hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03973
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | UniProt NCBI |
| TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] | UniProt NCBI |
| SCAI | Protein SCAI (Suppressor of cancer cell invasion protein) | UniProt NCBI |
| TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | UniProt NCBI |
| AHDC1 | AT-hook DNA-binding motif-containing protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6347 | 1.35119464053e-08 | 0.6 | TRADD TNFRSF1A TNF | TNF-R1 signaling complex |
| WP:WP2513 | 1.47866495656e-07 | 0.6 | TRADD TNFRSF1A TNF | Nanoparticle triggered regulated necrosis |
| REAC:R-HSA-5357786 | 5.97663979449e-07 | 0.6 | TRADD TNFRSF1A TNF | TNFR1-induced proapoptotic signaling |
| CORUM:6344 | 6.14174359209e-07 | 0.6 | TRADD TNFRSF1A TNF | TNF-R1-associated signaling complex |
| REAC:R-HSA-5357956 | 9.90965664735e-06 | 0.6 | TRADD TNFRSF1A TNF | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-5357905 | 1.10096191184e-05 | 0.6 | TRADD TNFRSF1A TNF | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 2.67648652633e-05 | 0.6 | TRADD TNFRSF1A TNF | TNF signaling |
| KEGG:04920 | 3.58157342459e-05 | 0.6 | TRADD TNFRSF1A TNF | Adipocytokine signaling pathway |
| CORUM:5531 | 4.0241279111e-05 | 0.4 | TRADD TNFRSF1A | Tumor necrosis factor receptor 1 signaling complex |
| WP:WP254 | 4.15466421509e-05 | 0.6 | TRADD TNFRSF1A TNF | Apoptosis |
| GO:0071550 | 5.0832789986e-05 | 0.6 | TRADD TNFRSF1A TNF | death-inducing signaling complex assembly |
| KEGG:04064 | 6.78759182453e-05 | 0.6 | TRADD TNFRSF1A TNF | NF-kappa B signaling pathway |
| WP:WP231 | 7.31920604822e-05 | 0.6 | TRADD TNFRSF1A TNF | TNF alpha Signaling Pathway |
| KEGG:04668 | 0.000111224532588 | 0.6 | TRADD TNFRSF1A TNF | TNF signaling pathway |
| KEGG:04071 | 0.000179646697347 | 0.6 | TRADD TNFRSF1A TNF | Sphingolipid signaling pathway |
| REAC:R-HSA-5626978 | 0.000202356855584 | 0.4 | TNF TNFRSF1A | TNFR1-mediated ceramide production |
| KEGG:04210 | 0.000271467766564 | 0.6 | TRADD TNFRSF1A TNF | Apoptosis |
| KEGG:05160 | 0.000349924863199 | 0.6 | TRADD TNFRSF1A TNF | Hepatitis C |
| KEGG:05164 | 0.000451232943381 | 0.6 | TRADD TNFRSF1A TNF | Influenza A |
| KEGG:05152 | 0.00046980759615 | 0.6 | TRADD TNFRSF1A TNF | Tuberculosis |
| KEGG:04217 | 0.00048888248268 | 0.6 | TRADD TNFRSF1A TNF | Necroptosis |
| WP:WP262 | 0.000699493021643 | 0.4 | TRADD TNF | EBV LMP1 signaling |
| KEGG:05130 | 0.000772172961031 | 0.6 | TRADD TNFRSF1A TNF | Pathogenic Escherichia coli infection |
| REAC:R-HSA-73887 | 0.000874143100407 | 0.6 | TRADD TNFRSF1A TNF | Death Receptor Signalling |
| KEGG:05170 | 0.00109699385517 | 0.6 | TRADD TNFRSF1A TNF | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.00114726739179 | 0.6 | TRADD TNFRSF1A TNF | Human cytomegalovirus infection |
| WP:WP3617 | 0.00144719807027 | 0.4 | TNF TNFRSF1A | Photodynamic therapy-induced NF-kB survival signaling |
| KEGG:04010 | 0.00232977147301 | 0.6 | TRADD TNFRSF1A TNF | MAPK signaling pathway |
| WP:WP2447 | 0.00233629086428 | 0.4 | TNF TNFRSF1A | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04061 | 0.00269260965903 | 0.4 | TNF TNFRSF1A | Viral protein interaction with cytokine and cytokine receptor |
| REAC:R-HSA-6783783 | 0.00340529843133 | 0.4 | TNF TNFRSF1A | Interleukin-10 signaling |
| WP:WP3611 | 0.00358815839426 | 0.4 | TNF TNFRSF1A | Photodynamic therapy-induced AP-1 survival signaling. |
| WP:WP2795 | 0.00374366167833 | 0.4 | TNF TNFRSF1A | Cardiac Hypertrophic Response |
| KEGG:05165 | 0.00420236199627 | 0.6 | TRADD TNFRSF1A TNF | Human papillomavirus infection |
| WP:WP3865 | 0.00474544100801 | 0.4 | TRADD TNF | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:05014 | 0.00543834659805 | 0.4 | TNF TNFRSF1A | Amyotrophic lateral sclerosis (ALS) |
| WP:WP4341 | 0.00646864373199 | 0.4 | TNF TNFRSF1A | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| KEGG:05168 | 0.00749393790538 | 0.6 | TRADD TNFRSF1A TNF | Herpes simplex virus 1 infection |
| KEGG:04622 | 0.00858395707223 | 0.4 | TRADD TNF | RIG-I-like receptor signaling pathway |
| KEGG:04657 | 0.0102745641273 | 0.4 | TRADD TNF | IL-17 signaling pathway |
| WP:WP2059 | 0.0104424923561 | 0.4 | TNF TNFRSF1A | Alzheimers Disease |
| WP:WP1772 | 0.0107054175474 | 0.4 | TRADD TNFRSF1A | Apoptosis Modulation and Signaling |
| GO:0010803 | 0.0146610377831 | 0.6 | TRADD TNFRSF1A TNF | regulation of tumor necrosis factor-mediated signaling pathway |
| KEGG:05142 | 0.0162467151192 | 0.4 | TNF TNFRSF1A | Chagas disease (American trypanosomiasis) |
| KEGG:05145 | 0.0185363159266 | 0.4 | TNF TNFRSF1A | Toxoplasmosis |
| KEGG:04931 | 0.0218205669165 | 0.4 | TNF TNFRSF1A | Insulin resistance |
| KEGG:04380 | 0.0222496587654 | 0.4 | TNF TNFRSF1A | Osteoclast differentiation |
| GO:0008625 | 0.0264291737868 | 0.6 | TRADD TNFRSF1A TNF | extrinsic apoptotic signaling pathway via death domain receptors |
| WP:WP4396 | 0.0305499086042 | 0.4 | TNF TNFRSF1A | Nonalcoholic fatty liver disease |
| KEGG:05418 | 0.0327287628992 | 0.4 | TNF TNFRSF1A | Fluid shear stress and atherosclerosis |
| KEGG:04932 | 0.0370300962025 | 0.4 | TNF TNFRSF1A | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04150 | 0.0433693821301 | 0.4 | TNF TNFRSF1A | mTOR signaling pathway |
| GO:0050729 | 0.0472676873043 | 0.6 | TRADD TNFRSF1A TNF | positive regulation of inflammatory response |
| REAC:R-HSA-5668541 | 0.0476518941102 | 0.4 | TNF TNFRSF1A | TNFR2 non-canonical NF-kB pathway |
| KEGG:05010 | 0.0495576477539 | 0.4 | TNF TNFRSF1A | Alzheimer disease |
| WP:WP3297 | 0.0497141369515 | 0.2 | TNF | EV release from cardiac cells and their functional effects |
| CORUM:5540 | 0.0499494897235 | 0.2 | TRADD | TRAF2-TRADD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNFRSF1A | TRADD | 0.702 | 0.723 | bioplex (TNFRSF1A) bioplex_WMM |
| TNFRSF1A | TNF | 0.352 | 0.539 | bioplex (TNF,TNFRSF1A) bioplex_WMM |
| TNFRSF1A | SCAI | 0.175 | 0.435 | bioplex (TNFRSF1A) bioplex_WMM |
| SCAI | AHDC1 | 0.046 | 0.293 | hein_WMM hein (SCAI) |
| TRADD | TNF | 0.008 | 0.085 | bioplex_WMM WMM_only |
| TRADD | SCAI | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SCAI | TNF | 0.008 | 0.067 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03973 has an average edge precision of 0.316 which is ranked 4397 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNF | HuMAP2_03973 |
| TNFRSF1A | HuMAP2_03038 HuMAP2_03973 |
| SCAI | HuMAP2_03552 HuMAP2_03973 HuMAP2_06177 |
| TRADD | HuMAP2_03038 HuMAP2_03973 |
| AHDC1 | HuMAP2_03552 HuMAP2_03973 HuMAP2_05792 HuMAP2_06177 |