WMM WMM_only
ATG13	IER3IP1	0.008	0.06	bioplex_WMM WMM_only
RB1CC1	WASHC2A	0.008	0.035	bioplex_WMM youn_WMM WMM_only
RB1CC1	WASHC4	0.008	0.039	bioplex_WMM WMM_only
RB1CC1	WASH3P	0.008	0.034	bioplex_WMM WMM_only
RB1CC1	WASHC5	0.008	0.034	bioplex_WMM WMM_only
RB1CC1	TMEM167A	0.008	0.034	bioplex_WMM WMM_only
WASH6P	RB1CC1	0.008	0.034	bioplex_WMM WMM_only
RB1CC1	BLOC1S4	0.008	0.015	bioplex_WMM WMM_only
RB1CC1	IER3IP1	0.008	0.012	bioplex_WMM WMM_only

Images

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Complex HuMAP2_03911 has an average edge precision of 0.179 which is ranked 6434 out of all 6965 complexes.

Related Complexes

Genename	Complexes
WASHC3	HuMAP2_00117 HuMAP2_02649 HuMAP2_03043 HuMAP2_03789 HuMAP2_03866 HuMAP2_03911 HuMAP2_03993 HuMAP2_04508 HuMAP2_05737 HuMAP2_06865
PMEL	HuMAP2_03911 HuMAP2_05862
WASHC2A	HuMAP2_02312 HuMAP2_03866 HuMAP2_03911 HuMAP2_06474
RB1CC1	HuMAP2_00357 HuMAP2_03547 HuMAP2_03911
ATG101	HuMAP2_00357 HuMAP2_03547 HuMAP2_03911
WASHC4	HuMAP2_01679 HuMAP2_03911 HuMAP2_05737
BLOC1S4	HuMAP2_03911
FAM221B	HuMAP2_00357 HuMAP2_03547 HuMAP2_03911
ULK1	HuMAP2_00117 HuMAP2_03789 HuMAP2_03911
WASHC5	HuMAP2_01679 HuMAP2_03043 HuMAP2_03911
TMEM167A	HuMAP2_03911 HuMAP2_05862
IER3IP1	HuMAP2_03043 HuMAP2_03866 HuMAP2_03911 HuMAP2_03993 HuMAP2_04508 HuMAP2_05737 HuMAP2_05862 HuMAP2_06865
ATG13	HuMAP2_00117 HuMAP2_03547 HuMAP2_03789 HuMAP2_03911
WASH3P	HuMAP2_03789 HuMAP2_03911 HuMAP2_06865
MGAT4A	HuMAP2_00117 HuMAP2_03043 HuMAP2_03789 HuMAP2_03866 HuMAP2_03911 HuMAP2_03993 HuMAP2_04508 HuMAP2_05737 HuMAP2_06865
WASH6P	HuMAP2_00117 HuMAP2_03911 HuMAP2_04508

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03911