hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04025
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GFPT1 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) | UniProt NCBI |
| NR3C1 | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | UniProt NCBI |
| SIRT6 | NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) | UniProt NCBI |
| GFPT2 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446210 | 0.000281403908969 | 0.5 | GFPT1 GFPT2 | Synthesis of UDP-N-acetyl-glucosamine |
| KEGG:00250 | 0.00105499815766 | 0.5 | GFPT1 GFPT2 | Alanine, aspartate and glutamate metabolism |
| KEGG:00520 | 0.00206562690353 | 0.5 | GFPT1 GFPT2 | Amino sugar and nucleotide sugar metabolism |
| GO:0004360 | 0.00270494046827 | 0.5 | GFPT1 GFPT2 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
| GO:0070548 | 0.00270494046827 | 0.5 | GFPT1 GFPT2 | L-glutamine aminotransferase activity |
| KEGG:04931 | 0.0102286747914 | 0.5 | GFPT1 GFPT2 | Insulin resistance |
| REAC:R-HSA-446219 | 0.0165385846138 | 0.5 | GFPT1 GFPT2 | Synthesis of substrates in N-glycan biosythesis |
| HPA:030010_03 | 0.0244560243519 | 0.75 | GFPT2 NR3C1 SIRT6 | oral mucosa; squamous epithelial cells[Uncertain,High] |
| REAC:R-HSA-446193 | 0.0262582706021 | 0.5 | GFPT1 GFPT2 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| CORUM:4216 | 0.0499140284799 | 0.25 | NR3C1 | HNRNPU-NR3C1 complex |
| REAC:R-HSA-4085023 | 0.0499190562503 | 0.25 | GFPT1 | Defective GFPT1 causes CMSTA1 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GFPT1 | GFPT2 | 0.361 | 0.544 | bioplex (GFPT2) bioplex_WMM treiber_WMM |
| SIRT6 | GFPT2 | 0.296 | 0.496 | bioplex () bioplex_WMM |
| GFPT1 | SIRT6 | 0.075 | 0.357 | bioplex (SIRT6) bioplex_WMM |
| NR3C1 | SIRT6 | 0.063 | 0.348 | bioplex (SIRT6) bioplex_WMM |
| GFPT1 | NR3C1 | 0.007 | 0.004 | youn_WMM WMM_only |
Images
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Complex HuMAP2_04025 has an average edge precision of 0.35 which is ranked 3969 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GFPT1 | HuMAP2_00192 HuMAP2_03921 HuMAP2_04025 HuMAP2_04924 HuMAP2_06529 |
| NR3C1 | HuMAP2_00192 HuMAP2_00500 HuMAP2_04025 HuMAP2_04924 |
| SIRT6 | HuMAP2_00192 HuMAP2_03921 HuMAP2_04025 HuMAP2_04924 HuMAP2_06529 |
| GFPT2 | HuMAP2_00192 HuMAP2_03921 HuMAP2_04025 HuMAP2_04924 HuMAP2_06529 |