hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03925
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC39A6 | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | UniProt NCBI |
| NCR3LG1 | Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) | UniProt NCBI |
| RYK | Tyrosine-protein kinase RYK (EC 2.7.10.1) | UniProt NCBI |
| PIP4P2 | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | UniProt NCBI |
| SLC39A5 | Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-442380 | 0.000485460775426 | 0.4 | SLC39A5 SLC39A6 | Zinc influx into cells by the SLC39 gene family |
| WP:WP3529 | 0.000842496056343 | 0.4 | SLC39A5 SLC39A6 | Zinc homeostasis |
| REAC:R-HSA-435354 | 0.00141478632427 | 0.4 | SLC39A5 SLC39A6 | Zinc transporters |
| REAC:R-HSA-425410 | 0.00282729215335 | 0.4 | SLC39A5 SLC39A6 | Metal ion SLC transporters |
| WP:WP2884 | 0.0200904134765 | 0.4 | SLC39A5 SLC39A6 | NRF2 pathway |
| REAC:R-HSA-425366 | 0.0221443716613 | 0.4 | SLC39A5 SLC39A6 | Transport of bile salts and organic acids, metal ions and amine compounds |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RYK | SLC39A5 | 0.034 | 0.257 | bioplex (SLC39A5) bioplex_WMM |
| SLC39A6 | SLC39A5 | 0.025 | 0.213 | bioplex (SLC39A5) bioplex_WMM |
| NCR3LG1 | RYK | 0.024 | 0.215 | bioplex (NCR3LG1) bioplex_WMM |
| PIP4P2 | SLC39A5 | 0.022 | 0.207 | bioplex (SLC39A5) bioplex_WMM |
| PIP4P2 | RYK | 0.007 | 0.009 | bioplex_WMM WMM_only |
| PIP4P2 | SLC39A6 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| NCR3LG1 | SLC39A6 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| RYK | SLC39A6 | 0.007 | 0.0 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03925 has an average edge precision of 0.114 which is ranked 6891 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC39A6 | HuMAP2_03925 |
| NCR3LG1 | HuMAP2_00400 HuMAP2_00930 HuMAP2_03925 HuMAP2_04802 |
| RYK | HuMAP2_00930 HuMAP2_01961 HuMAP2_03925 HuMAP2_04725 HuMAP2_04802 |
| PIP4P2 | HuMAP2_00123 HuMAP2_03925 |
| SLC39A5 | HuMAP2_03925 HuMAP2_06696 |