hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03916
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | UniProt NCBI |
| DNM2 | Dynamin-2 (EC 3.6.5.5) | UniProt NCBI |
| DNM1 | Dynamin-1 (EC 3.6.5.5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 1.28584716548e-07 | 1.0 | DNM1 DNM3 DNM2 | Retrograde neurotrophin signalling |
| GO:0098844 | 3.63274304092e-07 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic endocytic zone membrane |
| KEGG:04961 | 5.89418572865e-07 | 1.0 | DNM1 DNM3 DNM2 | Endocrine and other factor-regulated calcium reabsorption |
| GO:0044327 | 9.08185760231e-07 | 1.0 | DNM1 DNM3 DNM2 | dendritic spine head |
| WP:WP2267 | 9.77748924845e-07 | 1.0 | DNM1 DNM3 DNM2 | Synaptic Vesicle Pathway |
| KEGG:04721 | 1.44061718026e-06 | 1.0 | DNM1 DNM3 DNM2 | Synaptic vesicle cycle |
| GO:0016185 | 1.81637152046e-06 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0140239 | 1.81637152046e-06 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic endocytosis |
| GO:0098884 | 1.81637152046e-06 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic neurotransmitter receptor internalization |
| KEGG:05100 | 1.87038150806e-06 | 1.0 | DNM1 DNM3 DNM2 | Bacterial invasion of epithelial cells |
| GO:0070142 | 3.17865016081e-06 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle budding |
| GO:0098843 | 3.17865016081e-06 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic endocytic zone |
| REAC:R-HSA-437239 | 6.37978016717e-06 | 1.0 | DNM1 DNM3 DNM2 | Recycling pathway of L1 |
| KEGG:04072 | 9.78855844223e-06 | 1.0 | DNM1 DNM3 DNM2 | Phospholipase D signaling pathway |
| GO:0099590 | 1.08982291228e-05 | 1.0 | DNM1 DNM3 DNM2 | neurotransmitter receptor internalization |
| REAC:R-HSA-187037 | 2.79631294769e-05 | 1.0 | DNM1 DNM3 DNM2 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-166520 | 5.46192807335e-05 | 1.0 | DNM1 DNM3 DNM2 | Signaling by NTRKs |
| KEGG:04144 | 6.09806140287e-05 | 1.0 | DNM1 DNM3 DNM2 | Endocytosis |
| REAC:R-HSA-373760 | 9.97273388147e-05 | 1.0 | DNM1 DNM3 DNM2 | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.000113954833063 | 1.0 | DNM1 DNM3 DNM2 | MHC class II antigen presentation |
| REAC:R-HSA-166016 | 0.000120004609098 | 1.0 | DNM1 DNM3 DNM2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-8856828 | 0.000157135918784 | 1.0 | DNM1 DNM3 DNM2 | Clathrin-mediated endocytosis |
| REAC:R-HSA-168898 | 0.000201230585428 | 1.0 | DNM1 DNM3 DNM2 | Toll-like Receptor Cascades |
| GO:0099637 | 0.00023612829766 | 1.0 | DNM1 DNM3 DNM2 | neurotransmitter receptor transport |
| GO:0099072 | 0.000265644334868 | 1.0 | DNM1 DNM3 DNM2 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| GO:0000266 | 0.000331851076788 | 1.0 | DNM1 DNM3 DNM2 | mitochondrial fission |
| REAC:R-HSA-196025 | 0.000368098478948 | 0.666666666667 | DNM1 DNM2 | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.000441698392473 | 0.666666666667 | DNM1 DNM2 | Gap junction degradation |
| GO:0048489 | 0.000543458358922 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle transport |
| GO:0048488 | 0.000594407580071 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle endocytosis |
| GO:0140238 | 0.000594407580071 | 1.0 | DNM1 DNM3 DNM2 | presynaptic endocytosis |
| GO:0097479 | 0.000897287531108 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle localization |
| GO:0036465 | 0.0011207920467 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle recycling |
| REAC:R-HSA-190828 | 0.00375073705264 | 0.666666666667 | DNM1 DNM2 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00397787610966 | 0.666666666667 | DNM1 DNM2 | Gap junction trafficking and regulation |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | DNM1 DNM3 DNM2 | Signaling by Receptor Tyrosine Kinases |
| GO:0043197 | 0.0051907357126 | 1.0 | DNM1 DNM3 DNM2 | dendritic spine |
| GO:0044309 | 0.00541641987402 | 1.0 | DNM1 DNM3 DNM2 | neuron spine |
| GO:0031623 | 0.00564855215433 | 1.0 | DNM1 DNM3 DNM2 | receptor internalization |
| WP:WP4549 | 0.0062557413218 | 0.666666666667 | DNM1 DNM2 | Fragile X Syndrome |
| GO:0045211 | 0.00804289309261 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic membrane |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | DNM1 DNM3 DNM2 | Axon guidance |
| GO:0006900 | 0.011404996777 | 1.0 | DNM1 DNM3 DNM2 | vesicle budding from membrane |
| GO:0099504 | 0.0129761581422 | 1.0 | DNM1 DNM3 DNM2 | synaptic vesicle cycle |
| GO:0099003 | 0.0133902908488 | 1.0 | DNM1 DNM3 DNM2 | vesicle-mediated transport in synapse |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | DNM1 DNM3 DNM2 | Membrane Trafficking |
| GO:0050803 | 0.0155935495032 | 1.0 | DNM1 DNM3 DNM2 | regulation of synapse structure or activity |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | DNM1 DNM3 DNM2 | Vesicle-mediated transport |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | DNM1 DNM3 DNM2 | Adaptive Immune System |
| GO:0097060 | 0.0261539335231 | 1.0 | DNM1 DNM3 DNM2 | synaptic membrane |
| GO:0014069 | 0.033252767518 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic density |
| GO:0099572 | 0.0364177948924 | 1.0 | DNM1 DNM3 DNM2 | postsynaptic specialization |
| GO:0032279 | 0.0364177948924 | 1.0 | DNM1 DNM3 DNM2 | asymmetric synapse |
| GO:0098984 | 0.0372392489125 | 1.0 | DNM1 DNM3 DNM2 | neuron to neuron synapse |
| GO:0043112 | 0.0380729634404 | 1.0 | DNM1 DNM3 DNM2 | receptor metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DNM2 | DNM3 | 0.994 | 0.921 | bioplex (DNM3) bioplex_WMM |
| DNM1 | DNM3 | 0.955 | 0.862 | bioplex (DNM3) bioplex_WMM |
| DNM2 | DNM1 | 0.011 | 0.148 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_03916 has an average edge precision of 0.644 which is ranked 1683 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DNM3 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM2 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM1 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |