hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04012

Confidence: Medium High

Genename	Protein Name	Links
FGR	Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)	UniProt NCBI
CCDC186	Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2)	UniProt NCBI
YES1	Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)	UniProt NCBI
FYN	Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-2029481	1.61998317054e-07	0.75	FGR YES1 FYN	FCGR activation
CORUM:2564	3.01612206104e-05	0.5	FYN YES1	p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated
REAC:R-HSA-2029480	0.000110523666277	0.75	FGR YES1 FYN	Fcgamma receptor (FCGR) dependent phagocytosis
WP:WP4357	0.000387405527127	0.5	FYN YES1	NRF2-ARE regulation
REAC:R-HSA-1433559	0.000452175281072	0.5	FYN YES1	Regulation of KIT signaling
REAC:R-HSA-210990	0.000552609179875	0.5	FYN YES1	PECAM1 interactions
WP:WP2332	0.00124082421052	0.5	FYN YES1	Interleukin-11 Signaling Pathway
REAC:R-HSA-389513	0.00136571756437	0.5	FYN YES1	CTLA4 inhibitory signaling
WP:WP2203	0.00137286558226	0.5	FYN YES1	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
GO:0038083	0.00147288799354	0.75	FGR YES1 FYN	peptidyl-tyrosine autophosphorylation
REAC:R-HSA-912631	0.0019074750117	0.5	FYN YES1	Regulation of signaling by CBL
GO:0004715	0.00217043933003	0.75	FGR YES1 FYN	non-membrane spanning protein tyrosine kinase activity
REAC:R-HSA-3928663	0.00326103241616	0.5	FYN YES1	EPHA-mediated growth cone collapse
REAC:R-HSA-389356	0.00379215175563	0.5	FYN YES1	CD28 co-stimulation
KEGG:04520	0.00467243468204	0.5	FYN YES1	Adherens junction
REAC:R-HSA-1433557	0.00596538345738	0.5	FYN YES1	Signaling by SCF-KIT
REAC:R-HSA-512988	0.00667602194349	0.5	FYN YES1	Interleukin-3, Interleukin-5 and GM-CSF signaling
REAC:R-HSA-3928662	0.00742649434549	0.5	FYN YES1	EPHB-mediated forward signaling
REAC:R-HSA-1227986	0.00862684444961	0.5	FYN YES1	Signaling by ERBB2
REAC:R-HSA-3928665	0.0103665290697	0.5	FYN YES1	EPH-ephrin mediated repulsion of cells
REAC:R-HSA-388841	0.0143225711665	0.5	FYN YES1	Costimulation by the CD28 family
GO:0002433	0.0244411426287	0.75	FGR YES1 FYN	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0038096	0.0244411426287	0.75	FGR YES1 FYN	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038094	0.0244411426287	0.75	FGR YES1 FYN	Fc-gamma receptor signaling pathway
GO:0002431	0.0264744736345	0.75	FGR YES1 FYN	Fc receptor mediated stimulatory signaling pathway
GO:0031234	0.0264744736345	0.75	FGR YES1 FYN	extrinsic component of cytoplasmic side of plasma membrane
WP:WP306	0.0290430519819	0.5	FGR FYN	Focal Adhesion
REAC:R-HSA-109582	0.033540764945	0.75	FGR YES1 FYN	Hemostasis
REAC:R-HSA-2682334	0.0364771667023	0.5	FYN YES1	EPH-Ephrin signaling
CORUM:2351	0.0499140284799	0.25	FYN	ITGB6-FYN-FN1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
YES1	FGR	0.582	0.663	bioplex (YES1) bioplex_WMM
FYN	YES1	0.443	0.586	hein_WMM bioplex (FYN) bioplex_WMM
CCDC186	YES1	0.061	0.334	bioplex (YES1) bioplex_WMM
CCDC186	FGR	0.008	0.028	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04012 has an average edge precision of 0.403 which is ranked 3284 out of all 6965 complexes.

Related Complexes

Genename	Complexes
FGR	HuMAP2_03523 HuMAP2_03780 HuMAP2_04012 HuMAP2_06803
CCDC186	HuMAP2_00411 HuMAP2_00981 HuMAP2_01392 HuMAP2_03514 HuMAP2_04012
YES1	HuMAP2_01392 HuMAP2_03514 HuMAP2_03780 HuMAP2_04012 HuMAP2_06803
FYN	HuMAP2_00821 HuMAP2_02828 HuMAP2_04012 HuMAP2_06036

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04012