hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03940
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HUWE1 | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | UniProt NCBI |
| EEF1B2 | Elongation factor 1-beta (EF-1-beta) | UniProt NCBI |
| MARCKSL1 | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | UniProt NCBI |
| EIF5B | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | UniProt NCBI |
| PTMA | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6984 | 4.0241279111e-05 | 0.4 | PTMA MARCKSL1 | ProTalpha C2 complex |
| WP:WP107 | 0.00406449637972 | 0.4 | EEF1B2 EIF5B | Translation Factors |
| HPA:050020_22 | 0.0394072538761 | 0.8 | HUWE1 MARCKSL1 PTMA EIF5B | spleen; cells in white pulp[Approved,Medium] |
| MIRNA:hsa-miR-149-5p | 0.0446745117525 | 0.6 | EEF1B2 MARCKSL1 HUWE1 | hsa-miR-149-5p |
| CORUM:6989 | 0.0499494897235 | 0.2 | PTMA | ProTalpha C9 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EEF1B2 | EIF5B | 0.628 | 0.68 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EEF1B2 | HUWE1 | 0.205 | 0.454 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EEF1B2 | MARCKSL1 | 0.04 | 0.268 | bioplex (MARCKSL1) bioplex_WMM youn_WMM gupta_WMM fraction |
| PTMA | EIF5B | 0.039 | 0.263 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| HUWE1 | EIF5B | 0.023 | 0.211 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| MARCKSL1 | EIF5B | 0.007 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PTMA | MARCKSL1 | 0.007 | 0.006 | bioplex_WMM gupta_WMM WMM_only |
| EEF1B2 | PTMA | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| HUWE1 | PTMA | 0.0 | 0.011 | bioplex_WMM youn_WMM fraction boldt_WMM |
| HUWE1 | MARCKSL1 | 0.0 | 0.001 | bioplex_WMM boldt youn_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_03940 has an average edge precision of 0.191 which is ranked 6297 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HUWE1 | HuMAP2_02837 HuMAP2_03940 |
| EEF1B2 | HuMAP2_01815 HuMAP2_03940 HuMAP2_04717 HuMAP2_05036 HuMAP2_05417 HuMAP2_06437 |
| MARCKSL1 | HuMAP2_03940 |
| EIF5B | HuMAP2_03940 HuMAP2_04717 HuMAP2_05036 HuMAP2_05417 |
| PTMA | HuMAP2_03257 HuMAP2_03940 |