hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04002
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TSEN15 | tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15) | UniProt NCBI |
| GREB1L | GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein) | UniProt NCBI |
| TSEN34 | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | UniProt NCBI |
| CLP1 | Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1) | UniProt NCBI |
| TSEN2 | tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) | UniProt NCBI |
| TSEN54 | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5283 | 6.09820937128e-17 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | tRNA splicing endonuclease |
| GO:0006388 | 9.83518706814e-11 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | tRNA splicing, via endonucleolytic cleavage and ligation |
| GO:0000394 | 1.47519544769e-10 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | RNA splicing, via endonucleolytic cleavage and ligation |
| REAC:R-HSA-6784531 | 5.08249248018e-10 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | tRNA processing in the nucleus |
| CORUM:5284 | 2.25356268047e-09 | 0.5 | TSEN54 CLP1 TSEN2 | RNA endonuclease (SEN2deltaEx8, SEN54, CLP1) |
| REAC:R-HSA-72306 | 1.33498033125e-08 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | tRNA processing |
| GO:0000213 | 1.81637152046e-06 | 0.5 | TSEN34 TSEN2 TSEN54 | tRNA-intron endonuclease activity |
| GO:0000214 | 1.81637152046e-06 | 0.5 | TSEN54 CLP1 TSEN2 | tRNA-intron endonuclease complex |
| GO:0000379 | 1.81637152046e-06 | 0.5 | TSEN34 TSEN2 TSEN54 | tRNA-type intron splice site recognition and cleavage |
| HP:0000253 | 2.25404354073e-06 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Progressive microcephaly |
| GO:0008033 | 3.872315266e-06 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | tRNA processing |
| HP:0003577 | 4.83740071849e-06 | 0.833333333333 | GREB1L TSEN15 TSEN54 CLP1 TSEN2 | Congenital onset |
| GO:0016892 | 1.81582264982e-05 | 0.5 | TSEN34 TSEN2 TSEN54 | endoribonuclease activity, producing 3'-phosphomonoesters |
| GO:0006399 | 2.9828141854e-05 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | tRNA metabolic process |
| HP:0005484 | 3.7653275253e-05 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Postnatal microcephaly |
| REAC:R-HSA-8953854 | 0.000150175559311 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Metabolism of RNA |
| GO:0004549 | 0.000824951429902 | 0.5 | TSEN34 TSEN2 TSEN54 | tRNA-specific ribonuclease activity |
| GO:0016894 | 0.00101517134288 | 0.5 | TSEN34 TSEN2 TSEN54 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters |
| HP:0007308 | 0.00112625143517 | 0.333333333333 | TSEN2 TSEN54 | Extrapyramidal dyskinesia |
| GO:0034470 | 0.00120907776661 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | ncRNA processing |
| HP:0009121 | 0.00226728269849 | 1.0 | TSEN15 TSEN54 TSEN2 CLP1 GREB1L TSEN34 | Abnormal axial skeleton morphology |
| HP:0003674 | 0.0023356695228 | 0.833333333333 | GREB1L TSEN15 TSEN54 CLP1 TSEN2 | Onset |
| HP:0000252 | 0.0025384284618 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Microcephaly |
| HP:0040195 | 0.00259479391269 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Decreased head circumference |
| GO:0008380 | 0.00270779091032 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | RNA splicing |
| GO:0034660 | 0.00405016747169 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | ncRNA metabolic process |
| HP:0000478 | 0.00544554588664 | 1.0 | TSEN15 TSEN54 TSEN2 CLP1 GREB1L TSEN34 | Abnormality of the eye |
| HP:0011842 | 0.00575247673042 | 1.0 | TSEN15 TSEN54 TSEN2 CLP1 GREB1L TSEN34 | Abnormality of skeletal morphology |
| GO:1902555 | 0.00592798461195 | 0.5 | TSEN54 CLP1 TSEN2 | endoribonuclease complex |
| HP:0007364 | 0.00616985985338 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Aplasia/Hypoplasia of the cerebrum |
| HP:0000924 | 0.00703502836914 | 1.0 | TSEN15 TSEN54 TSEN2 CLP1 GREB1L TSEN34 | Abnormality of the skeletal system |
| HP:0000234 | 0.00714716296863 | 1.0 | TSEN15 TSEN54 TSEN2 CLP1 GREB1L TSEN34 | Abnormality of the head |
| HP:0000152 | 0.00743403304806 | 1.0 | TSEN15 TSEN54 TSEN2 CLP1 GREB1L TSEN34 | Abnormality of head or neck |
| HP:0000240 | 0.00761896072068 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Abnormality of skull size |
| HP:0002059 | 0.00871466952872 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Cerebral atrophy |
| HP:0007369 | 0.00907655301362 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Atrophy/Degeneration affecting the cerebrum |
| GO:1905348 | 0.00986527098502 | 0.5 | TSEN54 CLP1 TSEN2 | endonuclease complex |
| HP:0002363 | 0.0102416371513 | 0.5 | TSEN54 CLP1 TSEN2 | Abnormality of brainstem morphology |
| HP:0031797 | 0.0125172292132 | 0.833333333333 | GREB1L TSEN15 TSEN54 CLP1 TSEN2 | Clinical course |
| HP:0012444 | 0.0130485354289 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Brain atrophy |
| HP:0002977 | 0.0138079720554 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Aplasia/Hypoplasia involving the central nervous system |
| HP:0001321 | 0.0187800119955 | 0.5 | TSEN34 TSEN2 TSEN54 | Cerebellar hypoplasia |
| HP:0002060 | 0.0221695518784 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Abnormality of the cerebrum |
| HP:0007367 | 0.0223072471294 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Atrophy/Degeneration affecting the central nervous system |
| HP:0100547 | 0.0235294088503 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Abnormality of forebrain morphology |
| HP:0001257 | 0.0259452832381 | 0.666666666667 | TSEN15 TSEN54 CLP1 TSEN2 | Spasticity |
| HP:0002179 | 0.030358517586 | 0.333333333333 | TSEN2 TSEN54 | Opisthotonus |
| HP:0100022 | 0.0360288496277 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Abnormality of movement |
| HP:0002120 | 0.0421345110279 | 0.5 | TSEN15 CLP1 TSEN54 | Cerebral cortical atrophy |
| GO:0004521 | 0.0447070305646 | 0.5 | TSEN34 TSEN2 TSEN54 | endoribonuclease activity |
| HP:0000929 | 0.0467452239687 | 0.833333333333 | TSEN15 TSEN34 TSEN54 CLP1 TSEN2 | Abnormal skull morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TSEN2 | TSEN54 | 0.465 | 0.602 | bioplex (TSEN2) bioplex_WMM |
| CLP1 | TSEN2 | 0.319 | 0.511 | bioplex (TSEN2) bioplex_WMM |
| TSEN2 | TSEN34 | 0.232 | 0.47 | bioplex (TSEN2) bioplex_WMM |
| TSEN2 | GREB1L | 0.101 | 0.363 | bioplex (TSEN2) bioplex_WMM |
| TSEN2 | TSEN15 | 0.051 | 0.298 | bioplex (TSEN15,TSEN2) bioplex_WMM |
| TSEN15 | TSEN34 | 0.03 | 0.232 | bioplex (TSEN15) bioplex_WMM fraction |
| TSEN15 | TSEN54 | 0.02 | 0.186 | bioplex (TSEN15) bioplex_WMM |
| CLP1 | TSEN15 | 0.014 | 0.143 | bioplex (TSEN15) bioplex_WMM |
| TSEN34 | TSEN54 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| CLP1 | TSEN54 | 0.01 | 0.133 | bioplex_WMM WMM_only |
| CLP1 | TSEN34 | 0.009 | 0.109 | bioplex_WMM youn_WMM WMM_only |
| TSEN15 | GREB1L | 0.008 | 0.096 | bioplex_WMM WMM_only |
| TSEN34 | GREB1L | 0.008 | 0.035 | bioplex_WMM WMM_only |
| GREB1L | TSEN54 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| CLP1 | GREB1L | 0.008 | 0.012 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04002 has an average edge precision of 0.224 which is ranked 5797 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TSEN15 | HuMAP2_03342 HuMAP2_04002 |
| GREB1L | HuMAP2_03342 HuMAP2_04002 |
| TSEN34 | HuMAP2_03342 HuMAP2_04002 |
| CLP1 | HuMAP2_00568 HuMAP2_04002 HuMAP2_05400 |
| TSEN2 | HuMAP2_03342 HuMAP2_04002 |
| TSEN54 | HuMAP2_03342 HuMAP2_04002 |