hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03969

Confidence: Medium

Genename	Protein Name	Links
UMAD1	UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand)	UniProt NCBI
MVB12A	Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)	UniProt NCBI
VPS37C	Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)	UniProt NCBI
UBAP1	Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein)	UniProt NCBI
VPS37A	Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1)	UniProt NCBI
VPS28	Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)	UniProt NCBI
VPS37B	Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)	UniProt NCBI
TSG101	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-174495	1.51057732359e-19	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Synthesis And Processing Of GAG, GAGPOL Polyproteins
REAC:R-HSA-174490	1.51057732359e-19	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Membrane binding and targetting of GAG proteins
GO:0000813	4.46966480611e-19	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	ESCRT I complex
REAC:R-HSA-175474	5.03466559592e-19	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Assembly Of The HIV Virion
REAC:R-HSA-9615710	3.90563106103e-17	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Microautophagy
REAC:R-HSA-162588	5.20720164407e-17	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Budding and maturation of HIV virion
REAC:R-HSA-917729	1.15623710884e-16	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Endosomal Sorting Complex Required For Transport (ESCRT)
GO:0043162	9.61845477129e-16	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0036452	5.9626307868e-15	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	ESCRT complex
REAC:R-HSA-9612973	8.67517392625e-13	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Autophagy
GO:0075733	2.19301728846e-12	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	intracellular transport of virus
GO:0046794	3.2732826498e-12	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	transport of virus
GO:0039702	5.00715728072e-12	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	viral budding via host ESCRT complex
REAC:R-HSA-162599	5.43699862893e-12	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	1.05885389445e-11	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	HIV Life Cycle
GO:0044766	1.33480579567e-11	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	multi-organism transport
GO:1902579	1.33480579567e-11	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	multi-organism localization
GO:0046755	1.63341960744e-11	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	viral budding
GO:0036258	5.47331906216e-11	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	multivesicular body assembly
GO:0036257	6.7861330958e-11	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	multivesicular body organization
REAC:R-HSA-162906	2.15093880142e-10	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	HIV Infection
GO:0019068	3.00431142893e-10	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	virion assembly
CORUM:1192	4.70911134935e-09	0.375	TSG101 VPS28 VPS37C	ESCRT-I complex
CORUM:1863	4.70911134935e-09	0.375	VPS37B VPS28 TSG101	TSG101-VPS37B-VPS28 complex
REAC:R-HSA-5663205	6.07911979864e-09	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Infectious disease
GO:0007032	1.20303755307e-08	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	endosome organization
KEGG:04144	1.7115303656e-08	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	Endocytosis
GO:0016197	2.80378800322e-08	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	endosomal transport
GO:0019058	9.05914550983e-08	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	viral life cycle
REAC:R-HSA-199991	1.81934752579e-07	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Membrane Trafficking
REAC:R-HSA-5653656	2.64780086347e-07	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Vesicle-mediated transport
GO:0010008	2.67053120963e-07	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	endosome membrane
GO:0044440	6.80682745504e-07	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	endosomal part
REAC:R-HSA-1643685	5.59548960867e-06	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	Disease
GO:0016032	6.74344260206e-06	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	viral process
GO:0044403	1.32616080196e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	symbiotic process
GO:0006511	1.42637039189e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	ubiquitin-dependent protein catabolic process
GO:0019941	1.51113867297e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	modification-dependent protein catabolic process
GO:0043632	1.76683488799e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	modification-dependent macromolecule catabolic process
GO:0044419	1.94812476105e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	interspecies interaction between organisms
GO:0016236	3.30913875777e-05	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	macroautophagy
GO:0016050	4.36144788143e-05	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	vesicle organization
GO:0051603	4.59931208891e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	proteolysis involved in cellular protein catabolic process
GO:0007034	6.04437816709e-05	0.625	VPS37B MVB12A VPS37A VPS28 VPS37C	vacuolar transport
GO:0005768	7.13246416286e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	endosome
GO:0044257	8.55147748663e-05	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	cellular protein catabolic process
GO:0072666	0.000154861828642	0.5	VPS37B VPS37A VPS28 VPS37C	establishment of protein localization to vacuole
GO:0010256	0.000161059380622	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	endomembrane system organization
GO:0030163	0.000250787237937	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	protein catabolic process
GO:0006914	0.000448581094574	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	autophagy
GO:0061919	0.000448581094574	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	process utilizing autophagic mechanism
GO:0072665	0.000534279096056	0.5	VPS37B VPS37A VPS28 VPS37C	protein localization to vacuole
GO:0098796	0.000833989390095	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	membrane protein complex
GO:0043130	0.00145578706246	0.5	TSG101 MVB12A VPS28 UBAP1	ubiquitin binding
GO:0044265	0.00181145261579	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	cellular macromolecule catabolic process
GO:1901565	0.00243447233413	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	organonitrogen compound catabolic process
GO:0044433	0.00302439749634	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	cytoplasmic vesicle part
GO:0032182	0.00373379969889	0.5	TSG101 MVB12A VPS28 UBAP1	ubiquitin-like protein binding
GO:0098805	0.00437978187143	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	whole membrane
GO:0009057	0.00551287161027	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	macromolecule catabolic process
GO:0006508	0.00952033788181	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	proteolysis
GO:0070925	0.0111731156143	0.75	VPS37B VPS28 MVB12A VPS37C VPS37A TSG101	organelle assembly
GO:0098588	0.0174309629791	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	bounding membrane of organelle
HPA:036010_23	0.0207174598117	0.5	TSG101 UMAD1 MVB12A VPS37C	prostate; glandular cells[Approved,High]
GO:0006623	0.0250420956031	0.375	VPS37B VPS37A VPS37C	protein targeting to vacuole
GO:0046907	0.0266810279817	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	intracellular transport
GO:0051704	0.0356536253492	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	multi-organism process
GO:1903774	0.0378589948753	0.25	VPS37B TSG101	positive regulation of viral budding via host ESCRT complex
GO:0016192	0.0468723721447	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	vesicle-mediated transport
GO:0031410	0.0485739380915	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	cytoplasmic vesicle
GO:0097708	0.0487902909386	0.875	VPS37B VPS28 UBAP1 VPS37C MVB12A VPS37A TSG101	intracellular vesicle

Edges

Protein 1	Protein 2	Score	Precision	Evidence
VPS37B	VPS28	1.0	0.949	hein_WMM bioplex (VPS28) bioplex_WMM Guru youn_WMM hein (VPS28) Malo fraction
VPS28	VPS37A	1.0	0.949	hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28)
MVB12A	VPS28	1.0	0.949	hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28) Malo fraction
TSG101	VPS28	1.0	0.949	hein_WMM bioplex (VPS28) bioplex_WMM Guru youn_WMM hein (TSG101,VPS28) Malo gupta_WMM fraction
VPS37B	TSG101	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) Malo fraction
TSG101	UBAP1	1.0	0.949	hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM hein (TSG101) Malo fraction
VPS28	UBAP1	1.0	0.949	hein_WMM bioplex (UBAP1,VPS28) bioplex_WMM hein (VPS28)
MVB12A	TSG101	0.996	0.927	hein_WMM bioplex_WMM hein (TSG101) Malo fraction
TSG101	VPS37C	0.987	0.902	hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) fraction
UBAP1	VPS37A	0.919	0.841	hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM
MVB12A	VPS37B	0.509	0.629	hein_WMM bioplex_WMM Malo fraction
VPS37C	VPS28	0.404	0.564	hein_WMM bioplex (VPS28) bioplex_WMM youn_WMM hein (VPS28)
TSG101	VPS37A	0.211	0.459	hein_WMM bioplex_WMM youn_WMM hein (TSG101)
VPS37B	UBAP1	0.152	0.409	hein_WMM bioplex (UBAP1) bioplex_WMM
VPS28	UMAD1	0.086	0.352	hein_WMM hein (VPS28)
VPS37B	VPS37A	0.015	0.14	hein_WMM bioplex_WMM youn_WMM WMM_only
MVB12A	VPS37C	0.012	0.147	hein_WMM bioplex_WMM WMM_only
MVB12A	UBAP1	0.01	0.105	hein_WMM bioplex_WMM WMM_only
MVB12A	VPS37A	0.009	0.11	hein_WMM bioplex_WMM WMM_only
TSG101	UMAD1	0.009	0.107	hein_WMM WMM_only
VPS37C	UBAP1	0.009	0.107	hein_WMM bioplex_WMM WMM_only
VPS37B	VPS37C	0.009	0.101	hein_WMM bioplex_WMM youn_WMM WMM_only
VPS37C	VPS37A	0.009	0.09	hein_WMM bioplex_WMM WMM_only
UBAP1	UMAD1	0.007	0.002	hein_WMM WMM_only
VPS37A	UMAD1	0.007	0.002	hein_WMM WMM_only
VPS37B	UMAD1	0.007	0.002	hein_WMM WMM_only
MVB12A	UMAD1	0.007	0.01	hein_WMM WMM_only
VPS37C	UMAD1	0.007	0.006	hein_WMM WMM_only

Images

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Complex HuMAP2_03969 has an average edge precision of 0.452 which is ranked 2865 out of all 6965 complexes.

Related Complexes

Genename	Complexes
UMAD1	HuMAP2_02057 HuMAP2_03969
MVB12A	HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_05381 HuMAP2_05909 HuMAP2_06430
VPS37C	HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 HuMAP2_06935
UBAP1	HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430
VPS37A	HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430
VPS28	HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430
VPS37B	HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430
TSG101	HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03969