hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03933
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DVL3 | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | UniProt NCBI |
| DVL2 | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5368598 | 1.00555407742e-05 | 1.0 | DVL3 DVL2 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins |
| REAC:R-HSA-201688 | 4.69258569465e-05 | 1.0 | DVL3 DVL2 | WNT mediated activation of DVL |
| KEGG:04330 | 0.000157715245211 | 1.0 | DVL3 DVL2 | Notch signaling pathway |
| WP:WP4150 | 0.000209018127094 | 1.0 | DVL3 DVL2 | Wnt Signaling in Kidney Disease |
| KEGG:05217 | 0.000224682217969 | 1.0 | DVL3 DVL2 | Basal cell carcinoma |
| WP:WP268 | 0.000276082766803 | 1.0 | DVL3 DVL2 | Notch Signaling |
| WP:WP363 | 0.0004381556461 | 1.0 | DVL3 DVL2 | Wnt Signaling Pathway |
| KEGG:04916 | 0.000571334782835 | 1.0 | DVL3 DVL2 | Melanogenesis |
| REAC:R-HSA-4641262 | 0.000729026706133 | 1.0 | DVL3 DVL2 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| WP:WP2064 | 0.0010618567954 | 1.0 | DVL3 DVL2 | Neural Crest Differentiation |
| KEGG:04550 | 0.00109466927365 | 1.0 | DVL3 DVL2 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP4336 | 0.00111886173915 | 1.0 | DVL3 DVL2 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:05224 | 0.00122335090758 | 1.0 | DVL3 DVL2 | Breast cancer |
| KEGG:05226 | 0.00124231758831 | 1.0 | DVL3 DVL2 | Gastric cancer |
| WP:WP4258 | 0.00139382676196 | 1.0 | DVL3 DVL2 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:04934 | 0.00144000876062 | 1.0 | DVL3 DVL2 | Cushing syndrome |
| KEGG:04390 | 0.00146058031434 | 1.0 | DVL3 DVL2 | Hippo signaling pathway |
| KEGG:04150 | 0.00150216111442 | 1.0 | DVL3 DVL2 | mTOR signaling pathway |
| KEGG:04310 | 0.00156562654612 | 1.0 | DVL3 DVL2 | Wnt signaling pathway |
| WP:WP399 | 0.00173473868048 | 1.0 | DVL3 DVL2 | Wnt Signaling Pathway and Pluripotency |
| WP:WP3931 | 0.00177087906966 | 1.0 | DVL3 DVL2 | ESC Pluripotency Pathways |
| KEGG:05225 | 0.00183261905189 | 1.0 | DVL3 DVL2 | Hepatocellular carcinoma |
| WP:WP710 | 0.00199554561268 | 1.0 | DVL3 DVL2 | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 0.00211290873217 | 1.0 | DVL3 DVL2 | Wnt Signaling |
| REAC:R-HSA-4641258 | 0.00267477384595 | 1.0 | DVL3 DVL2 | Degradation of DVL |
| GO:0042249 | 0.00270494046827 | 1.0 | DVL3 DVL2 | establishment of planar polarity of embryonic epithelium |
| GO:0090179 | 0.00270494046827 | 1.0 | DVL3 DVL2 | planar cell polarity pathway involved in neural tube closure |
| GO:0090178 | 0.00270494046827 | 1.0 | DVL3 DVL2 | regulation of establishment of planar polarity involved in neural tube closure |
| GO:0090177 | 0.00270494046827 | 1.0 | DVL3 DVL2 | establishment of planar polarity involved in neural tube closure |
| WP:WP4262 | 0.00357342755251 | 1.0 | DVL3 DVL2 | Breast cancer pathway |
| REAC:R-HSA-4086400 | 0.00686290657842 | 1.0 | DVL3 DVL2 | PCP/CE pathway |
| KEGG:05165 | 0.00707836525128 | 1.0 | DVL3 DVL2 | Human papillomavirus infection |
| GO:1905276 | 0.00946729163895 | 1.0 | DVL3 DVL2 | regulation of epithelial tube formation |
| GO:0150012 | 0.00946729163895 | 1.0 | DVL3 DVL2 | positive regulation of neuron projection arborization |
| REAC:R-HSA-5663220 | 0.0147112561527 | 1.0 | DVL3 DVL2 | RHO GTPases Activate Formins |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | DVL3 DVL2 | Beta-catenin independent WNT signaling |
| KEGG:05200 | 0.0157394270613 | 1.0 | DVL3 DVL2 | Pathways in cancer |
| GO:0150011 | 0.020287053512 | 1.0 | DVL3 DVL2 | regulation of neuron projection arborization |
| REAC:R-HSA-201681 | 0.0411120784555 | 1.0 | DVL3 DVL2 | TCF dependent signaling in response to WNT |
| HP:0010954 | 0.0497341708567 | 0.5 | DVL3 | Hypoplastic right heart |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DVL2 | DVL3 | 0.712 | 0.728 | bioplex (DVL3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_03933 has an average edge precision of 0.728 which is ranked 1277 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DVL3 | HuMAP2_03933 HuMAP2_04648 HuMAP2_05887 HuMAP2_06664 |
| DVL2 | HuMAP2_00482 HuMAP2_03933 HuMAP2_05124 HuMAP2_05871 HuMAP2_06664 |