hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04026
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAP1GAP | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | UniProt NCBI |
| GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | UniProt NCBI |
| GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | UniProt NCBI |
| ANKRD13B | Ankyrin repeat domain-containing protein 13B | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha (G(i) alpha-3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-392170 | 3.09448976434e-06 | 0.6 | GNG7 GNG5 GNAI3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-202040 | 7.0533398358e-06 | 0.6 | GNG7 GNG5 GNAI3 | G-protein activation |
| REAC:R-HSA-392518 | 9.90965664735e-06 | 0.6 | GNG7 GNG5 GNAI3 | Signal amplification |
| REAC:R-HSA-977444 | 1.34474619847e-05 | 0.6 | GNG7 GNG5 GNAI3 | GABA B receptor activation |
| REAC:R-HSA-991365 | 1.34474619847e-05 | 0.6 | GNG7 GNG5 GNAI3 | Activation of GABAB receptors |
| REAC:R-HSA-6814122 | 2.47599987196e-05 | 0.6 | GNG7 GNG5 GNAI3 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-418597 | 3.58634423945e-05 | 0.6 | GNG7 GNG5 GNAI3 | G alpha (z) signalling events |
| REAC:R-HSA-977443 | 4.10976418258e-05 | 0.6 | GNG7 GNG5 GNAI3 | GABA receptor activation |
| KEGG:04727 | 6.78759182453e-05 | 0.6 | GNG7 GNG5 GNAI3 | GABAergic synapse |
| WP:WP35 | 7.07040269841e-05 | 0.6 | GNG7 GNG5 GNAI3 | G Protein Signaling Pathways |
| KEGG:05032 | 7.32179527008e-05 | 0.6 | GNG7 GNG5 GNAI3 | Morphine addiction |
| KEGG:04713 | 9.41040777628e-05 | 0.6 | GNG7 GNG5 GNAI3 | Circadian entrainment |
| KEGG:04726 | 0.000118613727961 | 0.6 | GNG7 GNG5 GNAI3 | Serotonergic synapse |
| KEGG:04725 | 0.000122427590077 | 0.6 | GNG7 GNG5 GNAI3 | Cholinergic synapse |
| REAC:R-HSA-9009391 | 0.000123638575202 | 0.6 | GNG7 GNG5 GNAI3 | Extra-nuclear estrogen signaling |
| KEGG:04724 | 0.000138497553003 | 0.6 | GNG7 GNG5 GNAI3 | Glutamatergic synapse |
| WP:WP536 | 0.000186709829938 | 0.6 | GNG7 GNG5 GNAI3 | Calcium Regulation in the Cardiac Cell |
| WP:WP3929 | 0.000206095076976 | 0.6 | GNG7 GNG5 GNAI3 | Chemokine signaling pathway |
| KEGG:04926 | 0.000240055495634 | 0.6 | GNG7 GNG5 GNAI3 | Relaxin signaling pathway |
| KEGG:04728 | 0.000246133668344 | 0.6 | GNG7 GNG5 GNAI3 | Dopaminergic synapse |
| KEGG:04371 | 0.000264979384683 | 0.6 | GNG7 GNG5 GNAI3 | Apelin signaling pathway |
| REAC:R-HSA-111885 | 0.000275953181812 | 0.6 | GNG7 GNG5 GNAI3 | Opioid Signalling |
| KEGG:04062 | 0.000305495250573 | 0.6 | GNG7 GNG5 GNAI3 | Chemokine signaling pathway |
| REAC:R-HSA-390466 | 0.000316649083447 | 0.6 | GNG7 GNG5 GNAI3 | Chaperonin-mediated protein folding |
| KEGG:04723 | 0.000319861510109 | 0.6 | GNG7 GNG5 GNAI3 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-391251 | 0.000384877154433 | 0.6 | GNG7 GNG5 GNAI3 | Protein folding |
| KEGG:05034 | 0.000636959120994 | 0.6 | GNG7 GNG5 GNAI3 | Alcoholism |
| KEGG:05170 | 0.00109699385517 | 0.6 | GNG7 GNG5 GNAI3 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.00114726739179 | 0.6 | GNG7 GNG5 GNAI3 | Human cytomegalovirus infection |
| REAC:R-HSA-8964315 | 0.00161668141155 | 0.4 | GNG5 GNG7 | G beta:gamma signalling through BTK |
| REAC:R-HSA-392851 | 0.00183199274719 | 0.4 | GNG5 GNG7 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-997272 | 0.00206071490935 | 0.4 | GNG5 GNG7 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-1296041 | 0.00206071490935 | 0.4 | GNG5 GNG7 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-1296059 | 0.00206071490935 | 0.4 | GNG5 GNG7 | G protein gated Potassium channels |
| REAC:R-HSA-8964616 | 0.00206071490935 | 0.4 | GNG5 GNG7 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-418217 | 0.00206071490935 | 0.4 | GNG5 GNG7 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-500657 | 0.00230284247734 | 0.4 | GNG5 GNG7 | Presynaptic function of Kainate receptors |
| REAC:R-HSA-112314 | 0.00234614610155 | 0.6 | GNG7 GNG5 GNAI3 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0005834 | 0.00235581550516 | 0.6 | GNG7 GNG5 GNAI3 | heterotrimeric G-protein complex |
| GO:1905360 | 0.00235581550516 | 0.6 | GNG7 GNG5 GNAI3 | GTPase complex |
| REAC:R-HSA-418555 | 0.00238658832736 | 0.6 | GNG7 GNG5 GNAI3 | G alpha (s) signalling events |
| REAC:R-HSA-428930 | 0.00282729215335 | 0.4 | GNG5 GNG7 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-420092 | 0.00282729215335 | 0.4 | GNG5 GNG7 | Glucagon-type ligand receptors |
| REAC:R-HSA-392451 | 0.00282729215335 | 0.4 | GNG5 GNG7 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-418592 | 0.0031096034254 | 0.4 | GNG5 GNG7 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-1296065 | 0.00340529843133 | 0.4 | GNG5 GNG7 | Inwardly rectifying K+ channels |
| REAC:R-HSA-8939211 | 0.00371466203946 | 0.6 | GNG7 GNG5 GNAI3 | ESR-mediated signaling |
| REAC:R-HSA-400042 | 0.00437263170532 | 0.4 | GNG5 GNG7 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-451326 | 0.00472180750517 | 0.4 | GNG5 GNG7 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-76002 | 0.00484900153486 | 0.6 | GNG7 GNG5 GNAI3 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-397795 | 0.00508433997358 | 0.4 | GNG5 GNG7 | G-protein beta:gamma signalling |
| REAC:R-HSA-456926 | 0.00508433997358 | 0.4 | GNG5 GNG7 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-112315 | 0.005113781726 | 0.6 | GNG7 GNG5 GNAI3 | Transmission across Chemical Synapses |
| REAC:R-HSA-163359 | 0.00625202329777 | 0.4 | GNG5 GNG7 | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-9006931 | 0.00634577840696 | 0.6 | GNG7 GNG5 GNAI3 | Signaling by Nuclear Receptors |
| WP:WP2032 | 0.00688743357746 | 0.4 | RAP1GAP GNAI3 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| REAC:R-HSA-418594 | 0.00775951386318 | 0.6 | GNG7 GNG5 GNAI3 | G alpha (i) signalling events |
| REAC:R-HSA-381676 | 0.00799559968784 | 0.4 | GNG5 GNG7 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-432040 | 0.00894729002053 | 0.4 | GNG5 GNG7 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 0.00995219083388 | 0.4 | GNG5 GNG7 | Aquaporin-mediated transport |
| KEGG:05200 | 0.0137388951306 | 0.6 | GNG7 GNG5 GNAI3 | Pathways in cancer |
| REAC:R-HSA-112316 | 0.0172109299174 | 0.6 | GNG7 GNG5 GNAI3 | Neuronal System |
| REAC:R-HSA-4086398 | 0.0184727645209 | 0.4 | GNG5 GNG7 | Ca2+ pathway |
| REAC:R-HSA-373080 | 0.0253191001807 | 0.4 | GNG5 GNG7 | Class B/2 (Secretin family receptors) |
| WP:WP289 | 0.0279458043607 | 0.4 | GNG5 GNG7 | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-422356 | 0.0313816354582 | 0.4 | GNG5 GNG7 | Regulation of insulin secretion |
| REAC:R-HSA-1296071 | 0.0351349281697 | 0.4 | GNG5 GNG7 | Potassium Channels |
| REAC:R-HSA-416482 | 0.0351349281697 | 0.4 | GNG5 GNG7 | G alpha (12/13) signalling events |
| WP:WP4223 | 0.0390434201563 | 0.4 | GNG5 GNG7 | Ras Signaling |
| REAC:R-HSA-418346 | 0.0390979640759 | 0.4 | GNG5 GNG7 | Platelet homeostasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAI3 | GNG5 | 0.746 | 0.741 | bioplex (GNAI3) bioplex_WMM |
| GNAI3 | ANKRD13B | 0.231 | 0.469 | bioplex (GNAI3) bioplex_WMM |
| GNAI3 | RAP1GAP | 0.097 | 0.359 | bioplex (GNAI3) bioplex_WMM |
| GNAI3 | GNG7 | 0.042 | 0.27 | bioplex (GNAI3) bioplex_WMM |
| GNG5 | GNG7 | 0.017 | 0.175 | bioplex_WMM WMM_only |
| RAP1GAP | ANKRD13B | 0.01 | 0.105 | bioplex_WMM WMM_only |
| RAP1GAP | GNG7 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| ANKRD13B | GNG7 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| GNG5 | RAP1GAP | 0.008 | 0.06 | bioplex_WMM WMM_only |
| GNG5 | ANKRD13B | 0.008 | 0.06 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04026 has an average edge precision of 0.24 which is ranked 5519 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAP1GAP | HuMAP2_04026 HuMAP2_05902 |
| GNG5 | HuMAP2_02804 HuMAP2_04026 HuMAP2_04804 HuMAP2_05902 |
| GNG7 | HuMAP2_04026 HuMAP2_05902 |
| ANKRD13B | HuMAP2_04026 HuMAP2_05902 |
| GNAI3 | HuMAP2_01804 HuMAP2_02804 HuMAP2_03884 HuMAP2_04026 HuMAP2_04804 HuMAP2_05902 |