hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04023

Confidence: Medium

Genename	Protein Name	Links
SYNM	Synemin (Desmuslin)	UniProt NCBI
NEFM	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	UniProt NCBI
NEFL	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	UniProt NCBI
NEFH	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	UniProt NCBI
INA	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	UniProt NCBI
NES	Nestin	UniProt NCBI
SYNC	Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)	UniProt NCBI
SPATA22	Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)	UniProt NCBI
DES	Desmin	UniProt NCBI
VIM	Vimentin	UniProt NCBI
XPNPEP3	Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005882	3.48862477582e-13	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	intermediate filament
GO:0045111	1.64691968071e-11	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	intermediate filament cytoskeleton
GO:0045103	2.4549713949e-09	0.545454545455	NES NEFL DES SYNM NEFH NEFM	intermediate filament-based process
GO:0045104	2.4549713949e-09	0.545454545455	NES NEFL DES SYNM NEFH NEFM	intermediate filament cytoskeleton organization
GO:0005200	3.75277774579e-09	0.636363636364	NEFL DES INA SYNM NEFH NEFM VIM	structural constituent of cytoskeleton
GO:0005883	1.20667211847e-07	0.363636363636	NEFM NEFH INA NEFL	neurofilament
GO:0099513	1.40079619029e-06	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	polymeric cytoskeletal fiber
GO:0033693	1.49850650438e-05	0.272727272727	NEFM NEFL NEFH	neurofilament bundle assembly
GO:0099512	1.59921657141e-05	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	supramolecular fiber
GO:0099081	1.7517714484e-05	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	supramolecular polymer
GO:0099080	1.77839322092e-05	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	supramolecular complex
GO:0045109	1.90667842707e-05	0.363636363636	NEFM DES NEFL NEFH	intermediate filament organization
WP:WP2447	0.000168663889087	0.272727272727	NEFM NEFL NEFH	Amyotrophic lateral sclerosis (ALS)
KEGG:05014	0.000275749154946	0.272727272727	NEFM NEFL NEFH	Amyotrophic lateral sclerosis (ALS)
GO:0005198	0.000510115903438	0.636363636364	NEFL DES INA SYNM NEFH NEFM VIM	structural molecule activity
GO:0045110	0.000523632447094	0.272727272727	NEFM NEFL NEFH	intermediate filament bundle assembly
WP:WP3680	0.000785986780671	0.272727272727	NEFM NEFL NEFH	Association Between Physico-Chemical Features and Toxicity Associated Pathways
WP:WP4352	0.000823817782697	0.363636363636	NEFM NEFL XPNPEP3 VIM	Ciliary landscape
GO:0019215	0.0024645761864	0.272727272727	NES SYNM VIM	intermediate filament binding
GO:0044430	0.0106952876619	0.727272727273	NES NEFL DES INA SYNM NEFH NEFM VIM	cytoskeletal part
WP:WP383	0.0220329934501	0.181818181818	DES VIM	Striated Muscle Contraction Pathway

Edges

Protein 1	Protein 2	Score	Precision	Evidence
DES	VIM	0.97	0.881	bioplex (VIM) bioplex_WMM boldt_WMM treiber_WMM
DES	NEFM	0.74	0.739	bioplex (NEFM) bioplex_WMM boldt_WMM
INA	NEFM	0.707	0.729	bioplex (NEFM) bioplex_WMM boldt_WMM
SYNC	DES	0.649	0.688	bioplex (SYNC) bioplex_WMM
NEFM	NEFL	0.447	0.591	bioplex (NEFL,NEFM) bioplex_WMM boldt boldt_WMM
VIM	NEFM	0.358	0.54	bioplex (NEFM,VIM) bioplex_WMM boldt (VIM) boldt_WMM
VIM	NES	0.216	0.464	hein_WMM bioplex (VIM) bioplex_WMM hein (NES) treiber_WMM
NEFM	NES	0.163	0.42	bioplex (NEFM) bioplex_WMM
VIM	INA	0.123	0.394	bioplex (VIM) bioplex_WMM boldt_WMM
VIM	NEFL	0.103	0.366	bioplex (NEFL,VIM) bioplex_WMM boldt (VIM) boldt_WMM
SYNC	VIM	0.057	0.324	hein_WMM bioplex (SYNC,VIM) bioplex_WMM hein (VIM)
SYNC	NEFM	0.045	0.28	bioplex (SYNC) bioplex_WMM
DES	SPATA22	0.042	0.27	bioplex (SPATA22) bioplex_WMM
NEFL	NEFH	0.033	0.247	bioplex (NEFH) bioplex_WMM
SYNC	SYNM	0.031	0.241	bioplex (SYNC) bioplex_WMM
XPNPEP3	VIM	0.028	0.233	hein_WMM bioplex (VIM) bioplex_WMM boldt (VIM) hein (VIM) boldt_WMM
SYNC	INA	0.025	0.215	bioplex (SYNC) bioplex_WMM
INA	NEFH	0.022	0.196	bioplex (NEFH) bioplex_WMM
INA	NEFL	0.014	0.14	bioplex_WMM youn_WMM WMM_only boldt_WMM
NEFM	NEFH	0.014	0.141	bioplex (NEFH) bioplex_WMM
SYNC	NEFL	0.014	0.144	bioplex (SYNC) bioplex_WMM
DES	INA	0.011	0.143	bioplex_WMM WMM_only boldt_WMM
DES	NES	0.011	0.142	bioplex_WMM WMM_only treiber_WMM
DES	NEFL	0.01	0.14	bioplex_WMM WMM_only boldt_WMM
XPNPEP3	SYNC	0.01	0.13	hein_WMM bioplex (SYNC) bioplex_WMM
NEFL	NES	0.01	0.126	bioplex_WMM WMM_only
INA	NES	0.01	0.099	bioplex_WMM WMM_only
XPNPEP3	NEFM	0.009	0.108	bioplex (NEFM) bioplex_WMM boldt boldt_WMM
XPNPEP3	DES	0.008	0.045	bioplex_WMM WMM_only boldt_WMM
NEFL	SYNM	0.008	0.031	bioplex_WMM youn_WMM WMM_only
DES	SYNM	0.008	0.026	bioplex_WMM WMM_only treiber_WMM
INA	SYNM	0.008	0.006	bioplex_WMM youn_WMM gupta_WMM WMM_only
VIM	SYNM	0.008	0.012	bioplex_WMM WMM_only boldt_WMM treiber_WMM
XPNPEP3	NEFL	0.007	0.01	bioplex (NEFL) bioplex_WMM boldt boldt_WMM
NEFM	SYNM	0.007	0.01	bioplex_WMM WMM_only
NES	SYNM	0.007	0.004	bioplex_WMM WMM_only treiber_WMM
XPNPEP3	SYNM	0.007	0.005	bioplex_WMM WMM_only
VIM	NEFH	0.007	0.006	bioplex (NEFH) bioplex_WMM
XPNPEP3	INA	0.007	0.003	bioplex_WMM WMM_only boldt_WMM
DES	NEFH	0.007	0.003	bioplex_WMM WMM_only
SPATA22	VIM	0.007	0.001	bioplex (SPATA22)
XPNPEP3	SPATA22	0.007	0.001	bioplex (SPATA22)
XPNPEP3	NES	0.006	0.004	bioplex_WMM WMM_only
XPNPEP3	NEFH	0.006	0.001	bioplex (NEFH) bioplex_WMM
SPATA22	NEFH	0.005	0.012	bioplex (SPATA22) bioplex_WMM
SYNC	NES	0.004	0.011	bioplex (SYNC) bioplex_WMM

Images

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Complex HuMAP2_04023 has an average edge precision of 0.203 which is ranked 6143 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SYNM	HuMAP2_01919 HuMAP2_04023 HuMAP2_05029 HuMAP2_05229 HuMAP2_05239
NEFM	HuMAP2_01819 HuMAP2_03169 HuMAP2_03286 HuMAP2_04023 HuMAP2_05486 HuMAP2_05674
NEFL	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_04987
NEFH	HuMAP2_01819 HuMAP2_04023 HuMAP2_04987
INA	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_05486
NES	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023
SYNC	HuMAP2_00514 HuMAP2_03169 HuMAP2_03286 HuMAP2_03392 HuMAP2_04023 HuMAP2_05229
SPATA22	HuMAP2_01489 HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_06460
DES	HuMAP2_01489 HuMAP2_01819 HuMAP2_03169 HuMAP2_03286 HuMAP2_03392 HuMAP2_04023 HuMAP2_05674 HuMAP2_06460
VIM	HuMAP2_01705 HuMAP2_01819 HuMAP2_03169 HuMAP2_03392 HuMAP2_04023 HuMAP2_04747 HuMAP2_05674
XPNPEP3	HuMAP2_00392 HuMAP2_01437 HuMAP2_01819 HuMAP2_03984 HuMAP2_04023 HuMAP2_05879

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04023