hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03926

Confidence: Medium High

Genename	Protein Name	Links
DICER1	Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)	UniProt NCBI
AGO2	Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)	UniProt NCBI
TARBP2	RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)	UniProt NCBI
TNRC6C	Trinucleotide repeat-containing gene 6C protein	UniProt NCBI
XPO1	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5381	1.35146690511e-09	0.6	DICER1 AGO2 TARBP2	RNA-induced silencing complex, RISC
CORUM:5377	1.35146690511e-09	0.6	DICER1 AGO2 TARBP2	RNA-induced silencing complex, RISC
CORUM:3032	5.40532307664e-09	0.6	DICER1 AGO2 TARBP2	RNA-induced silencing complex, RISC
CORUM:5378	2.70211703843e-08	0.6	DICER1 AGO2 TARBP2	TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10)
REAC:R-HSA-426486	2.28267971382e-07	0.6	DICER1 AGO2 TARBP2	Small interfering RNA (siRNA) biogenesis
GO:0035087	3.6323771075e-06	0.6	DICER1 AGO2 TARBP2	siRNA loading onto RISC involved in RNA interference
REAC:R-HSA-211000	4.38232313875e-06	0.8	DICER1 TNRC6C AGO2 TARBP2	Gene Silencing by RNA
REAC:R-HSA-203927	5.49186125546e-06	0.6	DICER1 AGO2 TARBP2	MicroRNA (miRNA) biogenesis
GO:0035197	1.81582264982e-05	0.6	DICER1 AGO2 TARBP2	siRNA binding
CORUM:1385	2.0123342217e-05	0.4	AGO2 DICER1	DICER1-NCOA6-AGO2 complex
GO:0035280	3.17736949706e-05	0.6	DICER1 AGO2 TARBP2	miRNA loading onto RISC involved in gene silencing by miRNA
WP:WP2805	5.00645850113e-05	0.4	AGO2 DICER1	exRNA mechanism of action and biogenesis
WP:WP2338	5.00645850113e-05	0.4	TARBP2 DICER1	miRNA Biogenesis
GO:0070578	7.62415024416e-05	0.6	DICER1 AGO2 TARBP2	RISC-loading complex
GO:0070922	7.62415024416e-05	0.6	DICER1 AGO2 TARBP2	small RNA loading onto RISC
GO:0030422	0.000108905457596	0.6	DICER1 AGO2 TARBP2	production of siRNA involved in RNA interference
WP:WP4549	0.000164232093757	0.6	DICER1 AGO2 TARBP2	Fragile X Syndrome
GO:0016442	0.000259479548289	0.6	DICER1 AGO2 TARBP2	RISC complex
GO:0031332	0.000259479548289	0.6	DICER1 AGO2 TARBP2	RNAi effector complex
REAC:R-HSA-426496	0.000283261545489	0.4	AGO2 TNRC6C	Post-transcriptional silencing by small RNAs
REAC:R-HSA-5687128	0.000285779749786	0.6	XPO1 AGO2 TNRC6C	MAPK6/MAPK4 signaling
REAC:R-HSA-8948700	0.000377631329325	0.4	AGO2 TNRC6C	Competing endogenous RNAs (ceRNAs) regulate PTEN translation
GO:0031054	0.000412725169389	0.6	DICER1 AGO2 TARBP2	pre-miRNA processing
GO:0016246	0.000412725169389	0.6	DICER1 AGO2 TARBP2	RNA interference
REAC:R-HSA-8943723	0.000485460775426	0.4	AGO2 TNRC6C	Regulation of PTEN mRNA translation
GO:0035195	0.00180327283687	0.8	DICER1 TNRC6C AGO2 TARBP2	gene silencing by miRNA
REAC:R-HSA-8934593	0.00183199274719	0.4	AGO2 TNRC6C	Regulation of RUNX1 Expression and Activity
GO:0010608	0.0019087106243	1.0	DICER1 TNRC6C AGO2 XPO1 TARBP2	posttranscriptional regulation of gene expression
GO:0035194	0.0023227175406	0.8	DICER1 TNRC6C AGO2 TARBP2	posttranscriptional gene silencing by RNA
GO:0016441	0.00238666327137	0.8	DICER1 TNRC6C AGO2 TARBP2	posttranscriptional gene silencing
GO:0010586	0.00296772889435	0.6	DICER1 AGO2 TARBP2	miRNA metabolic process
GO:1902555	0.00296772889435	0.6	DICER1 AGO2 TARBP2	endoribonuclease complex
GO:0031047	0.00310110311231	0.8	DICER1 TNRC6C AGO2 TARBP2	gene silencing by RNA
REAC:R-HSA-8939211	0.00371466203946	0.6	XPO1 AGO2 TNRC6C	ESR-mediated signaling
GO:1905348	0.0049400991777	0.6	DICER1 AGO2 TARBP2	endonuclease complex
REAC:R-HSA-9022692	0.00546022370076	0.4	AGO2 TNRC6C	Regulation of MECP2 expression and activity
REAC:R-HSA-5683057	0.00574411448248	0.6	XPO1 AGO2 TNRC6C	MAPK family signaling cascades
GO:0061980	0.005924931483	0.6	DICER1 AGO2 TARBP2	regulatory RNA binding
REAC:R-HSA-9006931	0.00634577840696	0.6	XPO1 AGO2 TNRC6C	Signaling by Nuclear Receptors
GO:0035196	0.0103850554114	0.6	DICER1 AGO2 TARBP2	production of miRNAs involved in gene silencing by miRNA
REAC:R-HSA-195721	0.0129604262881	0.6	XPO1 AGO2 TNRC6C	Signaling by WNT
GO:0016458	0.0134490676813	0.8	DICER1 TNRC6C AGO2 TARBP2	gene silencing
GO:0031050	0.0137266123698	0.6	DICER1 AGO2 TARBP2	dsRNA processing
GO:0070918	0.0137266123698	0.6	DICER1 AGO2 TARBP2	production of small RNA involved in gene silencing by RNA
GO:1990904	0.0163080003193	1.0	DICER1 TNRC6C AGO2 XPO1 TARBP2	ribonucleoprotein complex
REAC:R-HSA-8986944	0.0184727645209	0.4	AGO2 TNRC6C	Transcriptional Regulation by MECP2
REAC:R-HSA-4086398	0.0184727645209	0.4	AGO2 TNRC6C	Ca2+ pathway
MIRNA:hsa-miR-107	0.0190767333529	0.6	DICER1 AGO2 TARBP2	hsa-miR-107
MIRNA:hsa-miR-6841-3p	0.0224233322343	0.4	AGO2 TNRC6C	hsa-miR-6841-3p
WP:WP2943	0.0248637459957	0.2	DICER1	Hypoxia-mediated EMT and Stemness
GO:0030423	0.0270421395626	0.4	TARBP2 DICER1	targeting of mRNA for destruction involved in RNA interference
GO:0003725	0.0358473364726	0.6	DICER1 AGO2 TARBP2	double-stranded RNA binding
GO:0040029	0.0361255742156	0.8	DICER1 TNRC6C AGO2 TARBP2	regulation of gene expression, epigenetic
MIRNA:hsa-miR-4509	0.0362065585759	0.4	AGO2 TNRC6C	hsa-miR-4509
REAC:R-HSA-74160	0.038571388232	0.8	DICER1 TNRC6C AGO2 TARBP2	Gene expression (Transcription)
REAC:R-HSA-5628897	0.0422076786847	0.4	AGO2 TNRC6C	TP53 Regulates Metabolic Genes
WP:WP3302	0.0497141369515	0.2	XPO1	eIF5A regulation in response to inhibition of the nuclear export system
CORUM:1387	0.0499494897235	0.2	AGO2	TTP-AGO2 complex
CORUM:1117	0.0499494897235	0.2	XPO1	CRM1-Survivin mitotic complex
CORUM:5360	0.0499494897235	0.2	AGO2	AGO2-FXR1-TNF(alpha)ARE-RNP complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
DICER1	TARBP2	0.994	0.923	hein_WMM bioplex_WMM boldt youn_WMM hein (DICER1) boldt_WMM treiber_WMM
AGO2	TARBP2	0.155	0.416	hein_WMM youn (AGO2) bioplex_WMM youn_WMM hein (AGO2)
AGO2	TNRC6C	0.112	0.38	youn (AGO2,TNRC6C) bioplex_WMM youn_WMM
AGO2	DICER1	0.066	0.35	hein_WMM youn (AGO2) bioplex_WMM youn_WMM hein (AGO2)
XPO1	TNRC6C	0.058	0.323	youn (TNRC6C) bioplex_WMM youn_WMM gupta_WMM fraction
AGO2	XPO1	0.007	0.01	bioplex_WMM youn_WMM WMM_only treiber_WMM
XPO1	DICER1	0.007	0.004	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
XPO1	TARBP2	0.007	0.001	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
TNRC6C	TARBP2	0.006	0.011	bioplex_WMM youn_WMM WMM_only
TNRC6C	DICER1	0.005	0.011	bioplex_WMM youn_WMM WMM_only

Images

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Complex HuMAP2_03926 has an average edge precision of 0.243 which is ranked 5486 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DICER1	HuMAP2_03016 HuMAP2_03926 HuMAP2_06846
AGO2	HuMAP2_00288 HuMAP2_00976 HuMAP2_03926 HuMAP2_04674 HuMAP2_06846
TARBP2	HuMAP2_03016 HuMAP2_03926 HuMAP2_06846
TNRC6C	HuMAP2_00976 HuMAP2_03926
XPO1	HuMAP2_00741 HuMAP2_00976 HuMAP2_01855 HuMAP2_03926 HuMAP2_06176

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03926