hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03982
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| REXO2 | Oligoribonuclease, mitochondrial (EC 3.1.-.-) (RNA exonuclease 2 homolog) (Small fragment nuclease) | UniProt NCBI |
| GGT1 | Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain] | UniProt NCBI |
| GAA | Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase] | UniProt NCBI |
| GLA | Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) | UniProt NCBI |
| ECE1 | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00052 | 0.000701711284527 | 0.5 | GAA GLA | Galactose metabolism |
| KEGG:04142 | 0.0136880283161 | 0.5 | GAA GLA | Lysosome |
| HP:0011675 | 0.0164047655465 | 0.75 | ECE1 GAA GLA | Arrhythmia |
| HP:0030956 | 0.0210685962912 | 0.75 | ECE1 GAA GLA | Abnormality of cardiovascular system electrophysiology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GAA | ECE1 | 0.146 | 0.409 | bioplex_WMM fraction |
| GAA | GLA | 0.144 | 0.406 | bioplex (GAA) bioplex_WMM fraction |
| GAA | REXO2 | 0.08 | 0.352 | bioplex_WMM fraction |
| GGT1 | GAA | 0.051 | 0.296 | bioplex (GGT1) fraction |
| REXO2 | GLA | 0.007 | 0.003 | bioplex_WMM WMM_only |
| GGT1 | GLA | 0.007 | 0.006 | bioplex (GGT1) |
| GGT1 | REXO2 | 0.006 | 0.011 | bioplex (GGT1) bioplex_WMM |
| ECE1 | REXO2 | 0.003 | 0.016 | fraction |
| ECE1 | GLA | 0.0 | 0.001 | bioplex_WMM fraction |
Images
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Complex HuMAP2_03982 has an average edge precision of 0.167 which is ranked 6559 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| REXO2 | HuMAP2_03982 HuMAP2_04227 HuMAP2_06684 |
| GGT1 | HuMAP2_01129 HuMAP2_03982 |
| GAA | HuMAP2_01176 HuMAP2_01672 HuMAP2_02517 HuMAP2_03982 HuMAP2_04227 HuMAP2_06251 HuMAP2_06263 HuMAP2_06518 HuMAP2_06684 |
| GLA | HuMAP2_03982 HuMAP2_05233 |
| ECE1 | HuMAP2_03429 HuMAP2_03982 HuMAP2_04227 HuMAP2_06684 |