hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03918
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HK1 | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) | UniProt NCBI |
| HK2 | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00524 | 1.45897544136e-06 | 1.0 | HK1 HK2 | Neomycin, kanamycin and gentamicin biosynthesis |
| KEGG:00052 | 5.12100379916e-05 | 1.0 | HK1 HK2 | Galactose metabolism |
| KEGG:00500 | 6.7842358023e-05 | 1.0 | HK1 HK2 | Starch and sucrose metabolism |
| KEGG:00051 | 7.70339033036e-05 | 1.0 | HK1 HK2 | Fructose and mannose metabolism |
| KEGG:04973 | 0.000113800084426 | 1.0 | HK1 HK2 | Carbohydrate digestion and absorption |
| KEGG:04930 | 0.000138019076752 | 1.0 | HK1 HK2 | Type II diabetes mellitus |
| KEGG:00520 | 0.00015100395818 | 1.0 | HK1 HK2 | Amino sugar and nucleotide sugar metabolism |
| WP:WP500 | 0.000261924676198 | 1.0 | HK1 HK2 | Glycogen Synthesis and Degradation |
| KEGG:00010 | 0.000284937903697 | 1.0 | HK1 HK2 | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.000322579470084 | 1.0 | HK1 HK2 | Central carbon metabolism in cancer |
| WP:WP534 | 0.000352461939805 | 1.0 | HK1 HK2 | Glycolysis and Gluconeogenesis |
| KEGG:04066 | 0.000722192843471 | 1.0 | HK1 HK2 | HIF-1 signaling pathway |
| KEGG:01200 | 0.000939726081777 | 1.0 | HK1 HK2 | Carbon metabolism |
| KEGG:04910 | 0.00113070596705 | 1.0 | HK1 HK2 | Insulin signaling pathway |
| WP:WP4018 | 0.00117735700823 | 1.0 | HK1 HK2 | Pathways in clear cell renal cell carcinoma |
| GO:0072656 | 0.00135247023414 | 1.0 | HK1 HK2 | maintenance of protein location in mitochondrion |
| REAC:R-HSA-70171 | 0.00359485582679 | 1.0 | HK1 HK2 | Glycolysis |
| GO:0019158 | 0.00450823411379 | 1.0 | HK1 HK2 | mannokinase activity |
| GO:0008865 | 0.00450823411379 | 1.0 | HK1 HK2 | fructokinase activity |
| GO:0004396 | 0.00450823411379 | 1.0 | HK1 HK2 | hexokinase activity |
| GO:0004340 | 0.00450823411379 | 1.0 | HK1 HK2 | glucokinase activity |
| REAC:R-HSA-70326 | 0.00556574181855 | 1.0 | HK1 HK2 | Glucose metabolism |
| GO:0006002 | 0.020287053512 | 1.0 | HK1 HK2 | fructose 6-phosphate metabolic process |
| REAC:R-HSA-5619056 | 0.0249595281251 | 0.5 | HK1 | Defective HK1 causes hexokinase deficiency (HK deficiency) |
| CORUM:7418 | 0.0499173803268 | 0.5 | HK1 | HK1-VDAC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HK1 | HK2 | 0.711 | 0.728 | bioplex (HK1) bioplex_WMM boldt youn_WMM boldt_WMM |
Images
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Complex HuMAP2_03918 has an average edge precision of 0.728 which is ranked 1277 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HK1 | HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918 |
| HK2 | HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918 |