hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03989

Confidence: Medium

Genename	Protein Name	Links
CALCOCO1	Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)	UniProt NCBI
REXO1	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1)	UniProt NCBI
PER1	Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)	UniProt NCBI
ITSN2	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)	UniProt NCBI
AP2M1	AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)	UniProt NCBI
SV2A	Synaptic vesicle glycoprotein 2A	UniProt NCBI
BCR	Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)	UniProt NCBI
DIEXF	Digestive organ expansion factor homolog	UniProt NCBI
GULP1	PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)	UniProt NCBI
PJA2	E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)	UniProt NCBI
KIF13A	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)	UniProt NCBI
SNX29	Sorting nexin-29 (RUN domain-containing protein 2A)	UniProt NCBI
NUMB	Protein numb homolog (h-Numb) (Protein S171)	UniProt NCBI
MEA1	Male-enhanced antigen 1 (MEA-1)	UniProt NCBI
AP1S3	AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-164938	0.0385771221176	0.133333333333	AP1S3 AP2M1	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Edges

Protein 1	Protein 2	Score	Precision	Evidence
AP2M1	ITSN2	0.991	0.909	bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
AP2M1	CALCOCO1	0.978	0.894	bioplex (AP2M1) bioplex_WMM youn_WMM
AP2M1	KIF13A	0.962	0.869	bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
MEA1	AP2M1	0.491	0.619	bioplex (AP2M1) bioplex_WMM
AP2M1	REXO1	0.45	0.594	bioplex (AP2M1) bioplex_WMM
AP2M1	DIEXF	0.427	0.576	bioplex (AP2M1) bioplex_WMM youn_WMM
AP2M1	PJA2	0.283	0.488	bioplex (AP2M1) bioplex_WMM youn_WMM
AP1S3	AP2M1	0.282	0.487	bioplex (AP2M1) bioplex_WMM
GULP1	AP2M1	0.186	0.441	bioplex (AP2M1) bioplex_WMM youn_WMM
AP2M1	NUMB	0.145	0.408	hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
AP2M1	BCR	0.116	0.387	bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM
AP2M1	SV2A	0.089	0.354	bioplex (AP2M1) bioplex_WMM youn_WMM
AP2M1	PER1	0.057	0.324	hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM
AP2M1	SNX29	0.049	0.295	bioplex (AP2M1) bioplex_WMM youn_WMM
MEA1	AP1S3	0.01	0.111	bioplex_WMM WMM_only
NUMB	ITSN2	0.009	0.105	bioplex_WMM youn_WMM gupta_WMM WMM_only
REXO1	KIF13A	0.009	0.102	bioplex_WMM WMM_only
SNX29	REXO1	0.009	0.102	bioplex_WMM WMM_only
REXO1	ITSN2	0.009	0.102	bioplex_WMM WMM_only
AP1S3	REXO1	0.009	0.102	bioplex_WMM WMM_only
SNX29	ITSN2	0.009	0.097	bioplex_WMM youn_WMM WMM_only
NUMB	BCR	0.009	0.091	bioplex_WMM boldt youn_WMM boldt_WMM
NUMB	REXO1	0.009	0.091	bioplex_WMM WMM_only
KIF13A	ITSN2	0.009	0.096	bioplex_WMM youn_WMM WMM_only
GULP1	REXO1	0.009	0.095	bioplex_WMM WMM_only
SNX29	KIF13A	0.009	0.095	bioplex_WMM WMM_only
REXO1	DIEXF	0.009	0.097	bioplex_WMM WMM_only
MEA1	REXO1	0.008	0.094	bioplex_WMM WMM_only
AP1S3	ITSN2	0.008	0.091	bioplex_WMM WMM_only
AP1S3	KIF13A	0.008	0.091	bioplex_WMM WMM_only
AP1S3	SNX29	0.008	0.091	bioplex_WMM WMM_only
SNX29	NUMB	0.008	0.09	bioplex_WMM youn_WMM WMM_only
NUMB	KIF13A	0.008	0.087	bioplex_WMM youn_WMM WMM_only
GULP1	ITSN2	0.008	0.089	bioplex_WMM youn_WMM WMM_only
GULP1	KIF13A	0.008	0.083	bioplex_WMM WMM_only
GULP1	SNX29	0.008	0.083	bioplex_WMM WMM_only
CALCOCO1	REXO1	0.008	0.082	bioplex_WMM WMM_only
REXO1	BCR	0.008	0.083	bioplex_WMM WMM_only
KIF13A	DIEXF	0.008	0.082	bioplex_WMM WMM_only
SNX29	DIEXF	0.008	0.082	bioplex_WMM WMM_only
AP1S3	NUMB	0.008	0.082	bioplex_WMM WMM_only
DIEXF	ITSN2	0.008	0.082	bioplex_WMM WMM_only
MEA1	SNX29	0.008	0.072	bioplex_WMM WMM_only
MEA1	KIF13A	0.008	0.072	bioplex_WMM WMM_only
MEA1	ITSN2	0.008	0.072	bioplex_WMM WMM_only
PER1	REXO1	0.008	0.071	bioplex_WMM WMM_only
GULP1	AP1S3	0.008	0.068	bioplex_WMM WMM_only
BCR	KIF13A	0.008	0.068	bioplex_WMM youn_WMM gupta_WMM WMM_only
GULP1	NUMB	0.008	0.068	bioplex_WMM youn_WMM WMM_only
SNX29	BCR	0.008	0.07	bioplex_WMM youn_WMM WMM_only
AP1S3	DIEXF	0.008	0.06	bioplex_WMM WMM_only
CALCOCO1	ITSN2	0.008	0.06	bioplex_WMM youn_WMM WMM_only
BCR	ITSN2	0.008	0.059	bioplex_WMM youn_WMM gupta_WMM WMM_only
NUMB	DIEXF	0.008	0.051	bioplex_WMM youn_WMM WMM_only
SNX29	CALCOCO1	0.008	0.04	bioplex_WMM WMM_only
CALCOCO1	KIF13A	0.008	0.04	bioplex_WMM WMM_only
MEA1	NUMB	0.008	0.035	bioplex_WMM WMM_only
GULP1	DIEXF	0.008	0.035	bioplex_WMM WMM_only
MEA1	GULP1	0.008	0.024	bioplex_WMM WMM_only
PER1	ITSN2	0.008	0.02	bioplex_WMM WMM_only
PER1	KIF13A	0.008	0.02	bioplex_WMM WMM_only
SNX29	PER1	0.008	0.02	bioplex_WMM WMM_only
MEA1	BCR	0.008	0.023	bioplex_WMM WMM_only
AP1S3	CALCOCO1	0.008	0.023	bioplex_WMM WMM_only
REXO1	PJA2	0.008	0.027	bioplex_WMM WMM_only
NUMB	CALCOCO1	0.008	0.027	bioplex_WMM youn_WMM WMM_only
REXO1	SV2A	0.008	0.024	bioplex_WMM WMM_only
AP1S3	BCR	0.008	0.025	bioplex_WMM WMM_only
MEA1	DIEXF	0.008	0.027	bioplex_WMM WMM_only
GULP1	CALCOCO1	0.007	0.009	bioplex_WMM WMM_only
AP1S3	PER1	0.007	0.01	bioplex_WMM WMM_only
GULP1	BCR	0.007	0.01	bioplex_WMM WMM_only
ITSN2	PJA2	0.007	0.012	bioplex_WMM youn_WMM WMM_only
CALCOCO1	DIEXF	0.007	0.004	bioplex_WMM WMM_only
SNX29	PJA2	0.007	0.005	bioplex_WMM youn_WMM WMM_only
GULP1	PER1	0.007	0.006	bioplex_WMM WMM_only
MEA1	CALCOCO1	0.007	0.009	bioplex_WMM WMM_only
BCR	DIEXF	0.007	0.007	bioplex_WMM youn_WMM WMM_only
KIF13A	PJA2	0.007	0.005	bioplex_WMM WMM_only
SV2A	ITSN2	0.007	0.002	bioplex_WMM youn_WMM WMM_only
SNX29	SV2A	0.007	0.009	bioplex_WMM WMM_only
SV2A	KIF13A	0.007	0.009	bioplex_WMM WMM_only
NUMB	PJA2	0.007	0.009	bioplex_WMM youn_WMM WMM_only
PER1	DIEXF	0.007	0.003	bioplex_WMM WMM_only
NUMB	PER1	0.007	0.007	hein_WMM bioplex_WMM WMM_only
MEA1	PER1	0.007	0.004	bioplex_WMM WMM_only
AP1S3	PJA2	0.007	0.004	bioplex_WMM WMM_only
AP1S3	SV2A	0.007	0.0	bioplex_WMM WMM_only
CALCOCO1	BCR	0.007	0.006	bioplex_WMM WMM_only
NUMB	SV2A	0.007	0.004	bioplex_WMM youn_WMM WMM_only
GULP1	PJA2	0.007	0.001	bioplex_WMM youn_WMM WMM_only
MEA1	PJA2	0.007	0.0	bioplex_WMM WMM_only
CALCOCO1	PER1	0.007	0.002	bioplex_WMM WMM_only
PER1	BCR	0.007	0.002	bioplex_WMM WMM_only
GULP1	SV2A	0.007	0.004	bioplex_WMM WMM_only
DIEXF	PJA2	0.007	0.005	bioplex_WMM WMM_only
SV2A	DIEXF	0.007	0.004	bioplex_WMM WMM_only
MEA1	SV2A	0.007	0.003	bioplex_WMM WMM_only
CALCOCO1	PJA2	0.007	0.002	bioplex_WMM WMM_only
BCR	PJA2	0.007	0.006	bioplex_WMM youn_WMM WMM_only
CALCOCO1	SV2A	0.007	0.0	bioplex_WMM WMM_only
SV2A	BCR	0.007	0.007	bioplex_WMM youn_WMM WMM_only
PER1	SV2A	0.006	0.003	bioplex_WMM WMM_only
PER1	PJA2	0.006	0.006	bioplex_WMM youn_WMM WMM_only
SV2A	PJA2	0.006	0.005	bioplex_WMM youn_WMM WMM_only

Images

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Complex HuMAP2_03989 has an average edge precision of 0.111 which is ranked 6909 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CALCOCO1	HuMAP2_02263 HuMAP2_03989 HuMAP2_06613
REXO1	HuMAP2_03989 HuMAP2_06613
PER1	HuMAP2_02639 HuMAP2_02822 HuMAP2_03989 HuMAP2_05794 HuMAP2_06686
ITSN2	HuMAP2_03989 HuMAP2_04816 HuMAP2_06613
AP2M1	HuMAP2_01005 HuMAP2_01114 HuMAP2_03002 HuMAP2_03989 HuMAP2_06613 HuMAP2_06848
SV2A	HuMAP2_03989 HuMAP2_06613
BCR	HuMAP2_03989 HuMAP2_06407
DIEXF	HuMAP2_03989 HuMAP2_04742 HuMAP2_06613
GULP1	HuMAP2_00754 HuMAP2_01612 HuMAP2_03989 HuMAP2_03997 HuMAP2_04617 HuMAP2_06179
PJA2	HuMAP2_03989 HuMAP2_06613
KIF13A	HuMAP2_03989 HuMAP2_05118 HuMAP2_06613
SNX29	HuMAP2_01807 HuMAP2_03989 HuMAP2_05715 HuMAP2_06613
NUMB	HuMAP2_01891 HuMAP2_03989 HuMAP2_06613
MEA1	HuMAP2_00403 HuMAP2_01376 HuMAP2_02646 HuMAP2_03989 HuMAP2_04106 HuMAP2_04864 HuMAP2_05731 HuMAP2_05979
AP1S3	HuMAP2_00989 HuMAP2_02368 HuMAP2_03338 HuMAP2_03989 HuMAP2_06613

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03989