hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03913
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HIST1H2BD | Histone H2B type 1-D (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | UniProt NCBI |
| CETN2 | Centrin-2 (Caltractin isoform 1) | UniProt NCBI |
| HIST1H2BO | Histone H2B type 1-O (Histone H2B.2) (Histone H2B.n) (H2B/n) | UniProt NCBI |
| CETN3 | Centrin-3 | UniProt NCBI |
| POC5 | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73894 | 0.000503324377427 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | DNA Repair |
| KEGG:03420 | 0.00587890830807 | 0.333333333333 | CETN2 XPC | Nucleotide excision repair |
| REAC:R-HSA-5696394 | 0.0154864524203 | 0.333333333333 | CETN2 XPC | DNA Damage Recognition in GG-NER |
| GO:0065004 | 0.0184709841663 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | protein-DNA complex assembly |
| REAC:R-HSA-5696395 | 0.019874448248 | 0.333333333333 | CETN2 XPC | Formation of Incision Complex in GG-NER |
| GO:0071942 | 0.020283420769 | 0.333333333333 | CETN2 XPC | XPC complex |
| REAC:R-HSA-171306 | 0.0280217040903 | 0.333333333333 | HIST1H2BD HIST1H2BO | Packaging Of Telomere Ends |
| HPA:031020_02 | 0.0291699022884 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | ovary; ovarian stroma cells[Uncertain,Medium] |
| HPA:024020_03 | 0.0304850286776 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | kidney; cells in tubules[Uncertain,High] |
| REAC:R-HSA-110331 | 0.0314333263146 | 0.333333333333 | HIST1H2BD HIST1H2BO | Cleavage of the damaged purine |
| REAC:R-HSA-73927 | 0.0314333263146 | 0.333333333333 | HIST1H2BD HIST1H2BO | Depurination |
| REAC:R-HSA-110330 | 0.0314333263146 | 0.333333333333 | HIST1H2BD HIST1H2BO | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-8866654 | 0.0338154872995 | 0.333333333333 | HIST1H2BD HIST1H2BO | E3 ubiquitin ligases ubiquitinate target proteins |
| HPA:006010_02 | 0.0342540238325 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | caudate; glial cells[Uncertain,Medium] |
| REAC:R-HSA-110329 | 0.036283735834 | 0.333333333333 | HIST1H2BD HIST1H2BO | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-73928 | 0.036283735834 | 0.333333333333 | HIST1H2BD HIST1H2BO | Depyrimidination |
| REAC:R-HSA-110328 | 0.036283735834 | 0.333333333333 | HIST1H2BD HIST1H2BO | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73929 | 0.0375501136505 | 0.333333333333 | HIST1H2BD HIST1H2BO | Base-Excision Repair, AP Site Formation |
| KEGG:05322 | 0.0388413362769 | 0.333333333333 | HIST1H2BD HIST1H2BO | Systemic lupus erythematosus |
| REAC:R-HSA-73728 | 0.0414781208299 | 0.333333333333 | HIST1H2BD HIST1H2BO | RNA Polymerase I Promoter Opening |
| GO:0071103 | 0.0434575095048 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | DNA conformation change |
| REAC:R-HSA-5334118 | 0.0442040700727 | 0.333333333333 | HIST1H2BD HIST1H2BO | DNA methylation |
| GO:0071824 | 0.044962481783 | 0.666666666667 | XPC CETN2 HIST1H2BO HIST1H2BD | protein-DNA complex subunit organization |
| REAC:R-HSA-5625886 | 0.0470157324282 | 0.333333333333 | HIST1H2BD HIST1H2BO | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| REAC:R-HSA-427359 | 0.0484536768126 | 0.333333333333 | HIST1H2BD HIST1H2BO | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-68886 | 0.0498388977209 | 0.5 | CETN2 HIST1H2BO HIST1H2BD | M Phase |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XPC | CETN2 | 0.818 | 0.773 | hein_WMM bioplex (XPC) bioplex_WMM hein (CETN2) gupta (CETN2) |
| HIST1H2BD | XPC | 0.264 | 0.482 | hein_WMM bioplex (XPC) bioplex_WMM |
| HIST1H2BO | XPC | 0.182 | 0.438 | bioplex (XPC) bioplex_WMM |
| CETN2 | POC5 | 0.124 | 0.395 | hein_WMM bioplex (POC5) bioplex_WMM hein (CETN2) gupta (CETN2,POC5) |
| CETN2 | CETN3 | 0.104 | 0.37 | hein_WMM bioplex_WMM hein (CETN2) gupta_WMM |
| XPC | CETN3 | 0.051 | 0.3 | hein_WMM bioplex (XPC) bioplex_WMM |
| POC5 | CETN3 | 0.021 | 0.186 | hein_WMM bioplex (POC5) bioplex_WMM youn_WMM gupta (POC5) |
| HIST1H2BD | HIST1H2BO | 0.011 | 0.141 | bioplex_WMM WMM_only |
| HIST1H2BO | CETN2 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| XPC | POC5 | 0.008 | 0.086 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| HIST1H2BD | CETN3 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| HIST1H2BO | CETN3 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| HIST1H2BO | POC5 | 0.007 | 0.0 | youn_WMM WMM_only |
| HIST1H2BD | CETN2 | 0.006 | 0.006 | bioplex_WMM gupta (CETN2) |
| HIST1H2BD | POC5 | 0.004 | 0.01 | gupta (POC5) |
Images
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Complex HuMAP2_03913 has an average edge precision of 0.219 which is ranked 5867 out of all 6965 complexes.
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