hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04020
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | UniProt NCBI |
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 5.15061336419e-16 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | RUNX3 regulates YAP1-mediated transcription |
| REAC:R-HSA-2032785 | 4.91025140719e-14 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| KEGG:04392 | 5.13204779729e-13 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | Hippo signaling pathway - multiple species |
| WP:WP3967 | 1.64338132547e-10 | 0.8 | TEAD2 TEAD4 YAP1 TEAD1 | miR-509-3p alteration of YAP1/ECM axis |
| REAC:R-HSA-8878159 | 1.20615415566e-09 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | Transcriptional regulation by RUNX3 |
| WP:WP4542 | 2.47269051758e-09 | 0.8 | TEAD2 TEAD4 YAP1 TEAD1 | Overview of leukocyte-intrinsic Hippo pathway functions |
| KEGG:04390 | 3.49578694931e-09 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | Hippo signaling pathway |
| GO:0035329 | 3.57083680546e-09 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | hippo signaling |
| WP:WP4533 | 5.48118700158e-07 | 0.6 | TEAD2 TEAD4 TEAD1 | Transcription co-factors SKI and SKIL protein partners |
| WP:WP4537 | 7.65599689843e-07 | 0.6 | TEAD2 TEAD4 TEAD1 | Hippo-Yap signaling pathway |
| CORUM:6651 | 6.70868171695e-06 | 0.4 | WWTR1 YAP1 | WWTR1-YAP1 complex |
| WP:WP4534 | 7.14388071161e-06 | 0.6 | TEAD2 TEAD4 TEAD1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| GO:0006367 | 9.13428048519e-06 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | transcription initiation from RNA polymerase II promoter |
| GO:0006352 | 2.5942147504e-05 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | DNA-templated transcription, initiation |
| WP:WP4540 | 7.07040269841e-05 | 0.6 | TEAD2 TEAD4 TEAD1 | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 0.00011435890921 | 0.6 | TEAD2 TEAD4 TEAD1 | Hippo-Merlin Signaling Dysregulation |
| WP:WP2857 | 0.000232147692986 | 0.6 | TEAD2 YAP1 TEAD1 | Mesodermal Commitment Pathway |
| REAC:R-HSA-212436 | 0.000239251603487 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.000412889072144 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | Gene expression (Transcription) |
| REAC:R-HSA-8940973 | 0.00230284247734 | 0.4 | WWTR1 YAP1 | RUNX2 regulates osteoblast differentiation |
| REAC:R-HSA-2028269 | 0.00230284247734 | 0.4 | WWTR1 YAP1 | Signaling by Hippo |
| REAC:R-HSA-8941326 | 0.00371437175588 | 0.4 | WWTR1 YAP1 | RUNX2 regulates bone development |
| GO:0071148 | 0.00450823411379 | 0.4 | TEAD1 YAP1 | TEAD-1-YAP complex |
| GO:0071149 | 0.00450823411379 | 0.4 | TEAD2 YAP1 | TEAD-2-YAP complex |
| GO:0045944 | 0.0197094416222 | 1.0 | TEAD2 TEAD4 WWTR1 YAP1 TEAD1 | positive regulation of transcription by RNA polymerase II |
| GO:0001085 | 0.0199719657189 | 0.6 | TEAD2 TEAD4 TEAD1 | RNA polymerase II transcription factor binding |
| GO:0005667 | 0.0200611173853 | 0.8 | TEAD2 TEAD4 YAP1 TEAD1 | transcription factor complex |
| CORUM:6652 | 0.0249780992026 | 0.2 | WWTR1 | WWTR1 homodimer |
| GO:0001134 | 0.0450641792523 | 0.4 | TEAD2 TEAD1 | transcription regulator recruiting activity |
| CORUM:6661 | 0.0499494897235 | 0.2 | WWTR1 | NEK8-WWTR1 complex |
| CORUM:6647 | 0.0499494897235 | 0.2 | WWTR1 | MED15-WWTR1 complex |
| CORUM:7062 | 0.0499494897235 | 0.2 | WWTR1 | NFAT5-WWTR1 complex |
| CORUM:6676 | 0.0499494897235 | 0.2 | WWTR1 | WWTR1-YWHAQ complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TEAD2 | TEAD4 | 1.0 | 0.949 | bioplex (TEAD2,TEAD4) bioplex_WMM |
| TEAD4 | YAP1 | 1.0 | 0.949 | hein_WMM bioplex (TEAD4) bioplex_WMM hein (YAP1) |
| TEAD4 | TEAD1 | 0.998 | 0.944 | hein_WMM bioplex (TEAD4) bioplex_WMM |
| TEAD4 | WWTR1 | 0.988 | 0.901 | bioplex (TEAD4,WWTR1) bioplex_WMM |
| TEAD2 | WWTR1 | 0.982 | 0.898 | bioplex (TEAD2) bioplex_WMM |
| TEAD2 | TEAD1 | 0.819 | 0.773 | bioplex (TEAD2) bioplex_WMM |
| TEAD1 | WWTR1 | 0.363 | 0.544 | bioplex (WWTR1) bioplex_WMM |
| TEAD2 | YAP1 | 0.169 | 0.426 | bioplex (TEAD2) bioplex_WMM |
| TEAD1 | YAP1 | 0.044 | 0.279 | hein_WMM bioplex_WMM hein (YAP1) |
| YAP1 | WWTR1 | 0.01 | 0.134 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04020 has an average edge precision of 0.68 which is ranked 1466 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TEAD4 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD2 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| WWTR1 | HuMAP2_04011 HuMAP2_04020 |
| YAP1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 HuMAP2_04805 |