hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03977
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBPL1 | TATA box-binding protein-like protein 1 (TBP-like protein 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) | UniProt NCBI |
| TBP | TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) | UniProt NCBI |
| CUEDC2 | CUE domain-containing protein 2 | UniProt NCBI |
| GTF2A1 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | UniProt NCBI |
| GTF2A2 | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03022 | 1.29762871113e-08 | 0.8 | TBP GTF2A1 TBPL1 GTF2A2 | Basal transcription factors |
| CORUM:492 | 6.14174359209e-07 | 0.6 | GTF2A1 GTF2A2 TBP | DA complex |
| CORUM:493 | 7.55830716665e-07 | 0.6 | GTF2A1 GTF2A2 TBP | DAB complex |
| GO:0005672 | 9.08185760231e-07 | 0.6 | GTF2A1 GTF2A2 TBP | transcription factor TFIIA complex |
| KEGG:05203 | 5.79761916632e-06 | 0.8 | TBP GTF2A1 TBPL1 GTF2A2 | Viral carcinogenesis |
| CORUM:490 | 6.70868171695e-06 | 0.4 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:489 | 6.70868171695e-06 | 0.4 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:1221 | 2.0123342217e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA-TRF2 complex |
| REAC:R-HSA-73779 | 4.3895322704e-05 | 0.6 | GTF2A1 GTF2A2 TBP | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-76042 | 4.3895322704e-05 | 0.6 | GTF2A1 GTF2A2 TBP | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-75953 | 4.3895322704e-05 | 0.6 | GTF2A1 GTF2A2 TBP | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-167161 | 4.3895322704e-05 | 0.6 | GTF2A1 GTF2A2 TBP | HIV Transcription Initiation |
| REAC:R-HSA-73776 | 4.3895322704e-05 | 0.6 | GTF2A1 GTF2A2 TBP | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-167162 | 4.3895322704e-05 | 0.6 | GTF2A1 GTF2A2 TBP | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-167172 | 0.000154348632803 | 0.6 | GTF2A1 GTF2A2 TBP | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.000175005907139 | 0.6 | GTF2A1 GTF2A2 TBP | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.000238892911782 | 0.6 | GTF2A1 GTF2A2 TBP | RNA Polymerase II Pre-transcription Events |
| GO:0016251 | 0.000259479548289 | 0.6 | GTF2A1 GTF2A2 TBP | RNA polymerase II general transcription initiation factor activity |
| GO:0140223 | 0.000739960245213 | 0.6 | GTF2A1 GTF2A2 TBP | general transcription initiation factor activity |
| REAC:R-HSA-162599 | 0.00102865345201 | 0.6 | GTF2A1 GTF2A2 TBP | Late Phase of HIV Life Cycle |
| REAC:R-HSA-9018519 | 0.00122625830858 | 0.6 | GTF2A1 GTF2A2 TBP | Estrogen-dependent gene expression |
| REAC:R-HSA-162587 | 0.00136170542712 | 0.6 | GTF2A1 GTF2A2 TBP | HIV Life Cycle |
| WP:WP405 | 0.00272401961957 | 0.4 | GTF2A2 TBP | Eukaryotic Transcription Initiation |
| REAC:R-HSA-8939211 | 0.00371466203946 | 0.6 | GTF2A1 GTF2A2 TBP | ESR-mediated signaling |
| REAC:R-HSA-162906 | 0.00484900153486 | 0.6 | GTF2A1 GTF2A2 TBP | HIV Infection |
| GO:0005669 | 0.00541762673764 | 0.6 | GTF2A1 GTF2A2 TBP | transcription factor TFIID complex |
| GO:0140296 | 0.00541762673764 | 0.6 | GTF2A1 GTF2A2 TBP | general transcription initiation factor binding |
| REAC:R-HSA-9006931 | 0.00634577840696 | 0.6 | GTF2A1 GTF2A2 TBP | Signaling by Nuclear Receptors |
| REAC:R-HSA-5663205 | 0.0198891654246 | 0.6 | GTF2A1 GTF2A2 TBP | Infectious disease |
| GO:0005667 | 0.0200611173853 | 0.8 | TBP GTF2A1 TBPL1 GTF2A2 | transcription factor complex |
| CORUM:721 | 0.0249780992026 | 0.2 | TBP | PU.1-TBP complex |
| GO:0042795 | 0.0493791608738 | 0.6 | GTF2A1 GTF2A2 TBP | snRNA transcription by RNA polymerase II |
| CORUM:629 | 0.0499494897235 | 0.2 | TBPL1 | BLM-TRF2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TBPL1 | GTF2A1 | 0.998 | 0.944 | bioplex (GTF2A1) bioplex_WMM youn_WMM gupta_WMM |
| GTF2A2 | GTF2A1 | 0.803 | 0.767 | bioplex (GTF2A1) bioplex_WMM youn_WMM gupta_WMM fraction |
| GTF2A1 | TBP | 0.225 | 0.466 | bioplex (GTF2A1) bioplex_WMM gupta_WMM |
| GTF2A2 | CUEDC2 | 0.079 | 0.351 | bioplex (CUEDC2) bioplex_WMM youn_WMM |
| CUEDC2 | TBP | 0.026 | 0.215 | bioplex (CUEDC2) bioplex_WMM |
| GTF2A2 | TBPL1 | 0.01 | 0.098 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GTF2A2 | TBP | 0.009 | 0.09 | bioplex_WMM gupta_WMM WMM_only |
| TBPL1 | TBP | 0.008 | 0.032 | bioplex_WMM gupta_WMM WMM_only |
| CUEDC2 | TBPL1 | 0.007 | 0.009 | youn_WMM gupta_WMM WMM_only |
| CUEDC2 | GTF2A1 | 0.0 | 0.01 | bioplex (CUEDC2) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_03977 has an average edge precision of 0.298 which is ranked 4623 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TBPL1 | HuMAP2_03120 HuMAP2_03257 HuMAP2_03977 |
| TBP | HuMAP2_03257 HuMAP2_03977 |
| CUEDC2 | HuMAP2_02668 HuMAP2_03977 HuMAP2_04374 |
| GTF2A1 | HuMAP2_03120 HuMAP2_03257 HuMAP2_03977 |
| GTF2A2 | HuMAP2_02668 HuMAP2_03120 HuMAP2_03257 HuMAP2_03977 |