hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03943
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SNRPB | Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') | UniProt NCBI |
| CMTR2 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) | UniProt NCBI |
| SNRPG | Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) | UniProt NCBI |
| SNRPE | Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2757 | 2.3628325482e-08 | 0.75 | SNRPE SNRPB SNRPG | SMN complex, U7 snRNA specific |
| CORUM:835 | 3.78034162849e-08 | 0.75 | SNRPE SNRPB SNRPG | 6S methyltransferase and RG-containing Sm proteins complex |
| CORUM:1142 | 5.67022676981e-08 | 0.75 | SNRPE SNRPB SNRPG | SMN complex |
| REAC:R-HSA-111367 | 1.61998317054e-07 | 0.75 | SNRPE SNRPB SNRPG | SLBP independent Processing of Histone Pre-mRNAs |
| REAC:R-HSA-77588 | 2.22736463084e-07 | 0.75 | SNRPE SNRPB SNRPG | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| CORUM:1068 | 3.07044439662e-07 | 0.75 | SNRPE SNRPB SNRPG | 12S U11 snRNP |
| CORUM:1143 | 3.07044439662e-07 | 0.75 | SNRPE SNRPB SNRPG | SMN complex |
| CORUM:1745 | 3.07044439662e-07 | 0.75 | SNRPE SNRPB SNRPG | SMN complex |
| CORUM:430 | 1.36522213713e-06 | 0.75 | SNRPE SNRPB SNRPG | 18S U11/U12 snRNP |
| CORUM:2755 | 3.34425419171e-06 | 0.75 | SNRPE SNRPB SNRPG | 17S U2 snRNP |
| REAC:R-HSA-75067 | 4.41854320762e-06 | 0.75 | SNRPE SNRPB SNRPG | Processing of Capped Intronless Pre-mRNA |
| GO:0005683 | 1.27120391093e-05 | 0.75 | SNRPE SNRPB SNRPG | U7 snRNP |
| CORUM:1743 | 1.50819606993e-05 | 0.5 | SNRPE SNRPG | (E.F.G) complex |
| REAC:R-HSA-194441 | 2.64063995051e-05 | 0.75 | SNRPE SNRPB SNRPG | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 2.64063995051e-05 | 0.75 | SNRPE SNRPB SNRPG | snRNP Assembly |
| REAC:R-HSA-72165 | 2.97715563398e-05 | 0.75 | SNRPE SNRPB SNRPG | mRNA Splicing - Minor Pathway |
| GO:0005687 | 4.35775472874e-05 | 0.75 | SNRPE SNRPB SNRPG | U4 snRNP |
| CORUM:1181 | 5.11748339077e-05 | 0.75 | SNRPE SNRPB SNRPG | C complex spliceosome |
| REAC:R-HSA-73856 | 5.34661380805e-05 | 0.75 | SNRPE SNRPB SNRPG | RNA Polymerase II Transcription Termination |
| WP:WP411 | 7.12553605747e-05 | 0.75 | SNRPE SNRPB SNRPG | mRNA Processing |
| CORUM:3118 | 7.53895486054e-05 | 0.5 | SNRPE SNRPB | SMN1-SIP1-SNRP complex |
| GO:0034709 | 7.98841194917e-05 | 0.75 | SNRPE SNRPB SNRPG | methylosome |
| KEGG:03040 | 9.56545898299e-05 | 0.75 | SNRPE SNRPB SNRPG | Spliceosome |
| GO:0005682 | 0.000203300410527 | 0.75 | SNRPE SNRPB SNRPG | U5 snRNP |
| GO:0034719 | 0.000246852342475 | 0.75 | SNRPE SNRPB SNRPG | SMN-Sm protein complex |
| GO:0005686 | 0.000296207880886 | 0.75 | SNRPE SNRPB SNRPG | U2 snRNP |
| CORUM:351 | 0.000300134552669 | 0.75 | SNRPE SNRPB SNRPG | Spliceosome |
| GO:0005685 | 0.000413778117181 | 0.75 | SNRPE SNRPB SNRPG | U1 snRNP |
| GO:0005689 | 0.000834605087859 | 0.75 | SNRPE SNRPB SNRPG | U12-type spliceosomal complex |
| GO:0008334 | 0.000834605087859 | 0.75 | SNRPE SNRPB SNRPG | histone mRNA metabolic process |
| REAC:R-HSA-72163 | 0.0012370641562 | 0.75 | SNRPE SNRPB SNRPG | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00141192686346 | 0.75 | SNRPE SNRPB SNRPG | mRNA Splicing |
| GO:0071007 | 0.00147288799354 | 0.75 | SNRPE SNRPB SNRPG | U2-type catalytic step 2 spliceosome |
| GO:0097526 | 0.00147288799354 | 0.75 | SNRPE SNRPB SNRPG | spliceosomal tri-snRNP complex |
| GO:0046540 | 0.00147288799354 | 0.75 | SNRPE SNRPB SNRPG | U4/U6 x U5 tri-snRNP complex |
| GO:0006369 | 0.00237379826551 | 0.75 | SNRPE SNRPB SNRPG | termination of RNA polymerase II transcription |
| REAC:R-HSA-72203 | 0.00285014014969 | 0.75 | SNRPE SNRPB SNRPG | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000387 | 0.00305917975424 | 0.75 | SNRPE SNRPB SNRPG | spliceosomal snRNP assembly |
| GO:0071005 | 0.00710332146687 | 0.75 | SNRPE SNRPB SNRPG | U2-type precatalytic spliceosome |
| GO:0071011 | 0.00754689803038 | 0.75 | SNRPE SNRPB SNRPG | precatalytic spliceosome |
| GO:0097525 | 0.0106004966657 | 0.75 | SNRPE SNRPB SNRPG | spliceosomal snRNP complex |
| GO:0030532 | 0.0143823911437 | 0.75 | SNRPE SNRPB SNRPG | small nuclear ribonucleoprotein complex |
| GO:0006353 | 0.0225145500348 | 0.75 | SNRPE SNRPB SNRPG | DNA-templated transcription, termination |
| GO:0120114 | 0.023464682987 | 0.75 | SNRPE SNRPB SNRPG | Sm-like protein family complex |
| GO:0006397 | 0.0251226492241 | 1.0 | SNRPE CMTR2 SNRPB SNRPG | mRNA processing |
| GO:0071013 | 0.03324351702 | 0.75 | SNRPE SNRPB SNRPG | catalytic step 2 spliceosome |
| GO:0005684 | 0.0439367749778 | 0.75 | SNRPE SNRPB SNRPG | U2-type spliceosomal complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SNRPB | SNRPG | 0.738 | 0.738 | hein_WMM bioplex (SNRPG) bioplex_WMM boldt youn_WMM boldt_WMM |
| SNRPG | CMTR2 | 0.588 | 0.662 | bioplex (SNRPG) bioplex_WMM |
| SNRPE | SNRPG | 0.584 | 0.664 | bioplex (SNRPE,SNRPG) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SNRPB | SNRPE | 0.21 | 0.457 | bioplex (SNRPE) bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM |
| SNRPE | CMTR2 | 0.164 | 0.42 | bioplex (SNRPE) bioplex_WMM |
| SNRPB | CMTR2 | 0.012 | 0.15 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03943 has an average edge precision of 0.515 which is ranked 2415 out of all 6965 complexes.
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