hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03956
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYO18A | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | UniProt NCBI |
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | UniProt NCBI |
| ACTRT1 | Actin-related protein T1 (ARP-T1) | UniProt NCBI |
| PLEC | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | UniProt NCBI |
| MYH10 | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | UniProt NCBI |
| MYH9 | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-416572 | 1.10418282249e-08 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5625900 | 1.10418282249e-08 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 1.10418282249e-08 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5627123 | 1.38000589566e-08 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 2.52095754391e-08 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 4.25410234044e-08 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | EPHA-mediated growth cone collapse |
| REAC:R-HSA-373755 | 1.28820166004e-06 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | Semaphorin interactions |
| REAC:R-HSA-2682334 | 5.98438062164e-06 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | EPH-Ephrin signaling |
| REAC:R-HSA-5625740 | 8.21877381145e-06 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | RHO GTPases activate PKNs |
| KEGG:04530 | 1.54550028729e-05 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | Tight junction |
| CORUM:486 | 0.000150938581911 | 0.285714285714 | MYL6 MYH9 | WIP-WASp-actin-myosin-IIa complex |
| GO:0030898 | 0.000266683990267 | 0.428571428571 | MYL6 MYH10 MYH9 | actin-dependent ATPase activity |
| REAC:R-HSA-195258 | 0.00101240038307 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | RHO GTPase Effectors |
| KEGG:04810 | 0.00344277959012 | 0.428571428571 | MYL12B MYH10 MYH9 | Regulation of actin cytoskeleton |
| REAC:R-HSA-194315 | 0.00374244313656 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | Signaling by Rho GTPases |
| REAC:R-HSA-422475 | 0.00749530493622 | 0.571428571429 | MYL12B MYH9 MYH10 MYL6 | Axon guidance |
| GO:0043531 | 0.00925268005943 | 0.428571428571 | MYH9 MYH10 MYO18A | ADP binding |
| REAC:R-HSA-445355 | 0.0166025057177 | 0.285714285714 | MYL12B MYL6 | Smooth Muscle Contraction |
| GO:0016459 | 0.0172381420268 | 0.428571428571 | MYL6 MYH10 MYH9 | myosin complex |
| GO:0097513 | 0.0283955176165 | 0.285714285714 | MYH9 MYH10 | myosin II filament |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYH9 | MYH10 | 0.981 | 0.897 | hein_WMM bioplex (MYH9) bioplex_WMM boldt youn_WMM hein (MYH10,MYH9) gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYO18A | 0.98 | 0.896 | hein_WMM bioplex (MYL6) bioplex_WMM hein (MYO18A) |
| MYL12B | MYL6 | 0.875 | 0.809 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYL12B) gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYH9 | 0.743 | 0.739 | hein_WMM bioplex (MYH9,MYL6) bioplex_WMM boldt youn_WMM hein (MYH9) gupta_WMM boldt_WMM treiber_WMM |
| MYL12B | MYH9 | 0.604 | 0.672 | hein_WMM bioplex (MYH9) bioplex_WMM boldt youn_WMM hein (MYH9,MYL12B) gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYH10 | 0.12 | 0.392 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYH10) gupta_WMM boldt_WMM treiber_WMM |
| MYL12B | MYO18A | 0.102 | 0.364 | hein_WMM bioplex_WMM hein (MYL12B,MYO18A) |
| MYH9 | ACTRT1 | 0.052 | 0.304 | hein_WMM hein (MYH9) |
| MYH9 | PLEC | 0.041 | 0.269 | hein_WMM bioplex_WMM youn_WMM hein (MYH9) boldt_WMM treiber_WMM |
| MYO18A | MYH9 | 0.028 | 0.23 | hein_WMM bioplex_WMM hein (MYH9,MYO18A) treiber_WMM |
| MYL12B | MYH10 | 0.02 | 0.186 | hein_WMM bioplex_WMM boldt youn_WMM hein (MYH10) gupta_WMM boldt_WMM |
| ACTRT1 | PLEC | 0.007 | 0.006 | hein_WMM WMM_only |
| ACTRT1 | MYH10 | 0.007 | 0.001 | hein_WMM WMM_only |
| MYL12B | ACTRT1 | 0.007 | 0.003 | hein_WMM WMM_only |
| MYL6 | ACTRT1 | 0.007 | 0.008 | hein_WMM WMM_only |
| MYL12B | PLEC | 0.007 | 0.002 | hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM |
| MYO18A | ACTRT1 | 0.006 | 0.006 | hein_WMM WMM_only |
| MYL6 | PLEC | 0.006 | 0.007 | hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM treiber_WMM |
| MYO18A | PLEC | 0.006 | 0.002 | hein_WMM hein (MYO18A) treiber_WMM |
| MYH10 | PLEC | 0.005 | 0.01 | hein_WMM youn_WMM WMM_only boldt_WMM treiber_WMM |
| MYO18A | MYH10 | 0.005 | 0.009 | hein_WMM bioplex_WMM hein (MYH10) treiber_WMM |
Images
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Complex HuMAP2_03956 has an average edge precision of 0.277 which is ranked 4929 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYO18A | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| MYL12B | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| ACTRT1 | HuMAP2_02178 HuMAP2_03956 |
| PLEC | HuMAP2_03956 HuMAP2_04141 |
| MYH10 | HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_04152 |
| MYL6 | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04152 HuMAP2_04655 |
| MYH9 | HuMAP2_02160 HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_06706 |