hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03991

Confidence: Medium High

Genename	Protein Name	Links
CISD1	CDGSH iron-sulfur domain-containing protein 1 (MitoNEET)	UniProt NCBI
CISD2	CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)	UniProt NCBI
PHB2	Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)	UniProt NCBI
SLC25A6	ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]	UniProt NCBI
SLC25A1	Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)	UniProt NCBI
SLC25A4	ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4)	UniProt NCBI
SLC25A5	ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]	UniProt NCBI
RIC3	Protein RIC-3 (Resistant to inhibitor of cholinesterase 3)	UniProt NCBI
PHB	Prohibitin	UniProt NCBI
VDAC2	Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)	UniProt NCBI
VDAC3	Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)	UniProt NCBI
SCD	Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) (hSCD1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6289	7.48797299237e-11	0.333333333333	VDAC2 PHB SLC25A5 PHB2	prohibitin 2 complex, mitochondrial
REAC:R-HSA-180897	9.65221580922e-08	0.25	SLC25A6 SLC25A4 SLC25A5	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
GO:0031966	4.15525439886e-07	0.75	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 VDAC2 VDAC3 SLC25A1	mitochondrial membrane
REAC:R-HSA-8949215	5.1237221161e-07	0.333333333333	VDAC2 VDAC3 PHB PHB2	Mitochondrial calcium ion transport
GO:0005740	7.46823727349e-07	0.75	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 VDAC2 VDAC3 SLC25A1	mitochondrial envelope
KEGG:05012	1.37358258823e-06	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	Parkinson disease
KEGG:04022	2.4170254098e-06	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	cGMP-PKG signaling pathway
KEGG:04218	2.78104814087e-06	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	Cellular senescence
KEGG:04217	3.52204638828e-06	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	Necroptosis
KEGG:04020	4.41210500439e-06	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	Calcium signaling pathway
KEGG:05016	7.3281647134e-06	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	Huntington disease
KEGG:05166	1.28479142516e-05	0.416666666667	SLC25A6 SLC25A4 VDAC3 SLC25A5 VDAC2	Human T-cell leukemia virus 1 infection
REAC:R-HSA-83936	1.58684890602e-05	0.25	SLC25A6 SLC25A4 SLC25A5	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
GO:0005739	2.54485810079e-05	0.833333333333	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 CISD1 VDAC2 VDAC3 SLC25A1	mitochondrion
REAC:R-HSA-382551	2.72904346749e-05	0.583333333333	PHB2 SLC25A5 PHB SLC25A6 SLC25A4 VDAC2 VDAC3	Transport of small molecules
GO:0044429	3.09666218098e-05	0.75	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 VDAC2 VDAC3 SLC25A1	mitochondrial part
GO:0031967	4.30981393866e-05	0.75	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 VDAC2 VDAC3 SLC25A1	organelle envelope
GO:0031975	4.30981393866e-05	0.75	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 VDAC2 VDAC3 SLC25A1	envelope
GO:0005471	7.98841194917e-05	0.25	SLC25A6 SLC25A4 SLC25A5	ATP:ADP antiporter activity
GO:0015217	0.00039905855691	0.25	SLC25A6 SLC25A4 SLC25A5	ADP transmembrane transporter activity
REAC:R-HSA-176033	0.00051950788856	0.25	SLC25A6 SLC25A4 SLC25A5	Interactions of Vpr with host cellular proteins
REAC:R-HSA-425397	0.000678929758518	0.25	SLC25A6 SLC25A4 SLC25A5	Transport of vitamins, nucleosides, and related molecules
GO:0008509	0.000700813179591	0.5	SLC25A1 SLC25A4 SLC25A5 SLC25A6 VDAC2 VDAC3	anion transmembrane transporter activity
GO:0005347	0.00239001245467	0.25	SLC25A6 SLC25A4 SLC25A5	ATP transmembrane transporter activity
WP:WP111	0.00334988097487	0.25	SLC25A6 SLC25A4 SLC25A5	Electron Transport Chain (OXPHOS system in mitochondria)
GO:0000295	0.00723656577432	0.25	SLC25A6 SLC25A4 SLC25A5	adenine nucleotide transmembrane transporter activity
GO:0005346	0.00723656577432	0.25	SLC25A6 SLC25A4 SLC25A5	purine ribonucleotide transmembrane transporter activity
GO:0005743	0.00768929354915	0.5	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 SLC25A1	mitochondrial inner membrane
KEGG:05164	0.00900297300618	0.25	SLC25A6 SLC25A4 SLC25A5	Influenza A
GO:0015216	0.00904160579552	0.25	SLC25A6 SLC25A4 SLC25A5	purine nucleotide transmembrane transporter activity
GO:0019866	0.0121687187542	0.5	PHB2 SLC25A4 PHB SLC25A5 SLC25A6 SLC25A1	organelle inner membrane
GO:0140323	0.0135004782501	0.25	SLC25A6 SLC25A4 SLC25A5	solute:anion antiporter activity
GO:0015301	0.0135004782501	0.25	SLC25A6 SLC25A4 SLC25A5	anion:anion antiporter activity
REAC:R-HSA-8949664	0.0171411088968	0.166666666667	PHB PHB2	Processing of SMDT1
GO:0031090	0.0185226245312	0.833333333333	SCD PHB2 SLC25A4 PHB SLC25A5 SLC25A6 CISD2 VDAC2 VDAC3 SLC25A1	organelle membrane
KEGG:04216	0.0187116925088	0.166666666667	VDAC2 VDAC3	Ferroptosis
GO:0015215	0.0192207384294	0.25	SLC25A6 SLC25A4 SLC25A5	nucleotide transmembrane transporter activity
GO:0015605	0.0226023794314	0.25	SLC25A6 SLC25A4 SLC25A5	organophosphate ester transmembrane transporter activity
KEGG:04979	0.0239813373697	0.166666666667	VDAC2 VDAC3	Cholesterol metabolism
REAC:R-HSA-162909	0.0269983989954	0.25	SLC25A6 SLC25A4 SLC25A5	Host Interactions of HIV factors
WP:WP4313	0.0277023711436	0.166666666667	VDAC2 VDAC3	Ferroptosis
GO:0015207	0.029754345151	0.166666666667	SLC25A4 SLC25A5	adenine transmembrane transporter activity

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PHB2	PHB	1.0	0.949	hein_WMM bioplex (PHB2) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM
SLC25A5	VDAC2	0.988	0.901	bioplex (SLC25A5,VDAC2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM
PHB	VDAC2	0.988	0.901	hein_WMM bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM
SLC25A5	PHB	0.988	0.902	hein_WMM bioplex (PHB,SLC25A5) bioplex_WMM boldt fraction boldt_WMM treiber_WMM
SLC25A5	PHB2	0.987	0.902	hein_WMM bioplex (PHB2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM
PHB2	SLC25A4	0.807	0.767	bioplex_WMM boldt gupta_WMM fraction boldt_WMM
VDAC3	PHB	0.733	0.738	hein_WMM bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM
VDAC2	SLC25A4	0.71	0.729	bioplex (SLC25A4) bioplex_WMM boldt youn_WMM fraction boldt_WMM
RIC3	PHB	0.693	0.717	bioplex (RIC3) bioplex_WMM
VDAC3	SLC25A4	0.616	0.675	bioplex (VDAC3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM
PHB2	SLC25A6	0.601	0.671	bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM
RIC3	PHB2	0.589	0.663	bioplex (RIC3) bioplex_WMM
SLC25A5	VDAC3	0.549	0.643	bioplex (VDAC3) bioplex_WMM boldt fraction boldt_WMM treiber_WMM
VDAC3	SLC25A6	0.532	0.637	bioplex (SLC25A6,VDAC3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM
SLC25A6	VDAC2	0.523	0.633	bioplex (SLC25A6,VDAC2) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM
PHB	SLC25A4	0.43	0.578	bioplex (PHB) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
CISD1	SLC25A4	0.291	0.492	bioplex_WMM boldt fraction boldt_WMM
CISD1	SLC25A6	0.251	0.474	bioplex_WMM boldt gupta_WMM fraction boldt_WMM
CISD1	VDAC3	0.244	0.468	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
SLC25A5	SLC25A6	0.186	0.44	bioplex (SLC25A5,SLC25A6) bioplex_WMM boldt boldt_WMM treiber_WMM
VDAC3	PHB2	0.176	0.435	hein_WMM bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM
SLC25A5	SLC25A4	0.157	0.416	bioplex_WMM boldt fraction boldt_WMM
PHB	SLC25A6	0.143	0.405	bioplex (PHB) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
PHB2	VDAC2	0.114	0.383	hein_WMM bioplex (PHB2,VDAC2) bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM
SLC25A5	CISD1	0.112	0.381	bioplex_WMM boldt fraction boldt_WMM
CISD1	VDAC2	0.109	0.376	bioplex_WMM Guru boldt fraction boldt_WMM
SLC25A5	SLC25A1	0.089	0.356	hein_WMM bioplex_WMM boldt fraction boldt_WMM treiber_WMM
CISD2	VDAC2	0.05	0.298	bioplex_WMM Guru youn_WMM fraction treiber_WMM
SLC25A5	SCD	0.044	0.277	bioplex_WMM Guru boldt fraction boldt_WMM
VDAC3	CISD2	0.043	0.27	bioplex_WMM Guru gupta_WMM fraction
SLC25A6	SLC25A4	0.039	0.266	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
SLC25A1	SCD	0.023	0.211	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
VDAC3	VDAC2	0.022	0.209	hein_WMM bioplex (VDAC3) bioplex_WMM boldt boldt_WMM treiber_WMM
CISD2	SLC25A4	0.017	0.174	bioplex_WMM youn_WMM gupta_WMM fraction
SLC25A5	CISD2	0.014	0.137	bioplex_WMM fraction treiber_WMM
CISD2	SLC25A6	0.014	0.142	bioplex_WMM youn_WMM gupta_WMM fraction
CISD1	SCD	0.009	0.096	bioplex_WMM boldt gupta_WMM boldt_WMM
CISD2	PHB2	0.008	0.091	bioplex_WMM Guru gupta_WMM fraction treiber_WMM
CISD1	PHB2	0.008	0.084	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
VDAC2	SCD	0.008	0.033	bioplex_WMM boldt youn_WMM fraction boldt_WMM
SLC25A1	VDAC2	0.008	0.012	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
PHB2	SLC25A1	0.007	0.005	bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM
PHB2	SCD	0.007	0.003	bioplex_WMM boldt gupta_WMM boldt_WMM
CISD1	CISD2	0.007	0.001	bioplex_WMM gupta_WMM WMM_only
CISD2	SLC25A1	0.007	0.001	bioplex_WMM youn_WMM gupta_WMM WMM_only
SLC25A1	SLC25A4	0.007	0.006	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
CISD2	SCD	0.007	0.002	bioplex_WMM youn_WMM gupta_WMM WMM_only
SLC25A6	SCD	0.006	0.004	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
PHB	SLC25A1	0.006	0.004	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
PHB	SCD	0.006	0.004	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
SLC25A5	RIC3	0.006	0.009	bioplex (RIC3)
RIC3	SLC25A6	0.006	0.007	bioplex (RIC3)
SCD	SLC25A4	0.006	0.011	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
VDAC3	SLC25A1	0.006	0.01	bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM
SLC25A6	SLC25A1	0.005	0.007	bioplex (SLC25A6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
VDAC3	SCD	0.005	0.009	bioplex_WMM boldt gupta_WMM fraction boldt_WMM
CISD2	PHB	0.005	0.009	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
CISD1	SLC25A1	0.004	0.006	bioplex_WMM boldt gupta_WMM boldt_WMM
CISD1	PHB	0.003	0.007	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
RIC3	VDAC3	0.0	0.009	bioplex (RIC3) bioplex_WMM

Images

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Complex HuMAP2_03991 has an average edge precision of 0.317 which is ranked 4379 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CISD1	HuMAP2_00435 HuMAP2_03081 HuMAP2_03276 HuMAP2_03991 HuMAP2_04228 HuMAP2_05480 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
CISD2	HuMAP2_00435 HuMAP2_00533 HuMAP2_02453 HuMAP2_02928 HuMAP2_03081 HuMAP2_03991 HuMAP2_05351 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
PHB2	HuMAP2_01061 HuMAP2_02355 HuMAP2_03081 HuMAP2_03991 HuMAP2_04908 HuMAP2_05414 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798
SLC25A6	HuMAP2_03081 HuMAP2_03131 HuMAP2_03991 HuMAP2_04908 HuMAP2_05414 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798
SLC25A1	HuMAP2_03081 HuMAP2_03426 HuMAP2_03991
SLC25A4	HuMAP2_03081 HuMAP2_03276 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05807 HuMAP2_06116 HuMAP2_06329 HuMAP2_06798
SLC25A5	HuMAP2_00215 HuMAP2_01502 HuMAP2_03081 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05807 HuMAP2_05840
RIC3	HuMAP2_00297 HuMAP2_01061 HuMAP2_03081 HuMAP2_03991 HuMAP2_04721 HuMAP2_04947 HuMAP2_06329 HuMAP2_06798
PHB	HuMAP2_01061 HuMAP2_01502 HuMAP2_02355 HuMAP2_03081 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798
VDAC2	HuMAP2_03081 HuMAP2_03970 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05588 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
VDAC3	HuMAP2_00435 HuMAP2_02584 HuMAP2_03081 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
SCD	HuMAP2_03081 HuMAP2_03426 HuMAP2_03970 HuMAP2_03991

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03991