hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03955
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BAK1 | Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) | UniProt NCBI |
| MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | UniProt NCBI |
| BBC3 | Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5823 | 3.35600554376e-06 | 0.666666666667 | BAK1 MCL1 | MCL1-BAK1 complex |
| WP:WP254 | 4.00606535768e-06 | 1.0 | BBC3 BAK1 MCL1 | Apoptosis |
| WP:WP1772 | 5.49549000446e-06 | 1.0 | BBC3 BAK1 MCL1 | Apoptosis Modulation and Signaling |
| KEGG:04210 | 9.55549752694e-06 | 1.0 | BBC3 BAK1 MCL1 | Apoptosis |
| WP:WP3872 | 0.000182100906477 | 0.666666666667 | BAK1 MCL1 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| KEGG:04215 | 0.00019456526656 | 0.666666666667 | BAK1 BBC3 | Apoptosis - multiple species |
| WP:WP3614 | 0.000505754093136 | 0.666666666667 | BAK1 MCL1 | Photodynamic therapy-induced HIF-1 survival signaling |
| WP:WP3611 | 0.00103480501892 | 0.666666666667 | BAK1 MCL1 | Photodynamic therapy-induced AP-1 survival signaling. |
| KEGG:01524 | 0.0011410864499 | 0.666666666667 | BAK1 BBC3 | Platinum drug resistance |
| KEGG:05210 | 0.00148194300046 | 0.666666666667 | BAK1 BBC3 | Colorectal cancer |
| WP:WP4216 | 0.00237624614213 | 0.666666666667 | BAK1 BBC3 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05162 | 0.00361949387372 | 0.666666666667 | BAK1 BBC3 | Measles |
| WP:WP710 | 0.00511400973198 | 0.666666666667 | BAK1 BBC3 | DNA Damage Response (only ATM dependent) |
| KEGG:05206 | 0.00544616782939 | 0.666666666667 | BAK1 MCL1 | MicroRNAs in cancer |
| MIRNA:hsa-miR-125b-5p | 0.00685635788537 | 1.0 | BBC3 BAK1 MCL1 | hsa-miR-125b-5p |
| REAC:R-HSA-109606 | 0.00818423736949 | 0.666666666667 | BAK1 BBC3 | Intrinsic Pathway for Apoptosis |
| WP:WP4396 | 0.00888189132931 | 0.666666666667 | BAK1 BBC3 | Nonalcoholic fatty liver disease |
| MIRNA:hsa-miR-876-3p | 0.0178183335155 | 0.666666666667 | MCL1 BBC3 | hsa-miR-876-3p |
| GO:2001235 | 0.0185411572066 | 1.0 | BBC3 BAK1 MCL1 | positive regulation of apoptotic signaling pathway |
| GO:0097136 | 0.020283420769 | 0.666666666667 | BAK1 MCL1 | Bcl-2 family protein complex |
| GO:0005741 | 0.0268132763851 | 1.0 | BBC3 BAK1 MCL1 | mitochondrial outer membrane |
| WP:WP4399 | 0.0285649389616 | 0.333333333333 | MCL1 | MicroRNA network associated with chronic lymphocytic leukemia |
| GO:0031968 | 0.0340260876928 | 1.0 | BBC3 BAK1 MCL1 | organelle outer membrane |
| GO:0019867 | 0.0348113051011 | 1.0 | BBC3 BAK1 MCL1 | outer membrane |
| GO:1903896 | 0.0378589948753 | 0.666666666667 | BAK1 BBC3 | positive regulation of IRE1-mediated unfolded protein response |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | BAK1 BBC3 | Pathways in cancer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAK1 | MCL1 | 0.998 | 0.939 | bioplex (MCL1) |
| MCL1 | BBC3 | 0.628 | 0.68 | bioplex (MCL1) |
| BAK1 | BBC3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03955 has an average edge precision of 0.574 which is ranked 2057 out of all 6965 complexes.
Related Complexes