hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04011
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | UniProt NCBI |
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | UniProt NCBI |
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 2.29418690238e-18 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | RUNX3 regulates YAP1-mediated transcription |
| REAC:R-HSA-2032785 | 9.83412988132e-16 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| KEGG:04392 | 2.04153915614e-14 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | Hippo signaling pathway - multiple species |
| GO:0035329 | 1.27615466215e-13 | 0.875 | WWTR1 TEAD1 TEAD3 AMOTL2 TEAD4 YAP1 TEAD2 | hippo signaling |
| WP:WP3967 | 2.02440505484e-12 | 0.625 | YAP1 TEAD4 TEAD2 TEAD3 TEAD1 | miR-509-3p alteration of YAP1/ECM axis |
| WP:WP4542 | 6.58909843227e-11 | 0.625 | YAP1 TEAD4 TEAD2 TEAD3 TEAD1 | Overview of leukocyte-intrinsic Hippo pathway functions |
| REAC:R-HSA-8878159 | 2.31419920275e-10 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | Transcriptional regulation by RUNX3 |
| KEGG:04390 | 8.95131055255e-10 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | Hippo signaling pathway |
| WP:WP4533 | 5.27310139965e-09 | 0.5 | TEAD1 TEAD4 TEAD2 TEAD3 | Transcription co-factors SKI and SKIL protein partners |
| WP:WP4537 | 8.34548656562e-09 | 0.5 | TEAD1 TEAD4 TEAD2 TEAD3 | Hippo-Yap signaling pathway |
| WP:WP4541 | 3.80475561763e-08 | 0.625 | TEAD1 VGLL4 TEAD4 TEAD2 TEAD3 | Hippo-Merlin Signaling Dysregulation |
| WP:WP4534 | 1.73650512384e-07 | 0.5 | TEAD1 TEAD4 TEAD2 TEAD3 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| GO:0006367 | 2.78106571135e-06 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | transcription initiation from RNA polymerase II promoter |
| WP:WP4540 | 3.7791494928e-06 | 0.5 | TEAD1 TEAD4 TEAD2 TEAD3 | Pathways Regulating Hippo Signaling |
| GO:0006352 | 9.72116557692e-06 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | DNA-templated transcription, initiation |
| CORUM:6651 | 1.16880143691e-05 | 0.25 | YAP1 WWTR1 | WWTR1-YAP1 complex |
| REAC:R-HSA-2028269 | 1.74055112733e-05 | 0.375 | YAP1 WWTR1 AMOTL2 | Signaling by Hippo |
| GO:0001085 | 0.000457563898772 | 0.5 | TEAD1 TEAD4 TEAD2 TEAD3 | RNA polymerase II transcription factor binding |
| REAC:R-HSA-212436 | 0.000485403591864 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.000921019711578 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | RNA Polymerase II Transcription |
| WP:WP2857 | 0.00174278549879 | 0.375 | YAP1 TEAD2 TEAD1 | Mesodermal Commitment Pathway |
| REAC:R-HSA-74160 | 0.00174657105004 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | Gene expression (Transcription) |
| GO:0001223 | 0.0023070725905 | 0.375 | TEAD1 TEAD2 VGLL4 | transcription coactivator binding |
| GO:0008134 | 0.0024030857736 | 0.75 | TEAD4 TEAD3 TEAD2 TEAD1 YAP1 VGLL4 | transcription factor binding |
| GO:0005667 | 0.00365192644755 | 0.625 | YAP1 TEAD4 TEAD2 TEAD3 TEAD1 | transcription factor complex |
| REAC:R-HSA-8940973 | 0.00761952471968 | 0.25 | YAP1 WWTR1 | RUNX2 regulates osteoblast differentiation |
| REAC:R-HSA-8941326 | 0.0122816673814 | 0.25 | YAP1 WWTR1 | RUNX2 regulates bone development |
| GO:0071148 | 0.0126230555186 | 0.25 | YAP1 TEAD1 | TEAD-1-YAP complex |
| GO:0071149 | 0.0126230555186 | 0.25 | YAP1 TEAD2 | TEAD-2-YAP complex |
| GO:0001221 | 0.0131467756501 | 0.375 | TEAD1 TEAD2 VGLL4 | transcription cofactor binding |
| CORUM:6652 | 0.0248670854284 | 0.125 | WWTR1 | WWTR1 homodimer |
| GO:0045944 | 0.0262849659974 | 0.75 | WWTR1 TEAD4 TEAD3 TEAD1 YAP1 TEAD2 | positive regulation of transcription by RNA polymerase II |
| CORUM:7062 | 0.0497224828424 | 0.125 | WWTR1 | NFAT5-WWTR1 complex |
| CORUM:6647 | 0.0497224828424 | 0.125 | WWTR1 | MED15-WWTR1 complex |
| CORUM:6661 | 0.0497224828424 | 0.125 | WWTR1 | NEK8-WWTR1 complex |
| CORUM:6676 | 0.0497224828424 | 0.125 | WWTR1 | WWTR1-YWHAQ complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TEAD2 | TEAD4 | 1.0 | 0.949 | bioplex (TEAD2,TEAD4) bioplex_WMM |
| TEAD4 | YAP1 | 1.0 | 0.949 | hein_WMM bioplex (TEAD4) bioplex_WMM hein (YAP1) |
| VGLL4 | TEAD3 | 1.0 | 0.949 | bioplex (VGLL4) bioplex_WMM |
| TEAD4 | TEAD1 | 0.998 | 0.944 | hein_WMM bioplex (TEAD4) bioplex_WMM |
| TEAD3 | WWTR1 | 0.994 | 0.919 | bioplex (WWTR1) bioplex_WMM |
| TEAD4 | WWTR1 | 0.988 | 0.901 | bioplex (TEAD4,WWTR1) bioplex_WMM |
| TEAD2 | WWTR1 | 0.982 | 0.898 | bioplex (TEAD2) bioplex_WMM |
| TEAD2 | TEAD1 | 0.819 | 0.773 | bioplex (TEAD2) bioplex_WMM |
| VGLL4 | TEAD1 | 0.684 | 0.71 | bioplex (VGLL4) bioplex_WMM |
| TEAD4 | VGLL4 | 0.379 | 0.549 | bioplex (TEAD4,VGLL4) bioplex_WMM |
| TEAD1 | WWTR1 | 0.363 | 0.544 | bioplex (WWTR1) bioplex_WMM |
| TEAD2 | YAP1 | 0.169 | 0.426 | bioplex (TEAD2) bioplex_WMM |
| TEAD3 | YAP1 | 0.062 | 0.344 | hein_WMM hein (YAP1) |
| AMOTL2 | YAP1 | 0.055 | 0.304 | hein_WMM bioplex_WMM hein (YAP1) |
| TEAD1 | YAP1 | 0.044 | 0.279 | hein_WMM bioplex_WMM hein (YAP1) |
| TEAD4 | TEAD3 | 0.014 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| TEAD3 | TEAD1 | 0.013 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| YAP1 | WWTR1 | 0.01 | 0.134 | hein_WMM bioplex_WMM WMM_only |
| TEAD2 | VGLL4 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| VGLL4 | WWTR1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| VGLL4 | YAP1 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| AMOTL2 | WWTR1 | 0.008 | 0.034 | hein_WMM WMM_only |
| AMOTL2 | TEAD1 | 0.008 | 0.034 | hein_WMM WMM_only |
| AMOTL2 | TEAD3 | 0.008 | 0.034 | hein_WMM WMM_only |
| AMOTL2 | TEAD4 | 0.008 | 0.034 | hein_WMM WMM_only |
Images
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Complex HuMAP2_04011 has an average edge precision of 0.449 which is ranked 2884 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TEAD4 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD3 | HuMAP2_02068 HuMAP2_02569 HuMAP2_04011 HuMAP2_04016 HuMAP2_04805 |
| YAP1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 HuMAP2_04805 |
| AMOTL2 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04011 HuMAP2_04805 |
| TEAD2 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| WWTR1 | HuMAP2_04011 HuMAP2_04020 |
| VGLL4 | HuMAP2_01837 HuMAP2_02068 HuMAP2_02569 HuMAP2_04011 HuMAP2_04016 HuMAP2_04843 |